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UniProtKB/Swiss-Prot entry P07311


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ACYP1_HUMAN
Primary accession number P07311
Secondary accession numbers None
Integrated into Swiss-Prot on April 1, 1988
Sequence was last modified on January 23, 2007 (Sequence version 2)
Annotations were last modified on    November 4, 2008 (Entry version 81)
Name and origin of the protein
Protein name Acylphosphatase-1
Synonyms EC 3.6.1.7
Acylphosphate phosphohydrolase 1
Acylphosphatase, organ-common type isozyme
Acylphosphatase, erythrocyte isozyme
Gene name
Name: ACYP1
Synonyms: ACYPE
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Placenta;
Raugei G.;
Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature01348; PubMed=12508121 [NCBI, ExPASy, EBI, Israel, Japan]
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.;
"The DNA sequence and analysis of human chromosome 14.";
Nature 421:601-607(2003).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Mammary gland;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
PROTEIN SEQUENCE OF 2-99.
DOI=10.1021/bi00372a044; PubMed=3026468 [NCBI, ExPASy, EBI, Israel, Japan]
Liguri G., Camici G., Manao G., Cappugi G., Nassi P., Modesti A., Ramponi G.;
"A new acylphosphatase isoenzyme from human erythrocytes: purification, characterization, and primary structure.";
Biochemistry 25:8089-8094(1986).
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 10-86.
TISSUE=Placenta;
DOI=10.1016/0014-5793(95)00553-L; PubMed=7796909 [NCBI, ExPASy, EBI, Israel, Japan]
Fiaschi T., Raugei G., Marzocchini R., Chiarugi P., Cirri P., Ramponi G.;
"Cloning and expression of the cDNA coding for the erythrocyte isoenzyme of human acylphosphatase.";
FEBS Lett. 367:145-148(1995).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X84194; CAA58987.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC007055; AAD31937.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC035568; AAH35568.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S66187; QPHUE.
RefSeq NP_001098.1; -.
NP_982355.1; -.
UniGene Hs.18573
3D structure databases
HSSP P41500; 2ACY. [HSSP ENTRY / PDB]
SMR P07311; 2-99.
ModBase P07311.
Organism-specific databases
H-InvDB HIX0026751; -.
HIX0074267; -.
HGNC HGNC:179; ACYP1.
GenAtlas ACYP1.
MIM 600875; gene. [NCBI / EBI]
PharmGKB PA24499; -.
GeneCards P07311.
Gene expression databases
ArrayExpress P07311; -.
CleanEx HS_ACYP1; -.
GermOnline ENSG00000119640; Homo sapiens.
Ontologies
GO
GO:0003998; Molecular function: acylphosphatase activity (traceable author statement from ProtInc).
GO:0006796; Biological process: phosphate metabolic process (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR001792; Acylphosphatase.
Graphical view of domain structure.
PANTHER PTHR10029; Acylphosphatase; 1.
Pfam PF00708; Acylphosphatase; 1.
Pfam graphical view of domain structure.
PRINTS PR00112; ACYLPHPHTASE.
ProDom PD001884; Acylphosphatase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00150; ACYLPHOSPHATASE_1; 1.
PS00151; ACYLPHOSPHATASE_2; 1.
PS51160; ACYLPHOSPHATASE_3; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P07311.
ProtoNet P07311.
Genome annotation databases
Ensembl ENSG00000119640; Homo sapiens. [Contig view]
GeneID 97; -.
KEGG hsa:97; -.
Phylogenomic databases
HOGENOM P07311; -.
HOVERGEN P07311; -.
Other
NextBio 367; -.
SOURCE ACYP1; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Direct protein sequencing; Hydrolase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom  To Length Description FTId
INIT_MET   1    1        Removed. 
CHAIN   2   99  98     Acylphosphatase-1. PRO_0000158535
DOMAIN   9   99  91     Acylphosphatase-like. 
ACT_SITE   24   24        Potential. 
ACT_SITE   42   42        Potential. 
MOD_RES   2    2        N-acetylalanine. 
CONFLICT   20   20        G -> R (in Ref. 5). 
Sequence information
Length: 99 AA [This is the length of the unprocessed precursor] Molecular weight: 11261 Da [This is the MW of the unprocessed precursor] CRC64: F9F787E490BC8296 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAEGNTLISV DYEIFGKVQG VFFRKHTQAE GKKLGLVGWV QNTDRGTVQG QLQGPISKVR 

        70         80         90 
HMQEWLETRG SPKSHIDKAN FNNEKVILKL DYSDFQIVK 

P07311 in FASTA format

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