ID   ORF2A_CMVQ              Reviewed;         839 AA.
AC   P06012;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   04-NOV-2008, entry version 47.
DE   RecName: Full=RNA-directed RNA polymerase 2A;
DE            Short=protein 2A;
DE            EC=2.7.7.48;
GN   Name=RNA2; ORFNames=ORF2a;
OS   Cucumber mosaic virus (strain Q) (CMV).
OC   Viruses; ssRNA positive-strand viruses, no DNA stage; Bromoviridae;
OC   Cucumovirus.
OX   NCBI_TaxID=12310;
OH   NCBI_TaxID=3659; Cucumis sativus (Cucumber).
OH   NCBI_TaxID=4097; Nicotiana tabacum (Common tobacco).
OH   NCBI_TaxID=4081; Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   MEDLINE=84285410; PubMed=6547906;
RA   Rezaian M.A., Williams R.H.V., Gordon K.H.J., Gould A.R., Symons R.H.;
RT   "Nucleotide sequence of cucumber mosaic virus RNA 2 reveals a
RT   translation product significantly homologous to corresponding proteins
RT   of other viruses.";
RL   Eur. J. Biochem. 143:277-284(1984).
CC   -!- FUNCTION: RNA-directed RNA polymerase.
CC   -!- CATALYTIC ACTIVITY: Nucleoside triphosphate + RNA(n) = diphosphate
CC       + RNA(n+1).
CC   -!- MISCELLANEOUS: The virus has a tripartite genome (RNA1, RNA2 and
CC       RNA3) and an encapsidated subgenomic RNA (RNA4) from which the
CC       coat protein is expressed. Virions are icosahedral, not enveloped,
CC       with 32 capsomers per nucleocapsid.
CC   -!- SIMILARITY: Belongs to the cucumoviruses/bromoviruses 2A family.
CC   -!- SIMILARITY: Contains 1 RdRp catalytic domain.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; X00985; CAA25494.1; -; Genomic_RNA.
DR   PIR; S07226; S07226.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0006410; P:transcription, RNA-dependent; IEA:UniProtKB-KW.
DR   InterPro; IPR001788; RNA-dep_RNA_pol_vir-typ.
DR   InterPro; IPR007094; RNA_pol_PSvir.
DR   Pfam; PF00978; RdRP_2; 1.
DR   PROSITE; PS50507; RDRP_SSRNA_POS; 1.
PE   3: Inferred from homology;
KW   Nucleotide-binding; Nucleotidyltransferase; RNA replication;
KW   RNA-directed RNA polymerase; Transferase.
FT   CHAIN         1    839       RNA-directed RNA polymerase 2A.
FT                                /FTId=PRO_0000083280.
FT   DOMAIN      508    621       RdRp catalytic.
SQ   SEQUENCE   839 AA;  94440 MW;  42C8E0B9D56A8BD9 CRC64;
     MISPPPTFSF ANLLNGSYGV DTPEEVERVR REQREDAEAA LRNYKPLPAV DVSESVPRDE
     PIVSQTVTAA PVTSVDDAFV SFGAEDYLEM SPSELLSAFE LMVKPLRVGE VLCSSFDRSL
     FISSVAMART LLLAPLTSTR TLKRFEDLVA AIYLKTDFFL EDDGPQTDVS QSDVPGYIFE
     PGQHSSGFEP PPICAKCDLI LYQCPCFDFN ALRESCAEKT FSHDYVIEGL DGVIDNATLL
     SNLGPFLLPV HCSYSKTEDP DFVVDPSLAR PTDRVDVHVV QAVCDTTLPT HGNYDDSFHQ
     VFVDSADYST DMDHVRLRQS DLVAKIPDGG HMLPVLNTGS GHQRVGTTKE VLTAIKKRNA
     DVPELGDSVN LSRLSKAVAE RFRLSYMNVD ALAKSNFVNV VSNFHAYMQK WPSSGLSYDD
     LPDLHAENLQ FYDHMIKSDV KPVVTDTLNV DRPVPATITF HKKTITSQFS PLFISLFERF
     QRCLRERVVL PVGKISSLEM TGFSVLNKHC LEIDLSKFDK SQGEFHLMIQ EHILNDLGCP
     APITKWWCDF HRFSYIKDKR AGVGMPISFQ RRTGDAFTYF GNTIVTMAEF AWCYDTDQFD
     RLLFSGDDSL AFSKLPPVGD PSKFTTLFNM EAKVMEPAVP YICSKFYSLM SLVTRFQSPT
     IREIQRLGTK KIPYSDNNDF LFAHFMSFVD RLKFMDRMSQ SCIDQLSIFF ELKYKKSGNE
     AALVLGAFKK YTANFNAYKE LYYSDRQQCD LVNTFCISEF RVIRRTTVKK KKNGCVDSSG
     VDRRPPLSQF AGGETSKTKV SRQKPASEGL QKSQRESAIY SETFPDVTIP RSRSRGLVS
//