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UniProtKB/Swiss-Prot entry P06307


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CCKN_HUMAN
Primary accession number P06307
Secondary accession numbers None
Integrated into Swiss-Prot on January 1, 1988
Sequence was last modified on January 1, 1988 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 84)
Name and origin of the protein
Protein name Cholecystokinin [Precursor]
Synonym CCK
Contains Cholecystokinin-58
     (CCK58)
Cholecystokinin-58 desnonopeptide
     ((1-49)-CCK58)
Cholecystokinin-39
     (CCK39)
Cholecystokinin-33
     (CCK33)
Cholecystokinin-25
     (CCK25)
Cholecystokinin-18
     (CCK18)
Cholecystokinin-12
     (CCK12)
Cholecystokinin-8
     (CCK8)
Cholecystokinin-7
     (CCK7)
Cholecystokinin-5
     (CCK5)
Gene name
Name: CCK
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=3856870 [NCBI, ExPASy, EBI, Israel, Japan]
Takahashi Y., Kato K., Hayashizaki Y., Wakabayashi T., Ohtsuka E., Matsuki S., Ikehara M., Matsubara K.;
"Molecular cloning of the human cholecystokinin gene by use of a synthetic probe containing deoxyinosine.";
Proc. Natl. Acad. Sci. U.S.A. 82:1931-1935(1985).
[2]
NUCLEOTIDE SEQUENCE.
Kato K., Takahashi Y., Matsubara K.;
"Molecular cloning of the human cholecystokinin gene.";
Ann. N. Y. Acad. Sci. 448:613-615(1985).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT GLU-32.
Livingston R.J., Rieder M.J., Chung M.-W., Ritchie T.K., Olson A.N., Nguyen C.P., Nguyen D.A., Poel C.L., Robertson P.D., Schackwitz W.S., Sherwood J.K., Sherwood A.M., Leithauser B.J., Nickerson D.A.;
"NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu).";
Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Pancreas;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
MUTAGENESIS OF TYR-97.
DOI=10.1021/bi0011072; PubMed=11076522 [NCBI, ExPASy, EBI, Israel, Japan]
Vishnuvardhan D., Beinfeld M.C.;
"Role of tyrosine sulfation and serine phosphorylation in the processing of procholecystokinin to amidated cholecystokinin and its secretion in transfected AtT-20 cells.";
Biochemistry 39:13825-13830(2000).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L00354; AAA53094.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BT006991; AAP35637.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY514491; AAR89908.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC008283; AAH08283.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A01623; GMHUCP.
RefSeq NP_000720.1; -.
UniGene Hs.458426
3D structure databases
ModBase P06307.
Polymorphism databases
NIEHS-SNPs CCK.
Organism-specific databases
H-InvDB HIX0003200; -.
HGNC HGNC:1569; CCK.
GenAtlas CCK.
HPA CAB002308; -.
MIM 118440; gene. [NCBI / EBI]
PharmGKB PA26141; -.
GeneCards P06307.
Gene expression databases
ArrayExpress P06307; -.
CleanEx HS_CCK; -.
GermOnline ENSG00000187094; Homo sapiens.
Ontologies
GO
GO:0005179; Molecular function: hormone activity (traceable author statement from ProtInc).
GO:0007165; Biological process: signal transduction (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR015499; CCK.
IPR001651; Gastrin.
IPR013152; Gastrin_CCK_CS.
Graphical view of domain structure.
PANTHER PTHR10786; CCK; 1.
Pfam PF00918; Gastrin; 1.
Pfam graphical view of domain structure.
SMART SM00029; GASTRIN; 1.
SMART graphical view of domain structure.
PROSITE PS00259; GASTRIN; 1.
BLOCKS P06307.
ProtoNet P06307.
Genome annotation databases
Ensembl ENSG00000187094; Homo sapiens. [Contig view]
GeneID 885; -.
KEGG hsa:885; -.
Phylogenomic databases
HOGENOM P06307; -.
HOVERGEN P06307; -.
Other
NextBio 3658; -.
SOURCE CCK; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amidation; Cleavage on pair of basic residues; Hormone; Polymorphism; Secreted; Signal; Sulfation.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    20  20      
CHAIN   21   115  95     Cholecystokinin. PRO_0000010536
PROPEP   21    44  24      PRO_0000010537
PEPTIDE   46   103  58     Cholecystokinin-58. PRO_0000010538
PEPTIDE   46    94  49     Cholecystokinin-58 desnonopeptide (By similarity). PRO_0000306304
PEPTIDE   65   103  39     Cholecystokinin-39. PRO_0000010539
PEPTIDE   71   103  33     Cholecystokinin-33. PRO_0000010540
PEPTIDE   79   103  25     Cholecystokinin-25 (By similarity). PRO_0000306305
PEPTIDE   86   103  18     Cholecystokinin-18 (By similarity). PRO_0000306306
PEPTIDE   92   103  12     Cholecystokinin-12. PRO_0000010541
PEPTIDE   96   103  8     Cholecystokinin-8. PRO_0000010542
PEPTIDE   97   103  7     Cholecystokinin-7 (By similarity). PRO_0000306307
PEPTIDE   99   103  5     Cholecystokinin-5 (By similarity). PRO_0000306308
PROPEP   107   115  9      PRO_0000010543
MOD_RES   97    97        Sulfotyrosine. 
MOD_RES   103   103        Phenylalanine amide. 
MOD_RES   111   111        Sulfotyrosine (By similarity). 
MOD_RES   113   113        Sulfotyrosine (By similarity). 
VARIANT   32    32  1     G -> E (in dbSNP:rs11571848 [NCBI]). VAR_018818 
VARIANT   95    95  1     R -> W (in dbSNP:rs3774395 [NCBI]). VAR_024452 
MUTAGEN   97    97        Y->F: Reduces the quantity of secreted CCK8 by 50%. 
Sequence information
Length: 115 AA [This is the length of the unprocessed precursor] Molecular weight: 12669 Da [This is the MW of the unprocessed precursor] CRC64: 8A3EE6442FAEAF4B [This is a checksum on the sequence]
        10         20         30         40         50         60 
MNSGVCLCVL MAVLAAGALT QPVPPADPAG SGLQRAEEAP RRQLRVSQRT DGESRAHLGA 

        70         80         90        100        110 
LLARYIQQAR KAPSGRMSIV KNLQNLDPSH RISDRDYMGW MDFGRRSAEE YEYPS 

P06307 in FASTA format

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