[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. PubMed=3102479 [NCBI, ExPASy, EBI, Israel, Japan] Lal A.A., de la Cruz V.F., Welsh J.A., Charoenvit Y., Maloy W.L., McCutchan T.F.; "Structure of the gene encoding the circumsporozoite protein of Plasmodium yoelii. A rodent model for examining antimalarial sporozoite vaccines."; J. Biol. Chem. 262:2937-2940(1987).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-140 AND 260-367. DOI=10.1016/0166-6851(88)90176-4; PubMed=3287156 [NCBI, ExPASy, EBI, Israel, Japan] de la Cruz V.F., Lal A.A., McCutchan T.F.; "Variation among circumsporozoite protein genes from rodent malarias."; Mol. Biochem. Parasitol. 28:31-38(1988).

Comments

FUNCTION: The circumsporozoite protein is the immunodominant surface antigen on the sporozoite (the infective stage of the malaria parasite that is transmitted from the mosquito to the vertebrate host).
INTERACTION:
P52294:KPNA1 (xeno); NbExp=1; IntAct=EBI-1555692, EBI-358383;
O00505:KPNA3 (xeno); NbExp=1; IntAct=EBI-1555692, EBI-358297;
O00629:KPNA4 (xeno); NbExp=1; IntAct=EBI-1555692, EBI-396343;
O15131:KPNA5 (xeno); NbExp=1; IntAct=EBI-1555692, EBI-540602;
O60684:KPNA6 (xeno); NbExp=1; IntAct=EBI-1555692, EBI-359923;
DOMAIN: The C-terminal region is probably used for anchoring the protein to the cell membrane. The repeat sequences would be the surface antigen of the organism.
SIMILARITY: Belongs to the plasmodium circumsporozoite protein family.
SIMILARITY: Contains 1 TSP type-1 domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

J02695; AAA29558.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M18821; AAA29559.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M22698; AAA29560.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

ModBase

P06914.

Protein-protein interaction databases

IntAct

P06914; -.

Ontologies

GO:0005515;	Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.

Family and domain databases

InterPro

IPR003067; Crcmsprzoite.
IPR000884; TSP1.
Graphical view of domain structure.

Pfam

PF00090; TSP_1; 1.
Pfam graphical view of domain structure.

PRINTS

PR01303; CRCMSPRZOITE.

SMART

SM00209; TSP1; 1.
SMART graphical view of domain structure.

PROSITE

PS50092; TSP1; 1.
PROSITE graphical view of domain structure (profiles).

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Malaria; Repeat; Signal; Sporozoite.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 19`	`19`
`CHAIN`	`20 367`	`348`	`Circumsporozoite protein.`	`PRO_0000024536`
`REPEAT`	`139 144`	`6`	`1-1.`
`REPEAT`	`145 150`	`6`	`1-2.`
`REPEAT`	`151 156`	`6`	`1-3.`
`REPEAT`	`157 162`	`6`	`1-4.`
`REPEAT`	`163 168`	`6`	`1-5.`
`REPEAT`	`169 174`	`6`	`1-6.`
`REPEAT`	`175 180`	`6`	`1-7.`
`REPEAT`	`181 186`	`6`	`1-8.`
`REPEAT`	`187 192`	`6`	`1-9.`
`REPEAT`	`193 198`	`6`	`1-10.`
`REPEAT`	`199 204`	`6`	`1-11.`
`REPEAT`	`205 210`	`6`	`1-12.`
`REPEAT`	`211 216`	`6`	`1-13.`
`REPEAT`	`217 222`	`6`	`1-14.`
`REPEAT`	`223 228`	`6`	`1-15.`
`REPEAT`	`229 232`	`4`	`2-1; approximate.`
`REPEAT`	`233 236`	`4`	`2-2.`
`REPEAT`	`237 240`	`4`	`2-3.`
`REPEAT`	`241 244`	`4`	`2-4.`
`REPEAT`	`245 248`	`4`	`2-5.`
`REPEAT`	`249 252`	`4`	`2-6.`
`REPEAT`	`253 256`	`4`	`2-7.`
`REPEAT`	`257 260`	`4`	`2-8; approximate.`
`DOMAIN`	`294 345`	`52`	`TSP type-1.`
`REGION`	`139 228`	`90`	`15 X 6 AA tandem repeats of Q-G-P-G-A-P.`
`REGION`	`229 260`	`32`	`8 X 4 AA approximate tandem repeats of Q-Q-P-P.`

Sequence information

Length: 367 AA [This is the length of the unprocessed precursor]

Molecular weight: 38888 Da [This is the MW of the unprocessed precursor]

CRC64: 1EA56AFF7FFCB5E3 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKKCTILVVA SLLLVDSLLP GYGQNKSVQA QRNLNELCYN EENDNKLYHV LNSKNGKIYN 

        70         80         90        100        110        120 
RNIVNRLLGD ALNGKPEEKK DDPPKDGNKD DLPKEEKKDD LPKEEKKDDP PKDPKKDDPP 

       130        140        150        160        170        180 
KEAQNKLNQP VVADENVDQG PGAPQGPGAP QGPGAPQGPG APQGPGAPQG PGAPQGPGAP 

       190        200        210        220        230        240 
QGPGAPQGPG APQGPGAPQG PGAPQGPGAP QGPGAPQGPG APQGPGAPQE PPQQPPQQPP 

       250        260        270        280        290        300 
QQPPQQPPQQ PPQQPPQQPR PQPDGNNNNN NNNGNNNEDS YVPSAEQILE FVKQISSQLT 

       310        320        330        340        350        360 
EEWSQCSVTC GSGVRVRKRK NVNKQPENLT LEDIDTEICK MDKCSSIFNI VSNSLGFVIL 


LVLVFFN

P06914 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools