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UniProtKB/Swiss-Prot entry P05814

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CASB_HUMAN
Primary accession number P05814
Secondary accession number Q4VAZ9
Integrated into Swiss-Prot on November 1, 1988
Sequence was last modified on August 1, 1992 (Sequence version 4)
Annotations were last modified on    July 22, 2008 (Entry version 80)
Name and origin of the protein
Protein name Beta-casein [Precursor]
Synonyms None
Gene name
Name: CSN2
Synonyms: CASB
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE.
TISSUE=Mammary gland;
Menon R.S.;
Submitted (OCT-1989) to the EMBL/GenBank/DDBJ databases.
[2]
 NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/0014-5793(90)81142-B; PubMed=2387396 [NCBI, ExPASy, EBI, Israel, Japan]
Loennerdal B., Bergstroem S., Andersson Y., Hjalmarsson K., Sundqvist A.K., Hernell O.;
"Cloning and sequencing of a cDNA encoding human milk beta-casein.";
FEBS Lett. 269:153-156(1990).
[3]
 NUCLEOTIDE SEQUENCE.
TISSUE=Placenta;
DOI=10.1016/0378-1119(94)90754-4; PubMed=8112603 [NCBI, ExPASy, EBI, Israel, Japan]
Hansson L., Edlund A., Johansson T., Hernell O., Stroemqvist M., Lindquist S., Loennerdal B., Bergstroem S.;
"Structure of the human beta-casein encoding gene.";
Gene 139:193-199(1994).
[4]
 NUCLEOTIDE SEQUENCE.
TISSUE=Placenta;
Kwiatkowski D.J.;
Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
[5]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
 NUCLEOTIDE SEQUENCE [MRNA] OF 161-226.
TISSUE=Mammary gland;
DOI=10.1093/nar/17.7.2869; PubMed=2717418 [NCBI, ExPASy, EBI, Israel, Japan]
Menon R.S., Ham R.G.;
"Human beta-casein: partial cDNA sequence and apparent polymorphism.";
Nucleic Acids Res. 17:2869-2869(1989).
[7]
 PROTEIN SEQUENCE OF 16-226, AND PHOSPHORYLATION AT THR-18; SER-21; SER-23; SER-24 AND SER-25.
PubMed=6715339 [NCBI, ExPASy, EBI, Israel, Japan]
Greenberg R., Groves M.L., Dower H.J.;
"Human beta-casein. Amino acid sequence and identification of phosphorylation sites.";
J. Biol. Chem. 259:5132-5138(1984).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X17070; CAA34916.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X13766; CAA32017.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF027807; AAC82978.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC069554; AAH69554.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC096194; AAH96194.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC096195; AAH96195.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC096196; AAH96196.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC096197; AAH96197.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X55739; CAA39270.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR I53730; KBHU.
RefSeq NP_001882.1; -.
UniGene Hs.2242
3D structure databases
DisProt DP00199; -.
ModBase P05814.
Protein-protein interaction databases
DIP DIP:528N; -.
IntAct P05814; -.
PTM databases
PhosphoSite P05814; -.
Organism-specific databases
H-InvDB HIX0031475; -.
HGNC HGNC:2447; CSN2.
GenAtlas CSN2.
MIM 115460; gene. [NCBI / EBI]
PharmGKB PA26950; -.
GeneCards P05814.
Gene expression databases
ArrayExpress P05814; -.
CleanEx HS_CSN2; -.
GermOnline ENSG00000135222; Homo sapiens.
Ontologies
GO
GO:0005509; Molecular function: calcium ion binding (traceable author statement from ProtInc).
GO:0004857; Molecular function: enzyme inhibitor activity (traceable author statement from ProtInc).
GO:0006816; Biological process: calcium ion transport (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR001588; Casein.
IPR016345; Casein_beta.
Graphical view of domain structure.
Pfam PF00363; Casein; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF002372; Beta-casein; 1.
PROSITE PS00306; CASEIN_ALPHA_BETA; 1.
BLOCKS P05814.
Genome annotation databases
Ensembl ENSG00000135222; Homo sapiens. [Contig view]
GeneID 1447; -.
KEGG hsa:1447; -.
Phylogenomic databases
HOGENOM P05814; -.
HOVERGEN P05814; -.
Other
SOURCE CSN2; Homo sapiens.
ProtoNet P05814.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Direct protein sequencing; Milk protein; Phosphoprotein; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
SIGNAL   1    15  15      
CHAIN   16   226  211     Beta-casein. PRO_0000004475
MOD_RES   18    18        Phosphothreonine; in form 5-P. 
MOD_RES   21    21        Phosphoserine; in form 4-P and form 5-P. 
MOD_RES   23    23        Phosphoserine; in form 3-P, form 4-P and form 5-P. 
MOD_RES   24    24        Phosphoserine; in form 1-P, form 2-P, form 3-P, form 4-P and form 5-P. 
MOD_RES   25    25        Phosphoserine; in form 1-P, form 2-P, form 3-P, form 4-P and form 5-P. 
CONFLICT   30    30        T -> P (in Ref. 7; AA sequence). 
CONFLICT   34    34        Missing (in Ref. 2; CAA39270). 
CONFLICT   48    50        EDE -> TDQ (in Ref. 7; AA sequence). 
CONFLICT   120   120        S -> Q (in Ref. 7; AA sequence). 
CONFLICT   133   133        L -> V (in Ref. 1). 
CONFLICT   140   140        H -> Q (in Ref. 1). 
CONFLICT   149   149        L -> S (in Ref. 7; AA sequence). 
CONFLICT   173   173        Q -> E (in Ref. 7; AA sequence). 
CONFLICT   182   184        QVV -> EVL (in Ref. 7; AA sequence). 
CONFLICT   188   188        Q -> V (in Ref. 7; AA sequence). 
CONFLICT   207   207        T -> P (in Ref. 7; AA sequence). 
CONFLICT   214   222        TQPLAPVHN -> PEPSTTZABH (in Ref. 7; AA sequence). 
Sequence information
Length: 226 AA [This is the length of the unprocessed precursor] Molecular weight: 25382 Da [This is the MW of the unprocessed precursor] CRC64: 2619C524EA1358E8 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKVLILACLV ALALARETIE SLSSSEESIT EYKQKVEKVK HEDQQQGEDE HQDKIYPSFQ 

        70         80         90        100        110        120 
PQPLIYPFVE PIPYGFLPQN ILPLAQPAVV LPVPQPEIME VPKAKDTVYT KGRVMPVLKS 

       130        140        150        160        170        180 
PTIPFFDPQI PKLTDLENLH LPLPLLQPLM QQVPQPIPQT LALPPQPLWS VPQPKVLPIP 

       190        200        210        220 
QQVVPYPQRA VPVQALLLNQ ELLLNPTHQI YPVTQPLAPV HNPISV
P05814 in FASTA format

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