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UniProtKB/Swiss-Prot entry P05807


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NTP1_VACCV
Primary accession number P05807
Secondary accession numbers P04313 P04317 Q76ZR6 Q84138
Integrated into Swiss-Prot on March 20, 1987
Sequence was last modified on November 1, 1988 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 61)
Name and origin of the protein
Protein name Nucleoside triphosphatase I
Synonyms EC 3.6.1.15
Nucleoside triphosphate phosphohydrolase I
NPH I
Factor X
Gene name
Name: NPH1
OrderedLocusNames: VACWR116
ORFNames: D11L, D15
From
Vaccinia virus (strain Western Reserve / WR) (VACV) [TaxID: 10254] 
Taxonomy Viruses; dsDNA viruses, no RNA stage; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
Virus host Homo sapiens (Human) [TaxID: 9606]
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=3025846 [NCBI, ExPASy, EBI, Israel, Japan]
Rodriguez J.F., Kahn J.S., Esteban M.;
"Molecular cloning, encoding sequence, and expression of vaccinia virus nucleic acid-dependent nucleoside triphosphatase gene.";
Proc. Natl. Acad. Sci. U.S.A. 83:9566-9570(1986).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/0042-6822(86)90011-5; PubMed=3739227 [NCBI, ExPASy, EBI, Israel, Japan]
Niles E.G., Condit R.C., Caro P., Davidson K., Matusick L., Seto J.;
"Nucleotide sequence and genetic map of the 16-kb vaccinia virus HindIII D fragment.";
Virology 153:96-112(1986).
[3]
SEQUENCE REVISION.
Niles E.G.;
Submitted (FEB-1988) to the PIR data bank.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Esposito J.J., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Osborne J., Wohlhueter R.;
"Sequencing of the coding region of Vaccinia-WR to an average 9-fold redundancy and an error rate of 0.16/10kb.";
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-288.
DOI=10.1093/nar/14.7.3003; PubMed=3008103 [NCBI, ExPASy, EBI, Israel, Japan]
Weinrich S.L., Hruby D.E.;
"A tandemly-oriented late gene cluster within the vaccinia virus genome.";
Nucleic Acids Res. 14:3003-3016(1986).
[6]
CHARACTERIZATION.
PubMed=9472022 [NCBI, ExPASy, EBI, Israel, Japan]
Deng L., Shuman S.;
"Vaccinia NPH-I, a DExH-box ATPase, is the energy coupling factor for mRNA transcription termination.";
Genes Dev. 12:538-546(1998).
[7]
MUTAGENESIS.
PubMed=9882335 [NCBI, ExPASy, EBI, Israel, Japan]
Martins A., Gross C.H., Shuman S.;
"Mutational analysis of vaccinia virus nucleoside triphosphate phosphohydrolase I, a DNA-dependent ATPase of the DExH box family.";
J. Virol. 73:1302-1308(1999).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M14629; AAA48301.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M15058; AAA48267.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY243312; AAO89395.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X03729; CAA27370.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A94144; NPVZ17.
RefSeq YP_232998.1; -.
3D structure databases
ModBase P05807.
Ontologies
GO
GO:0006350; Biological process: transcription (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR014001; DEAD-like_N.
IPR001650; DNA/RNA_helicase_C.
IPR014021; Helicase_SF1/SF2_ATP-bd.
IPR013676; NPHI_C.
IPR000330; SNF2_N.
Graphical view of domain structure.
Pfam PF00271; Helicase_C; 1.
PF08469; NPHI_C; 1.
PF00176; SNF2_N; 1.
Pfam graphical view of domain structure.
SMART SM00487; DEXDc; 1.
SM00490; HELICc; 1.
SMART graphical view of domain structure.
PROSITE PS51192; HELICASE_ATP_BIND_1; 1.
PS51194; HELICASE_CTER; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P05807.
ProtoNet P05807.
Genome annotation databases
GeneID 3707708; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Hydrolase; Late protein; Nucleotide-binding; Transcription.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   631  631     Nucleoside triphosphatase I. PRO_0000099092
DOMAIN   42   204  163     Helicase ATP-binding. 
DOMAIN   367   532  166     Helicase C-terminal. 
NP_BIND   55    62  8     ATP. 
MOTIF   141   144  4     DEXH box. 
MUTAGEN   61    61        K->A: Abolishes ATP hydrolysis. 
Sequence information
Length: 631 AA [This is the length of the unprocessed precursor] Molecular weight: 72310 Da [This is the MW of the unprocessed precursor] CRC64: 76DE4A45F0AF00D0 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSKSHAAYID YALRRTTNMP VEMMGSDVVR LKDYQHFVAR VFLGLDSMHS LLLFHETGVG 

        70         80         90        100        110        120 
KTMTTVYILK HLKDIYTNWA IILLVKKALI EDPWMNTILR YAPEITKDCI FINYDDQNFR 

       130        140        150        160        170        180 
NKFFTNIKTI NSKSRICVII DECHNFISKS LIKEDGKIRP TRSVYNFLSK TIALKNHKMI 

       190        200        210        220        230        240 
CLSATPIVNS VQEFTMLVNL LRPGSLQHQS LFENKRLVDE KELVSKLGGL CSYIVNNEFS 

       250        260        270        280        290        300 
IFDDVEGSAS FAKKTVLMRY VNMSKKQEEI YQKAKLAEIK TGISSFRILR RMATTFTFDS 

       310        320        330        340        350        360 
FPERQNRDPG EYAQEIATLY NDFKNSLRDR EFSKSALDTF KRGELLGGDA SAADISLFTE 

       370        380        390        400        410        420 
LKEKSVKFID VCLGILASHG KCLVFEPFVN QSGIEILLLY FKVFGISNIE FSSRTKDTRI 

       430        440        450        460        470        480 
KAVAEFNQES NTNGECIKTC VFSSSGGEGI SFFSINDIFI LDMTWNEASL RQIVGRAIRL 

       490        500        510        520        530        540 
NSHVLTPPER RYVNVHFIMA RLSNGMPTVD EDLFEIIQSK SKEFVQLFRV FKHTSLEWIH 

       550        560        570        580        590        600 
ANEKDFSPID NESGWKTLVS RAIDLSSNKN ITNKLIEGTN IWYSNSNRLM SINRGFKGVD 

       610        620        630 
GRVYDVDGNY LHDMPDNPVI KIHDGKLIYI F 

P05807 in FASTA format

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