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UniProtKB/Swiss-Prot entry P06623

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CN37_BOVIN
Primary accession number P06623
Secondary accession number Q3SZJ6
Integrated into Swiss-Prot on January 1, 1988
Sequence was last modified on July 1, 1993 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 63)
Name and origin of the protein
Protein name 2',3'-cyclic-nucleotide 3'-phosphodiesterase
Synonyms CNPase
CNP
EC 3.1.4.37
Gene name
Name: CNP
From
Bos taurus (Bovine) [TaxID: 9913] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
PubMed=3029107 [NCBI, ExPASy, EBI, Israel, Japan]
Kurihara T., Fowler A.V., Takahashi Y.;
"cDNA cloning and amino acid sequence of bovine brain 2',3'-cyclic-nucleotide 3'-phosphodiesterase.";
J. Biol. Chem. 262:3256-3261(1987).
[2]
 ERRATUM, AND SEQUENCE REVISION TO 318.
Kurihara T., Fowler A.V., Takahashi Y.;
J. Biol. Chem. 262:16754-16754(1987).
[3]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Retina;
DOI=10.1093/nar/15.17.7204; PubMed=2821502 [NCBI, ExPASy, EBI, Israel, Japan]
Vogel U.S., Thompson R.J.;
"Nucleotide sequence of bovine retina 2',3'-cyclic nucleotide 3'-phosphohydrolase.";
Nucleic Acids Res. 15:7204-7204(1987).
[4]
 NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/0014-5793(87)81058-X; PubMed=3036592 [NCBI, ExPASy, EBI, Israel, Japan]
Vogel U.S., Thompson R.J.;
"Molecular cloning of the myelin specific enzyme 2',3'-cyclic-nucleotide 3'-phosphohydrolase.";
FEBS Lett. 218:261-265(1987).
[5]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Crossbred X Angus;
TISSUE=Ileum;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
J02659; AAA30456.1; ALT_SEQ; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Y00405; CAA68466.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M27606; AAA30457.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC102820; AAI02821.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A26861; ESBOP3.
RefSeq NP_851336.1; -.
UniGene Bt.5517
3D structure databases
SMR P06623; 165-378.
ModBase P06623.
Protein-protein interaction databases
IntAct P06623; -.
Ontologies
GO
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.
Family and domain databases
InterPro IPR008431; CNPase.
Graphical view of domain structure.
PANTHER PTHR10156; CNPase; 1.
Pfam PF05881; CNPase; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000970; CNPase; 1.
BLOCKS P06623.
ProtoNet P06623.
Genome annotation databases
Ensembl ENSBTAG00000025762; Bos taurus. [Contig view]
GeneID 280752; -.
KEGG bta:280752; -.
Phylogenomic databases
HOVERGEN P06623; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Hydrolase; Membrane; Phosphoprotein.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   400  400     2',3'-cyclic-nucleotide 3'-phosphodiesterase. PRO_0000089960
ACT_SITE   230   230        By similarity. 
ACT_SITE   309   309        By similarity. 
MOD_RES   352   352        Phosphotyrosine (By similarity). 
Sequence information
Length: 400 AA [This is the length of the unprocessed precursor] Molecular weight: 44875 Da [This is the MW of the unprocessed precursor] CRC64: 3448FC367D647CF8 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSSSGAKDKP ELQFPFLQDE ETVATLQECK TLFILRGLPG SGKSTLARFI VDKYRDGTKM 

        70         80         90        100        110        120 
VSADSYKITP GARGSFSEEY KQLDEDLAAC CRRDFRVLVL DDTNHERERL EQLFELADQY 

       130        140        150        160        170        180 
QYQVVLVEPK TAWRLDCAQL KEKNQWQLSA DDLKKLKPGL EKDFLPLYFG WFLTKKSSAA 

       190        200        210        220        230        240 
LWKTGQTFLE ELGNHKAFKK ELRHFVSGDE PREKIELVTY FGKRPPGVLH CTTKFCDYGK 

       250        260        270        280        290        300 
AAGAEEYAQQ DVVKKSYCKA FTLTISALFV TPKTTGARVE LSEQQLALWP NDVDKLSPSD 

       310        320        330        340        350        360 
NLPRGSRAHI TLGCAGDVEA VQTGIDLLEI VRQEKGGSRG EEVGELSRGK LYSLGSGRWM 

       370        380        390        400 
LSLAKKMEVR AIFTGYYGKG KAVPIRSGRK GGSFQSCTII
P06623 in FASTA format

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