[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. PubMed=3025178 [NCBI, ExPASy, EBI, Israel, Japan] Monod M., Mohan S., Dubnau D.; "Cloning and analysis of ermG, a new macrolide-lincosamide-streptogramin B resistance element from Bacillus sphaericus."; J. Bacteriol. 169:340-350(1987).

Comments

FUNCTION: This protein produces a dimethylation of the adenine residue at position 2058 in 23S rRNA, resulting in reduced affinity between ribosomes and macrolide-lincosamide-streptogramin B antibiotics.
CATALYTIC ACTIVITY: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N⁶-methyladenine.
SIMILARITY: Belongs to the rRNA adenine N(6)-methyltransferase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M15332; AAA22419.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

C26930; C26930.

3D structure databases

HSSP

P13956; 1QAN. [HSSP ENTRY / PDB]

SMR

P06571; 9-243.

ModBase

P06571.

Ontologies

GO:0008988;	Molecular function: rRNA (adenine-N6-)-methyltransferase activity (inferred from electronic annotation from EC).
GO:0046677;	Biological process: response to antibiotic (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR001737; RRNA_meth_trans.
Graphical view of domain structure.

PANTHER

PTHR11727; RRNA_meth_trans; 1.

Pfam

PF00398; RrnaAD; 1.
Pfam graphical view of domain structure.

SMART

SM00650; rADc; 1.
SMART graphical view of domain structure.

PROSITE

PS01131; RRNA_A_DIMETH; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Antibiotic resistance; Methyltransferase; S-adenosyl-L-methionine; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 244`	`244`		`rRNA adenine N-6-methyltransferase.`	`PRO_0000101673`

Sequence information

Length: 244 AA [This is the length of the unprocessed precursor]

Molecular weight: 28557 Da [This is the MW of the unprocessed precursor]

CRC64: E64A1714B32225EF [This is a checksum on the sequence]

        10         20         30         40         50         60 
MNKVNIKDSQ NFITSKYHIE KIMNCISLDE KDNIFEIGAG KGHFTAELVK RCNFVTAIEI 

        70         80         90        100        110        120 
DSKLCEVTRN KLLNYPNYQI VNDDILKFTF PSHNPYKIFG SIPYNISTNI IRKIVFESSA 

       130        140        150        160        170        180 
TISYLIVEYG FAKRLLDTNR SLALLLMAEV DISILAKIPR YYFHPKPKVD SALIVLKRKP 

       190        200        210        220        230        240 
AKMAFKERKK YETFVMKWVN KEYEKLFTKN QFNKALKHAR IYDINNISFE QFVSLFNSYK 


IFNG

P06571 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools