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UniProtKB/Swiss-Prot entry P06282


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CDH_ECOLI
Primary accession number P06282
Secondary accession number Q2M8L4
Integrated into Swiss-Prot on January 1, 1988
Sequence was last modified on January 1, 1988 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 77)
Name and origin of the protein
Protein name CDP-diacylglycerol pyrophosphatase
Synonyms EC 3.6.1.26
CDP-diacylglycerol phosphatidylhydrolase
CDP-diglyceride hydrolase
Gene name
Name: cdh
OrderedLocusNames: b3918, JW3889
From
Escherichia coli (strain K12) [TaxID: 83333] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2995360 [NCBI, ExPASy, EBI, Israel, Japan]
Icho T., Bulawa C.E., Raetz C.R.H.;
"Molecular cloning and sequencing of the gene for CDP-diglyceride hydrolase of Escherichia coli.";
J. Biol. Chem. 260:12092-12098(1985).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=3158524 [NCBI, ExPASy, EBI, Israel, Japan]
Hellinga H.W., Evans P.R.;
"Nucleotide sequence and high-level expression of the major Escherichia coli phosphofructokinase.";
Eur. J. Biochem. 149:363-373(1985).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / MG1655 / ATCC 47076;
DOI=10.1093/nar/21.15.3391; PubMed=8346018 [NCBI, ExPASy, EBI, Israel, Japan]
Plunkett G. III, Burland V., Daniels D.L., Blattner F.R.;
"Analysis of the Escherichia coli genome. III. DNA sequence of the region from 87.2 to 89.2 minutes.";
Nucleic Acids Res. 21:3391-3398(1993).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / MG1655 / ATCC 47076;
DOI=10.1126/science.277.5331.1453; PubMed=9278503 [NCBI, ExPASy, EBI, Israel, Japan]
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.;
"The complete genome sequence of Escherichia coli K-12.";
Science 277:1453-1474(1997).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
DOI=10.1038/msb4100049; PubMed=16738553 [NCBI, ExPASy, EBI, Israel, Japan]
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.";
Mol. Syst. Biol. 2:E1-E5(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M11331; AAA23543.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X02519; CAA26358.1; ALT_FRAME; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L19201; AAB03050.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U00096; AAC76900.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AP009048; BAE77392.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A01019; PSECCD.
RefSeq AP_003891.1; -.
NP_418353.1; -.
3D structure databases
ModBase P06282.
Enzyme and pathway databases
BioCyc EcoCyc:CDPDIGLYPYPHOSPHA-MON; -.
MetaCyc:CDPDIGLYPYPHOSPHA-MON; -.
Organism-specific databases
EchoBASE EB0136; -.
EcoGene EG10138; cdh.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005886; Cellular component: plasma membrane (inferred from electronic annotation from HAMAP).
GO:0008715; Molecular function: CDP-diacylglycerol diphosphatase activity (inferred from electronic annotation from HAMAP).
GO:0008654; Biological process: phospholipid biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00319; -; 1.
PBIL [Tree]
InterPro IPR003763; CDP-diacylglyc_Pase_bac.
IPR015993; CDP-diacylglyc_Pase_proteobac.
Graphical view of domain structure.
Pfam PF02611; CDH; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF001273; CDH; 1.
TIGRFAMs TIGR00672; cdh; 1.
BLOCKS P06282.
ProtoNet P06282.
Genome annotation databases
GeneID 948410; -.
GenomeReviews U00096_GR; b3918.
AP009048_GR; JW3889.
KEGG ecj:JW3889; -.
eco:b3918; -.
Phylogenomic databases
HOGENOM P06282; -.
Genome annotation databases
CMR P06282; b3918.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell inner membrane; Cell membrane; Complete proteome; Hydrolase; Membrane; Phospholipid biosynthesis; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom To Length Description FTId
CHAIN   1   251  251     CDP-diacylglycerol pyrophosphatase. PRO_0000198573
TRANSMEM   4    24  21     Potential. 
Sequence information
Length: 251 AA [This is the length of the unprocessed precursor] Molecular weight: 28451 Da [This is the MW of the unprocessed precursor] CRC64: F2E704FD5E164779 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKKAGLLFLV MIVIAVVAAG IGYWKLTGEE SDTLRKIVLE ECLPNQQQNQ NPSPCAEVKP 

        70         80         90        100        110        120 
NAGYVVLKDL NGPLQYLLMP TYRINGTESP LLTDPSTPNF FWLAWQARDF MSKKYGQPVP 

       130        140        150        160        170        180 
DRAVSLAINS RTGRTQNHFH IHISCIRPDV RKQLDNNLAN ISSRWLPLPG GLRGHEYLAR 

       190        200        210        220        230        240 
RVTESELVQR SPFMMLAEEV PEAREHMGRY GLAMVRQSDN SFVLLATQRN LLTLNRASAE 

       250 
EIQDHQCEIL R 

P06282 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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