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UniProtKB/Swiss-Prot entry P06028


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GLPB_HUMAN
Primary accession number P06028
Secondary accession numbers Q0VAF4 Q58HE9 Q58HF0 Q58HF1 Q9UCH7
Integrated into Swiss-Prot on August 13, 1987
Sequence was last modified on January 1, 1990 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 94)
Name and origin of the protein
Protein name Glycophorin-B [Precursor]
Synonyms PAS-3
Sialoglycoprotein delta
SS-active sialoglycoprotein
CD235b antigen
Gene name
Name: GYPB
Synonyms: GPB
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1073/pnas.84.19.6735; PubMed=3477806 [NCBI, ExPASy, EBI, Israel, Japan]
Siebert P.D., Fukuda M.;
"Molecular cloning of a human glycophorin B cDNA: nucleotide sequence and genomic relationship to glycophorin A.";
Proc. Natl. Acad. Sci. U.S.A. 84:6735-6739(1987).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT SER-84.
PubMed=3196288 [NCBI, ExPASy, EBI, Israel, Japan]
Tate C.G., Tanner M.J.A.;
"Isolation of cDNA clones for human erythrocyte membrane sialoglycoproteins alpha and delta.";
Biochem. J. 254:743-750(1988).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1073/pnas.86.12.4619; PubMed=2734312 [NCBI, ExPASy, EBI, Israel, Japan]
Kudo S., Fukuda M.;
"Structural organization of glycophorin A and B genes: glycophorin B gene evolved by homologous recombination at Alu repeat sequences.";
Proc. Natl. Acad. Sci. U.S.A. 86:4619-4623(1989).
[4]
NUCLEOTIDE SEQUENCE [MRNA], VARIANT M(V) SER-22, VARIANTS MIT MET-48 AND HIS-54, AND VARIANT S(D) ARG-58.
TISSUE=Blood;
DOI=10.1046/j.1537-2995.2001.41020269.x; PubMed=11239234 [NCBI, ExPASy, EBI, Israel, Japan]
Storry J.R., Reid M.E., MacLennan S., Lubenko A., Nortman P.;
"The low-incidence MNS antigens M(v), s(D), and Mit arise from single amino acid substitutions on GPB.";
Transfusion 41:269-275(2001).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT SER-84.
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 13-58.
TISSUE=Blood;
PubMed=2016325 [NCBI, ExPASy, EBI, Israel, Japan]
Huang C.-H., Blumenfeld O.O.;
"Molecular genetics of human erythrocyte MiIII and MiVI glycophorins. Use of a pseudoexon in construction of two delta-alpha-delta hybrid genes resulting in antigenic diversification.";
J. Biol. Chem. 266:7248-7255(1991).
[7]
PROTEIN SEQUENCE OF 20-90.
DOI=10.1111/j.1432-1033.1987.tb13479.x; PubMed=3595615 [NCBI, ExPASy, EBI, Israel, Japan]
Dahr W., Beyreuther K., Moulds J., Unger P.;
"Hybrid glycophorins from human erythrocyte membranes. I. Isolation and complete structural analysis of the hybrid sialoglycoprotein from Dantu-positive red cells of the N.E. variety.";
Eur. J. Biochem. 166:31-36(1987).
[8]
PROTEIN SEQUENCE OF 20-90.
PubMed=3571235 [NCBI, ExPASy, EBI, Israel, Japan]
Blanchard D., Dahr W., Hummel M., Latron F., Beyreuther K., Cartron J.-P.;
"Glycophorins B and C from human erythrocyte membranes. Purification and sequence analysis.";
J. Biol. Chem. 262:5808-5811(1987).
[9]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 20-45.
PubMed=1611092 [NCBI, ExPASy, EBI, Israel, Japan]
Huang C.-H., Spruell P., Moulds J.J., Blumenfeld O.O.;
"Molecular basis for the human erythrocyte glycophorin specifying the Miltenberger class I (MiI) phenotype.";
Blood 80:257-263(1992).
[10]
PROTEIN SEQUENCE OF 20-40, AND GLYCOSYLATION AT THR-36 AND SER-38.
DOI=10.1073/pnas.90.6.2495; PubMed=7681597 [NCBI, ExPASy, EBI, Israel, Japan]
Nakada H., Inoue M., Numata Y., Tanaka N., Funakoshi I., Fukui S., Mellors A., Yamashina I.;
"Epitopic structure of Tn glycophorin A for an anti-Tn antibody (MLS 128).";
Proc. Natl. Acad. Sci. U.S.A. 90:2495-2499(1993).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
J02982; AAA52573.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X08055; CAB42645.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M24137; AAA58626.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M24130; AAA58626.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M24131; AAA58626.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M24135; AAA58626.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY950609; AAX53130.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY950610; AAX53131.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY950611; AAX53132.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC069310; AAH69310.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC121077; AAI21078.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC121078; AAI21079.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M60708; AAC63048.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00024995; -.
PIR B33931; B33931.
RefSeq NP_002091.2; -.
UniGene Hs.654368
3D structure databases
HSSP P02724; 1AFO. [HSSP ENTRY / PDB]
ModBase P06028.
PTM databases
GlycoSuiteDB P06028; -.
Organism-specific databases
GeneCards GC04M145136; -.
HGNC HGNC:4703; GYPB.
GenAtlas GYPB.
MIM 111740; gene+phenotype. [NCBI / EBI]
PharmGKB PA29081; -.
Gene expression databases
CleanEx HS_GYPB; -.
GermOnline ENSG00000153143; Homo sapiens.
Ontologies
GO
GO:0005887; Cellular component: integral to plasma membrane (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR001195; Glycophorin.
IPR018938; Glycophorin_CS.
Graphical view of domain structure.
PANTHER PTHR13813; Glycophorin_A_B; 1.
Pfam PF01102; Glycophorin_A; 1.
Pfam graphical view of domain structure.
PROSITE PS00312; GLYCOPHORIN_A; 1.
Proteomic databases
PRIDE P06028; -.
Genome annotation databases
GeneID 2994; -.
KEGG hsa:2994; -.
Phylogenomic databases
HOVERGEN P06028; -.
Other
NextBio 11866; -.
SOURCE GYPB; Homo sapiens.
ProtoNet P06028.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Blood group antigen; Cell membrane; Direct protein sequencing; Glycoprotein; Membrane; Polymorphism; Sialic acid; Signal; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom  To Length Description FTId
SIGNAL   1   19  19      
CHAIN   20   91  72     Glycophorin-B. PRO_0000012136
TOPO_DOM   20   59  40     Extracellular (Potential). 
TRANSMEM   60   81  22     Potential. 
TOPO_DOM   82   91  10     Cytoplasmic (Potential). 
SITE   33   33  1     Not glycosylated. 
SITE   34   34  1     Not glycosylated. 
CARBOHYD   36   36        O-linked (GlcNAc...). 
CARBOHYD   38   38        O-linked (GlcNAc...). 
VARIANT   22   22  1     T -> S (in M(v) antigen). VAR_047948 
VARIANT   48   48  1     T -> M (in S antigen and Mit antigen; dbSNP:rs7683365 [NCBI]). VAR_003192 
VARIANT   54   54  1     R -> H (in Mit antigen). VAR_047949 
VARIANT   58   58  1     P -> R (in s(D) antigen). VAR_047950 
VARIANT   84   84  1     T -> S (in dbSNP:rs1132783 [NCBI]). VAR_030785 
CONFLICT   69   69        C -> S (in Ref. 7; AA sequence and 8; AA sequence). 
Sequence information
Length: 91 AA [This is the length of the unprocessed precursor] Molecular weight: 9796 Da [This is the MW of the unprocessed precursor] CRC64: F415A64BAA929B7F [This is a checksum on the sequence]
        10         20         30         40         50         60 
MYGKIIFVLL LSEIVSISAL STTEVAMHTS TSSSVTKSYI SSQTNGETGQ LVHRFTVPAP 

        70         80         90 
VVIILIILCV MAGIIGTILL ISYTIRRLIK A 

P06028 in FASTA format

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