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UniProtKB/Swiss-Prot entry P07023


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name TYRA_ECOLI
Primary accession number P07023
Secondary accession numbers P78205 P78206
Integrated into Swiss-Prot on April 1, 1988
Sequence was last modified on April 1, 1988 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 88)
Name and origin of the protein
Protein name T-protein
Synonyms None
Includes Chorismate mutase
     (CM)
     (EC 5.4.99.5)
Prephenate dehydrogenase
     (PDH)
     (EC 1.3.1.12)
Gene name
Name: tyrA
OrderedLocusNames: b2600, JW2581
From
Escherichia coli (strain K12) [TaxID: 83333] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=K12;
DOI=10.1016/0022-2836(84)90269-9; PubMed=6396419 [NCBI, ExPASy, EBI, Israel, Japan]
Hudson G.S., Davidson B.E.;
"Nucleotide sequence and transcription of the phenylalanine and tyrosine operons of Escherichia coli K12.";
J. Mol. Biol. 180:1023-1051(1984).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
DOI=10.1093/dnares/4.2.91; PubMed=9205837 [NCBI, ExPASy, EBI, Israel, Japan]
Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T., Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.;
"Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features.";
DNA Res. 4:91-113(1997).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / MG1655 / ATCC 47076;
DOI=10.1126/science.277.5331.1453; PubMed=9278503 [NCBI, ExPASy, EBI, Israel, Japan]
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.;
"The complete genome sequence of Escherichia coli K-12.";
Science 277:1453-1474(1997).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
DOI=10.1038/msb4100049; PubMed=16738553 [NCBI, ExPASy, EBI, Israel, Japan]
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.";
Mol. Syst. Biol. 2:E1-E5(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M10431; AAA24331.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U00096; AAC75649.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AP009048; BAA16485.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A30274; KMECTD.
RefSeq AP_003181.1; -.
NP_417091.1; -.
3D structure databases
ModBase P07023.
Protein-protein interaction databases
DIP DIP:11059N; -.
Enzyme and pathway databases
BioCyc EcoCyc:CHORISMUTPREPHENDEHYDROG-MON; -.
MetaCyc:CHORISMUTPREPHENDEHYDROG-MON; -.
2D gel databases
ECO2DBASE F037.9; 6TH EDITION.
Organism-specific databases
EchoBASE EB1032; -.
EcoGene EG11039; tyrA.
Ontologies
GO
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR008244; Chor_mut/prephenate_DHase_T.
IPR002701; Chorismate_mut.
IPR011277; CM_T.
IPR003099; Prephen_DHase.
Graphical view of domain structure.
PANTHER PTHR21363; Prephen_DH; 1.
Pfam PF01817; CM_2; 1.
PF02153; PDH; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF001499; Chor_mut_pdh_Tpr; 1.
TIGRFAMs TIGR01799; CM_T; 1.
PROSITE PS51168; CHORISMATE_MUT_2; 1.
PS51176; PDH_ADH; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P07023.
ProtoNet P07023.
Genome annotation databases
GeneID 947115; -.
GenomeReviews U00096_GR; b2600.
AP009048_GR; JW2581.
KEGG ecj:JW2581; -.
eco:b2600; -.
Phylogenomic databases
HOGENOM P07023; -.
Other
LinkHub P07023; -.
Genome annotation databases
CMR P07023; b2600.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Complete proteome; Cytoplasm; Isomerase; Multifunctional enzyme; NAD; Oxidoreductase; Tyrosine biosynthesis.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom  To Length Description FTId
CHAIN   1   373  373     T-protein. PRO_0000119195
DOMAIN   1    90  90     Chorismate mutase. 
DOMAIN   99   361  263     Prephenate/arogenate dehydrogenase. 
Sequence information
Length: 373 AA [This is the length of the unprocessed precursor] Molecular weight: 42043 Da [This is the MW of the unprocessed precursor] CRC64: 481D0A03DE2AC832 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MVAELTALRD QIDEVDKALL NLLAKRLELV AEVGEVKSRF GLPIYVPERE ASMLASRRAE 

        70         80         90        100        110        120 
AEALGVPPDL IEDVLRRVMR ESYSSENDKG FKTLCPSLRP VVIVGGGGQM GRLFEKMLTL 

       130        140        150        160        170        180 
SGYQVRILEQ HDWDRAADIV ADAGMVIVSV PIHVTEQVIG KLPPLPKDCI LVDLASVKNG 

       190        200        210        220        230        240 
PLQAMLVAHD GPVLGLHPMF GPDSGSLAKQ VVVWCDGRKP EAYQWFLEQI QVWGARLHRI 

       250        260        270        280        290        300 
SAVEHDQNMA FIQALRHFAT FAYGLHLAEE NVQLEQLLAL SSPIYRLELA MVGRLFAQDP 

       310        320        330        340        350        360 
QLYADIIMSS ERNLALIKRY YKRFGEAIEL LEQGDKQAFI DSFRKVEHWF GDYAQRFQSE 

       370 
SRVLLRQAND NRQ 

P07023 in FASTA format

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