ID CASB_HUMAN Reviewed; 226 AA. AC P05814; Q4VAZ9; DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot. DT 01-AUG-1992, sequence version 4. DT 04-NOV-2008, entry version 81. DE RecName: Full=Beta-casein; DE Flags: Precursor; GN Name=CSN2; Synonyms=CASB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Mammary gland; RA Menon R.S.; RL Submitted (OCT-1989) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=90353560; PubMed=2387396; DOI=10.1016/0014-5793(90)81142-B; RA Loennerdal B., Bergstroem S., Andersson Y., Hjalmarsson K., RA Sundqvist A.K., Hernell O.; RT "Cloning and sequencing of a cDNA encoding human milk beta-casein."; RL FEBS Lett. 269:153-156(1990). RN [3] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Placenta; RX MEDLINE=94156198; PubMed=8112603; DOI=10.1016/0378-1119(94)90754-4; RA Hansson L., Edlund A., Johansson T., Hernell O., Stroemqvist M., RA Lindquist S., Loennerdal B., Bergstroem S.; RT "Structure of the human beta-casein encoding gene."; RL Gene 139:193-199(1994). RN [4] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Placenta; RA Kwiatkowski D.J.; RL Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [6] RP NUCLEOTIDE SEQUENCE [MRNA] OF 161-226. RC TISSUE=Mammary gland; RX MEDLINE=89240053; PubMed=2717418; DOI=10.1093/nar/17.7.2869; RA Menon R.S., Ham R.G.; RT "Human beta-casein: partial cDNA sequence and apparent polymorphism."; RL Nucleic Acids Res. 17:2869-2869(1989). RN [7] RP PROTEIN SEQUENCE OF 16-226, AND PHOSPHORYLATION AT THR-18; SER-21; RP SER-23; SER-24 AND SER-25. RX MEDLINE=84185624; PubMed=6715339; RA Greenberg R., Groves M.L., Dower H.J.; RT "Human beta-casein. Amino acid sequence and identification of RT phosphorylation sites."; RL J. Biol. Chem. 259:5132-5138(1984). CC -!- FUNCTION: Important role in determination of the surface CC properties of the casein micelles. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk. CC -!- PTM: Form 1-P is phosphorylated once; half of the molecules are CC phosphorylated on Ser-24, half on Ser-25. CC -!- SIMILARITY: Belongs to the beta-casein family. CC -!- WEB RESOURCE: Name=Protein Spotlight; Note=Of buttons, digestion CC and glue - Issue 16 of November 2001; CC URL="http://www.expasy.org/spotlight/back_issues/sptlt016.shtml"; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; X17070; CAA34916.1; -; mRNA. DR EMBL; X13766; CAA32017.1; -; mRNA. DR EMBL; AF027807; AAC82978.1; -; Genomic_DNA. DR EMBL; BC069554; AAH69554.1; -; mRNA. DR EMBL; BC096194; AAH96194.1; -; mRNA. DR EMBL; BC096195; AAH96195.1; -; mRNA. DR EMBL; BC096196; AAH96196.1; -; mRNA. DR EMBL; BC096197; AAH96197.1; -; mRNA. DR EMBL; X55739; CAA39270.1; -; mRNA. DR PIR; I53730; KBHU. DR RefSeq; NP_001882.1; -. DR UniGene; Hs.2242; -. DR DisProt; DP00199; -. DR DIP; DIP:528N; -. DR PhosphoSite; P05814; -. DR Ensembl; ENSG00000135222; Homo sapiens. DR GeneID; 1447; -. DR KEGG; hsa:1447; -. DR H-InvDB; HIX0031475; -. DR HGNC; HGNC:2447; CSN2. DR MIM; 115460; gene. DR PharmGKB; PA26950; -. DR HOGENOM; P05814; -. DR HOVERGEN; P05814; -. DR NextBio; 5947; -. DR ArrayExpress; P05814; -. DR CleanEx; HS_CSN2; -. DR GermOnline; ENSG00000135222; Homo sapiens. DR GO; GO:0005509; F:calcium ion binding; TAS:ProtInc. DR GO; GO:0004857; F:enzyme inhibitor activity; TAS:ProtInc. DR GO; GO:0006816; P:calcium ion transport; TAS:ProtInc. DR InterPro; IPR001588; Casein. DR InterPro; IPR016345; Casein_beta. DR Pfam; PF00363; Casein; 1. DR PIRSF; PIRSF002372; Beta-casein; 1. DR PROSITE; PS00306; CASEIN_ALPHA_BETA; 1. PE 1: Evidence at protein level; KW Direct protein sequencing; Milk protein; Phosphoprotein; Secreted; KW Signal. FT SIGNAL 1 15 FT CHAIN 16 226 Beta-casein. FT /FTId=PRO_0000004475. FT MOD_RES 18 18 Phosphothreonine; in form 5-P. FT MOD_RES 21 21 Phosphoserine; in form 4-P and form 5-P. FT MOD_RES 23 23 Phosphoserine; in form 3-P, form 4-P and FT form 5-P. FT MOD_RES 24 24 Phosphoserine; in form 1-P, form 2-P, FT form 3-P, form 4-P and form 5-P. FT MOD_RES 25 25 Phosphoserine; in form 1-P, form 2-P, FT form 3-P, form 4-P and form 5-P. FT CONFLICT 30 30 T -> P (in Ref. 7; AA sequence). FT CONFLICT 34 34 Missing (in Ref. 2; CAA39270). FT CONFLICT 48 50 EDE -> TDQ (in Ref. 7; AA sequence). FT CONFLICT 120 120 S -> Q (in Ref. 7; AA sequence). FT CONFLICT 133 133 L -> V (in Ref. 1). FT CONFLICT 140 140 H -> Q (in Ref. 1). FT CONFLICT 149 149 L -> S (in Ref. 7; AA sequence). FT CONFLICT 173 173 Q -> E (in Ref. 7; AA sequence). FT CONFLICT 182 184 QVV -> EVL (in Ref. 7; AA sequence). FT CONFLICT 188 188 Q -> V (in Ref. 7; AA sequence). FT CONFLICT 207 207 T -> P (in Ref. 7; AA sequence). FT CONFLICT 214 222 TQPLAPVHN -> PEPSTTZABH (in Ref. 7; AA FT sequence). SQ SEQUENCE 226 AA; 25382 MW; 2619C524EA1358E8 CRC64; MKVLILACLV ALALARETIE SLSSSEESIT EYKQKVEKVK HEDQQQGEDE HQDKIYPSFQ PQPLIYPFVE PIPYGFLPQN ILPLAQPAVV LPVPQPEIME VPKAKDTVYT KGRVMPVLKS PTIPFFDPQI PKLTDLENLH LPLPLLQPLM QQVPQPIPQT LALPPQPLWS VPQPKVLPIP QQVVPYPQRA VPVQALLLNQ ELLLNPTHQI YPVTQPLAPV HNPISV //