Cucumis sativus (Cucumber) [TaxID: 3659]
Nicotiana tabacum (Common tobacco) [TaxID: 4097]
Solanum lycopersicum (Tomato) (Lycopersicon esculentum) [TaxID: 4081]

Protein existence

3: Inferred from homology;

References

[1]

NUCLEOTIDE SEQUENCE [GENOMIC RNA].
PubMed=6547906 [NCBI, ExPASy, EBI, Israel, Japan]
Rezaian M.A., Williams R.H.V., Gordon K.H.J., Gould A.R., Symons R.H.;
"Nucleotide sequence of cucumber mosaic virus RNA 2 reveals a translation product significantly homologous to corresponding proteins of other viruses.";
Eur. J. Biochem. 143:277-284(1984).

Comments

FUNCTION: RNA-directed RNA polymerase.
CATALYTIC ACTIVITY: Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
MISCELLANEOUS: The virus has a tripartite genome (RNA1, RNA2 and RNA3) and an encapsidated subgenomic RNA (RNA4) from which the coat protein is expressed. Virions are icosahedral, not enveloped, with 32 capsomers per nucleocapsid.
SIMILARITY: Belongs to the cucumoviruses/bromoviruses 2A family.
SIMILARITY: Contains 1 RdRp catalytic domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X00985; CAA25494.1; -; Genomic_RNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S07226; S07226.

3D structure databases

ModBase

P06012.

Family and domain databases

InterPro

IPR001788; RNA-dep_RNA_pol_vir-typ.
IPR007094; RNA_pol_PSvir.
Graphical view of domain structure.

Pfam

PF00978; RdRP_2; 1.
Pfam graphical view of domain structure.

PROSITE

PS50507; RDRP_SSRNA_POS; 1.
PROSITE graphical view of domain structure (profiles).

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Nucleotide-binding; Nucleotidyltransferase; RNA replication; RNA-directed RNA polymerase; Transferase.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 839`	`839`	`RNA-directed RNA polymerase 2A.`	`PRO_0000083280`
`DOMAIN`	`508 621`	`114`	`RdRp catalytic.`

Sequence information

Length: 839 AA [This is the length of the unprocessed precursor]

Molecular weight: 94440 Da [This is the MW of the unprocessed precursor]

CRC64: 42C8E0B9D56A8BD9 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MISPPPTFSF ANLLNGSYGV DTPEEVERVR REQREDAEAA LRNYKPLPAV DVSESVPRDE 

        70         80         90        100        110        120 
PIVSQTVTAA PVTSVDDAFV SFGAEDYLEM SPSELLSAFE LMVKPLRVGE VLCSSFDRSL 

       130        140        150        160        170        180 
FISSVAMART LLLAPLTSTR TLKRFEDLVA AIYLKTDFFL EDDGPQTDVS QSDVPGYIFE 

       190        200        210        220        230        240 
PGQHSSGFEP PPICAKCDLI LYQCPCFDFN ALRESCAEKT FSHDYVIEGL DGVIDNATLL 

       250        260        270        280        290        300 
SNLGPFLLPV HCSYSKTEDP DFVVDPSLAR PTDRVDVHVV QAVCDTTLPT HGNYDDSFHQ 

       310        320        330        340        350        360 
VFVDSADYST DMDHVRLRQS DLVAKIPDGG HMLPVLNTGS GHQRVGTTKE VLTAIKKRNA 

       370        380        390        400        410        420 
DVPELGDSVN LSRLSKAVAE RFRLSYMNVD ALAKSNFVNV VSNFHAYMQK WPSSGLSYDD 

       430        440        450        460        470        480 
LPDLHAENLQ FYDHMIKSDV KPVVTDTLNV DRPVPATITF HKKTITSQFS PLFISLFERF 

       490        500        510        520        530        540 
QRCLRERVVL PVGKISSLEM TGFSVLNKHC LEIDLSKFDK SQGEFHLMIQ EHILNDLGCP 

       550        560        570        580        590        600 
APITKWWCDF HRFSYIKDKR AGVGMPISFQ RRTGDAFTYF GNTIVTMAEF AWCYDTDQFD 

       610        620        630        640        650        660 
RLLFSGDDSL AFSKLPPVGD PSKFTTLFNM EAKVMEPAVP YICSKFYSLM SLVTRFQSPT 

       670        680        690        700        710        720 
IREIQRLGTK KIPYSDNNDF LFAHFMSFVD RLKFMDRMSQ SCIDQLSIFF ELKYKKSGNE 

       730        740        750        760        770        780 
AALVLGAFKK YTANFNAYKE LYYSDRQQCD LVNTFCISEF RVIRRTTVKK KKNGCVDSSG 

       790        800        810        820        830 
VDRRPPLSQF AGGETSKTKV SRQKPASEGL QKSQRESAIY SETFPDVTIP RSRSRGLVS

P06012 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools