ID   FABPL_HUMAN             Reviewed;         127 AA.
AC   P07148;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   04-NOV-2008, entry version 89.
DE   RecName: Full=Fatty acid-binding protein, liver;
DE   AltName: Full=L-FABP;
GN   Name=FABP1; Synonyms=FABPL;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=85131017; PubMed=3838309;
RA   Chan L., Wei C.-F., Li W.-H., Yang C.-Y., Ratner P., Pownall H.,
RA   Gotto A.M. Jr., Smith L.C.;
RT   "Human liver fatty acid binding protein cDNA and amino acid sequence.
RT   Functional and evolutionary implications.";
RL   J. Biol. Chem. 260:2629-2632(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ALA-94.
RX   MEDLINE=85131136; PubMed=3838313;
RA   Lowe J.B., Boguski M.S., Sweetser D.A., Elshourbagy N.A., Taylor J.M.,
RA   Gordon J.I.;
RT   "Human liver fatty acid binding protein. Isolation of a full length
RT   cDNA and comparative sequence analyses of orthologous and paralogous
RT   proteins.";
RL   J. Biol. Chem. 260:3413-3417(1985).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Colon, Kidney, and Stomach;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   STRUCTURE BY NMR.
RX   PubMed=17536800; DOI=10.1021/ja071442e;
RA   Xu Y., Long D., Yang D.;
RT   "Rapid data collection for protein structure determination by NMR
RT   spectroscopy.";
RL   J. Am. Chem. Soc. 129:7722-7723(2007).
RN   [5]
RP   X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
RG   Structural genomics consortium (SGC);
RT   "Crystal structure of human FABP1.";
RL   Submitted (DEC-2005) to the PDB data bank.
CC   -!- FUNCTION: Binds free fatty acids and their coenzyme A derivatives,
CC       bilirubin, and some other small molecules in the cytoplasm. May be
CC       involved in intracellular lipid transport.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- DOMAIN: Forms a beta-barrel structure that accommodates
CC       hydrophobic ligands in its interior.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Fatty-acid binding
CC       protein (FABP) family.
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DR   EMBL; M10617; AAA52419.1; -; mRNA.
DR   EMBL; M10050; AAA52418.1; -; mRNA.
DR   EMBL; BC032801; AAH32801.1; -; mRNA.
DR   PIR; A22289; FZHUL.
DR   RefSeq; NP_001434.1; -.
DR   UniGene; Hs.380135; -.
DR   PDB; 2F73; X-ray; 2.50 A; A/B/C/D/E/F/G/H=1-127.
DR   PDB; 2PY1; NMR; -; A=1-127.
DR   PDBsum; 2F73; -.
DR   PDBsum; 2PY1; -.
DR   PhosphoSite; P07148; -.
DR   SWISS-2DPAGE; P07148; -.
DR   PMMA-2DPAGE; P07148; -.
DR   Siena-2DPAGE; P07148; -.
DR   Ensembl; ENSG00000163586; Homo sapiens.
DR   GeneID; 2168; -.
DR   KEGG; hsa:2168; -.
DR   H-InvDB; HIX0002246; -.
DR   HGNC; HGNC:3555; FABP1.
DR   HPA; CAB002305; -.
DR   MIM; 134650; gene.
DR   PharmGKB; PA27956; -.
DR   HOGENOM; P07148; -.
DR   HOVERGEN; P07148; -.
DR   NextBio; 8755; -.
DR   ArrayExpress; P07148; -.
DR   CleanEx; HS_FABP1; -.
DR   GermOnline; ENSG00000163586; Homo sapiens.
DR   GO; GO:0009887; P:organ morphogenesis; TAS:ProtInc.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR000463; Fatty_acid_bd.
DR   InterPro; IPR000566; Lipocln_cytFABP.
DR   Gene3D; G3DSA:2.40.128.20; Calycin; 1.
DR   PANTHER; PTHR11955; Fatty_acid_bd; 1.
DR   Pfam; PF00061; Lipocalin; 1.
DR   PRINTS; PR00178; FATTYACIDBP.
DR   PROSITE; PS00214; FABP; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Acetylation; Cytoplasm; Lipid-binding; Phosphoprotein;
KW   Polymorphism; Transport.
FT   CHAIN         1    127       Fatty acid-binding protein, liver.
FT                                /FTId=PRO_0000067334.
FT   MOD_RES       1      1       N-acetylmethionine.
FT   MOD_RES      56     56       Phosphoserine (By similarity).
FT   VARIANT      54     54       A -> T (in dbSNP:rs1801273).
FT                                /FTId=VAR_014662.
FT   VARIANT      94     94       T -> A (in dbSNP:rs2241883).
FT                                /FTId=VAR_022093.
FT   STRAND        5     13
FT   HELIX        15     21
FT   HELIX        26     32
FT   STRAND       38     44
FT   STRAND       47     54
FT   STRAND       57     64
FT   STRAND       67     72
FT   STRAND       74     76
FT   STRAND       78     82
FT   STRAND       84     86
FT   TURN         87     89
FT   STRAND       90     95
FT   STRAND       98    105
FT   STRAND      108    115
SQ   SEQUENCE   127 AA;  14208 MW;  065DCEFB08DAB6B6 CRC64;
     MSFSGKYQLQ SQENFEAFMK AIGLPEELIQ KGKDIKGVSE IVQNGKHFKF TITAGSKVIQ
     NEFTVGEECE LETMTGEKVK TVVQLEGDNK LVTTFKNIKS VTELNGDIIT NTMTLGDIVF
     KRISKRI
//