NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=910N;
DOI=10.1093/nar/15.7.2945; PubMed=3031615 [NCBI, ExPASy, EBI, Israel, Japan]
Suzu S., Sakai Y., Shioda T., Shibuta H.;
"Nucleotide sequence of the bovine parainfluenza 3 virus genome: the genes of the F and HN glycoproteins.";
Nucleic Acids Res. 15:2945-2958(1987).

Comments

FUNCTION: Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity).
FUNCTION: Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins (By similarity).
CATALYTIC ACTIVITY: Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
SUBCELLULAR LOCATION: Virion membrane; Single-pass type II membrane protein (Potential). Cell membrane; Single-pass type II membrane protein (Potential).
SIMILARITY: Belongs to the paramyxoviruses hemagglutinin-neuraminidase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

Y00114; CAA68298.1; -; Genomic_RNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
D84095; BAA12218.1; -; Genomic_RNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

SMR

P06167; 142-572.

ModBase

P06167.

Ontologies

GO:0016021;	Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005886;	Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0055036;	Cellular component: virion membrane (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.

Family and domain databases

InterPro

IPR000665; Hemagglutn-neuramid_glycoprot.
IPR016285; Hemagglutn-neuramid_paramyxo.
Graphical view of domain structure.

Pfam

PF00423; HN; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF001072; Hemagglut-neuramid_paramyxoV; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell membrane; Envelope protein; Glycoprotein; Hemagglutinin; Hydrolase; Membrane; Signal-anchor; Transmembrane; Virion.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 572`	`572`	`Hemagglutinin-neuraminidase.`	`PRO_0000142624`
`TOPO_DOM`	`1 30`	`30`	`Cytoplasmic (Potential).`
`TRANSMEM`	`31 51`	`21`	`Potential.`
`TOPO_DOM`	`52 572`	`521`	`Extracellular (Potential).`
`CARBOHYD`	`308 308`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`351 351`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`448 448`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`523 523`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`570 570`		`N-linked (GlcNAc...) (Potential).`

Sequence information

Length: 572 AA [This is the length of the unprocessed precursor]

Molecular weight: 64590 Da [This is the MW of the unprocessed precursor]

CRC64: DDF84E90C4EC87B4 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MEYWKHTNST KDTNNELGTT RDRHSSKATN IIMYIFWTTT STILSVIFIM ILINLIQENN 

        70         80         90        100        110        120 
HNKLMLQEIR KEFAAIDTKI QKTSDDIGTS IQSGINTRLL TIQSHVQNYI PLSLTQQMSD 

       130        140        150        160        170        180 
LRKFINDLTT KREHQEVPIQ RMTHDSGIEP LNPDKFWRCT SGNPSLTSSP KIRLIPGPGL 

       190        200        210        220        230        240 
LATSTTVNGC IRLPSLAINN LIYAYTSNLI TQGCQDIGKS YQVLQIGIIT INSDLVPDLN 

       250        260        270        280        290        300 
PRVTHTFNID DNRKSCSLAL LNTDVYQLCS TPKVDERSDY ASTGIEDIVL DIVTSNGLII 

       310        320        330        340        350        360 
TTRFTNNNIT FDKPYAALYP SVGPGIYYKD KVIFLGYGGL EHEENGDVIC NTTGCPGKTQ 

       370        380        390        400        410        420 
RDCNQASYSP WFSNRRMVNS IIVVDKGIDT TFSLRVWTIP MRQNYWGSEG RLLLLGDRIY 

       430        440        450        460        470        480 
IYTRSTSWHS KLQLGVIDIS DFNNIRINWT WHNVLSRPGN DECPWGHSCP DGCITGVYTD 

       490        500        510        520        530        540 
AYPLNPSGSI VSSVILDSQK SRENPIITYS TATNRVNELA IYNRTLPAAY TTTNCITHYD 

       550        560        570 
KGYCFHIVEI NHRSLNTFQP MLFKTEVPKN CS

P06167 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools