ID   KCRM_MOUSE              Reviewed;         381 AA.
AC   P07310;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   04-NOV-2008, entry version 69.
DE   RecName: Full=Creatine kinase M-type;
DE            EC=2.7.3.2;
DE   AltName: Full=Creatine kinase M chain;
DE   AltName: Full=M-CK;
GN   Name=Ckm; Synonyms=Ckmm;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=86115302; PubMed=3003372; DOI=10.1007/BF02115689;
RA   Buskin J.N., Jaynes J.B., Chamberlain J.S., Hauschka S.D.;
RT   "The mouse muscle creatine kinase cDNA and deduced amino acid
RT   sequences: comparison to evolutionarily related enzymes.";
RL   J. Mol. Evol. 22:334-341(1985).
CC   -!- FUNCTION: Reversibly catalyzes the transfer of phosphate between
CC       ATP and various phosphogens (e.g. creatine phosphate). Creatine
CC       kinase isoenzymes play a central role in energy transduction in
CC       tissues with large, fluctuating energy demands, such as skeletal
CC       muscle, heart, brain and spermatozoa.
CC   -!- CATALYTIC ACTIVITY: ATP + creatine = ADP + phosphocreatine.
CC   -!- SUBUNIT: Dimer of identical or non-identical chains. With MM being
CC       the major form in skeletal muscle and myocardium, MB existing in
CC       myocardium, and BB existing in many tissues, especially brain.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the ATP:guanido phosphotransferase family.
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DR   EMBL; X03233; CAA26979.1; -; mRNA.
DR   PIR; A23590; A23590.
DR   RefSeq; NP_031736.1; -.
DR   UniGene; Mm.2375; -.
DR   HSSP; P00563; 2CRK.
DR   SMR; P07310; 2-381.
DR   PhosphoSite; P07310; -.
DR   SWISS-2DPAGE; P07310; -.
DR   Ensembl; ENSMUSG00000030399; Mus musculus.
DR   GeneID; 12715; -.
DR   KEGG; mmu:12715; -.
DR   MGI; MGI:88413; Ckm.
DR   HOGENOM; P07310; -.
DR   HOVERGEN; P07310; -.
DR   NextBio; 281984; -.
DR   ArrayExpress; P07310; -.
DR   CleanEx; MM_CKM; -.
DR   GermOnline; ENSMUSG00000030399; Mus musculus.
DR   GO; GO:0004111; F:creatine kinase activity; IDA:MGI.
DR   GO; GO:0046314; P:phosphocreatine biosynthetic process; IDA:MGI.
DR   InterPro; IPR000749; ATP-gua_Ptrans.
DR   InterPro; IPR014746; Gln_synth/guanido_kin_cat.
DR   Gene3D; G3DSA:1.10.135.10; ATP-gua_Ptrans; 1.
DR   Gene3D; G3DSA:3.30.590.10; ATP-gua_Ptrans; 1.
DR   PANTHER; PTHR11547; ATP-gua_Ptrans; 1.
DR   Pfam; PF00217; ATP-gua_Ptrans; 1.
DR   Pfam; PF02807; ATP-gua_PtransN; 1.
DR   PROSITE; PS00112; GUANIDO_KINASE; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Cytoplasm; Kinase; Nucleotide-binding; Transferase.
FT   CHAIN         1    381       Creatine kinase M-type.
FT                                /FTId=PRO_0000211976.
FT   NP_BIND     128    132       ATP (By similarity).
FT   NP_BIND     320    325       ATP (By similarity).
FT   BINDING     191    191       ATP (By similarity).
FT   BINDING     236    236       ATP (By similarity).
FT   BINDING     292    292       ATP (By similarity).
FT   BINDING     335    335       ATP (By similarity).
SQ   SEQUENCE   381 AA;  43045 MW;  B573FEB1D2A41056 CRC64;
     MPFGNTHNKF KLNYKPQEEY PDLSKHNNHM AKVLTPDLYN KLRDKETPSG FTLDDVIQTG
     VDNPGHPFIM TVGCVAGDEE SYTVFKDLFD PIIQDRHGGY KPTDKHKTDL NHENLKGGDD
     LDPNYVLSSR VRTGRSIKGY TLPPHCSRGE RRAVEKLSVE ALNSLTGEFK GKYYPLKSMT
     EQEQQQLIDD HFLFDKPVSP LLLASGMARD WPDARGIWHN DNKSFLVWVN EEDHLRVISM
     EKGGNMKEVF RRFCVGLQKI EEIFKKAGHP FMWNEHLGYV LTCPSNLGTG LRGGVHVKLA
     NLSKHPKFEE ILTRLRLQKR GTGGVDTAAV GAVFDISNAD RLGSSEVEQV QLVVDGVKLM
     VEMEKKLEKG QSIDDMIPAQ K
//