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UniProtKB/Swiss-Prot entry P06525


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ADH1_ARATH
Primary accession number P06525
Secondary accession numbers O04080 O04713 O04717 O04868 O23821 Q8LA61 Q94AY6 Q9CAZ2 Q9CAZ3
Integrated into Swiss-Prot on January 1, 1988
Sequence was last modified on May 29, 2007 (Sequence version 2)
Annotations were last modified on    November 4, 2008 (Entry version 82)
Name and origin of the protein
Protein name Alcohol dehydrogenase class-P
Synonym EC 1.1.1.1
Gene name
Name: ADH1
Synonyms: ADH
OrderedLocusNames: At1g77120
ORFNames: F22K20.19
From
Arabidopsis thaliana (Mouse-ear cress) [TaxID: 3702] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; rosids; eurosids II; Brassicales; Brassicaceae; Arabidopsis.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2937058 [NCBI, ExPASy, EBI, Israel, Japan]
Chang C., Meyerowitz E.M.;
"Molecular cloning and DNA sequence of the Arabidopsis thaliana alcohol dehydrogenase gene.";
Proc. Natl. Acad. Sci. U.S.A. 83:1408-1412(1986).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=7851777 [NCBI, ExPASy, EBI, Israel, Japan]
Hanfstingl U., Berry A., Kellogg E.A., Costa J.T. III, Ruediger W., Ausubel F.M.;
"Haplotypic divergence coupled with lack of diversity at the Arabidopsis thaliana alcohol dehydrogenase locus: roles for both balancing and directional selection?";
Genetics 138:811-828(1994).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=cv. Al-0, cv. Bl-1, cv. Bla-10, cv. Bs-0, cv. Chi-0, cv. Ci-0, cv. Es-0, cv. Gr-1, cv. Ita-0, and cv. Yo-0;
PubMed=8844162 [NCBI, ExPASy, EBI, Israel, Japan]
Innan H., Tajima F., Terauchi R., Miyashita N.T.;
"Intragenic recombination in the Adh locus of the wild plant Arabidopsis thaliana.";
Genetics 143:1761-1770(1996).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=cv. Aa-0, cv. Hiroshima, cv. Mt-0, cv. Pog-0, and cv. Shokei;
PubMed=8587508 [NCBI, ExPASy, EBI, Israel, Japan]
Miyashita N.T., Innan H., Terauchi R.;
"Intra- and interspecific variation of the alcohol dehydrogenase locus region in wild plants Arabis gemmifera and Arabidopsis thaliana.";
Mol. Biol. Evol. 13:433-436(1996).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=11018155 [NCBI, ExPASy, EBI, Israel, Japan]
Koch M.A., Haubold B., Mitchell-Olds T.;
"Comparative evolutionary analysis of chalcone synthase and alcohol dehydrogenase loci in Arabidopsis, Arabis, and related genera (Brassicaceae).";
Mol. Biol. Evol. 17:1483-1498(2000).
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=cv. Cvi-0, and cv. Kas-1;
PubMed=11158375 [NCBI, ExPASy, EBI, Israel, Japan]
Miyashita N.T.;
"DNA variation in the 5' upstream region of the Adh locus of the wild plants Arabidopsis thaliana and Arabis gemmifera.";
Mol. Biol. Evol. 18:164-171(2001).
[7]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=cv. C24;
Santos D.;
"Post-transcriptional silencing of the Arabidopsis adh1 gene triggered by a fully homologous transgene.";
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
DOI=10.1038/35048500; PubMed=11130712 [NCBI, ExPASy, EBI, Israel, Japan]
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.;
"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
Nature 408:816-820(2000).
[9]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
DOI=10.1126/science.1088305; PubMed=14593172 [NCBI, ExPASy, EBI, Israel, Japan]
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
"Empirical analysis of transcriptional activity in the Arabidopsis genome.";
Science 302:842-846(2003).
[10]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ASP-101 AND LYS-106.
Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.;
"Full-length cDNA from Arabidopsis thaliana.";
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
[11]
MUTANT R006.
DOI=10.1007/BF00271565; PubMed=2277648 [NCBI, ExPASy, EBI, Israel, Japan]
Dolferus R., van den Bossche D., Jacobs M.;
"Sequence analysis of two null-mutant alleles of the single Arabidopsis Adh locus.";
Mol. Gen. Genet. 224:297-302(1990).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M12196; AAA32728.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X77943; CAA54911.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D84240; BAA19615.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D84241; BAA19616.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D84242; BAA19617.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D84243; BAA19618.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D84244; BAA19619.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D84245; BAA19620.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D84246; BAA19621.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D84247; BAA19622.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D84248; BAA19623.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D84249; BAA19624.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D63460; BAA22983.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D63461; BAA22979.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D63462; BAA22980.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D63463; BAA22981.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D63464; BAA22982.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF110456; AAF23554.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB048394; BAB32568.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB048395; BAB32569.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY536888; AAS45601.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC002291; AAC00625.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY045612; AAK73970.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY090330; AAL90991.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY088010; AAM65556.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A23815; DEMUAM.
RefSeq NP_177837.1; -.
UniGene At.22653
3D structure databases
HSSP P11766; 1M6H. [HSSP ENTRY / PDB]
ModBase P06525.
Organism-specific databases
TAIR At1g77120; -.
Gene expression databases
ArrayExpress P06525; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0004022; Molecular function: alcohol dehydrogenase activity (inferred from electronic annotation from EC).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR013154; AlcDHase_GroES-like.
IPR002085; AlcDHase_SF_Zn.
IPR013149; AlcDHase_Zn-bd.
IPR002328; AlcDHase_Zn_CS.
Graphical view of domain structure.
PANTHER PTHR11695; ADH_Sf_Zn; 1.
Pfam PF08240; ADH_N; 1.
PF00107; ADH_zinc_N; 1.
Pfam graphical view of domain structure.
PROSITE PS00059; ADH_ZINC; 1.
BLOCKS P06525.
ProtoNet P06525.
Genome annotation databases
GeneID 844047; -.
GenomeReviews CT485782_GR; AT1G77120.
KEGG ath:AT1G77120; -.
NMPDR fig|3702.1.peg.7251; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   379  379     Alcohol dehydrogenase class-P. PRO_0000160697
METAL   47    47        Zinc 1; catalytic (By similarity). 
METAL   69    69        Zinc 1; catalytic (By similarity). 
METAL   99    99        Zinc 2 (By similarity). 
METAL   102   102        Zinc 2 (By similarity). 
METAL   105   105        Zinc 2 (By similarity). 
METAL   113   113        Zinc 2 (By similarity). 
METAL   177   177        Zinc 1; catalytic (By similarity). 
VARIANT   43    43  1     F -> Y (in strain: cv. Hiroshima). 
VARIANT   51    51  1     V -> L (in strain: cv. Bla-10, cv. Ci-0, cv. Cvi-0, cv. Hiroshima, cv. Kas-1 and cv. Ita-0). 
VARIANT   101   101  1     E -> D (in strain: cv. Aa-0, cv. Al-0, cv. Bl-1, cv. Bs-0, cv. Gr-1, cv. Mt-0, cv. Shokei and cv. Yo-0). 
VARIANT   106   106  1     H -> K (in strain: cv. Bl-1 and cv. Gr-1). 
VARIANT   106   106  1     H -> Q (in strain: cv. Aa-0, cv. Al-0, cv. Bs-0, cv. Mt-0, cv. Shokei and cv. Yo-0). 
VARIANT   120   120  1     T -> P (in strain: cv. Es-0). 
VARIANT   180   180  1     S -> A (in strain: cv. Bla-10). 
VARIANT   197   197  1     S -> T (in strain: cv. Cvi-0). 
VARIANT   217   217  1     A -> V (in strain: cv. Kas-1). 
MUTAGEN   105   105        C->Y: In R006; inactive enzyme. 
CONFLICT   154   154        V -> L (in Ref. 10; AAM65556). 
Sequence information
Length: 379 AA [This is the length of the unprocessed precursor] Molecular weight: 41178 Da [This is the MW of the unprocessed precursor] CRC64: 32550529538B9669 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSTTGQIIRC KAAVAWEAGK PLVIEEVEVA PPQKHEVRIK ILFTSLCHTD VYFWEAKGQT 

        70         80         90        100        110        120 
PLFPRIFGHE AGGIVESVGE GVTDLQPGDH VLPIFTGECG ECRHCHSEES NMCDLLRINT 

       130        140        150        160        170        180 
ERGGMIHDGE SRFSINGKPI YHFLGTSTFS EYTVVHSGQV AKINPDAPLD KVCIVSCGLS 

       190        200        210        220        230        240 
TGLGATLNVA KPKKGQSVAI FGLGAVGLGA AEGARIAGAS RIIGVDFNSK RFDQAKEFGV 

       250        260        270        280        290        300 
TECVNPKDHD KPIQQVIAEM TDGGVDRSVE CTGSVQAMIQ AFECVHDGWG VAVLVGVPSK 

       310        320        330        340        350        360 
DDAFKTHPMN FLNERTLKGT FFGNYKPKTD IPGVVEKYMN KELELEKFIT HTVPFSEINK 

       370 
AFDYMLKGES IRCIITMGA 

P06525 in FASTA format

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