[1]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/0378-1119(90)90285-Y; PubMed=1691124 [NCBI, ExPASy, EBI, Israel, Japan]
Krauss S.,
Franke W.W.;
"Organization and sequence of the human gene encoding cytokeratin 8.";
Gene 86:241-249(1990).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1692965 [NCBI, ExPASy, EBI, Israel, Japan]
Yamamoto R.,
Kao L.C.,
McKnight C.E.,
Strauss J.F. III;
"Cloning and sequence of cDNA for human placental cytokeratin 8. Regulation of the mRNA in trophoblastic cells by cAMP.";
Mol. Endocrinol. 4:370-374(1990).
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[3]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
TISSUE=Placenta;
PubMed=1705144 [NCBI, ExPASy, EBI, Israel, Japan]
Waseem A.,
Alexander C.M.,
Steel J.B.,
Lane E.B.;
"Embryonic simple epithelial keratins 8 and 18: chromosomal location emphasizes difference from other keratin pairs.";
New Biol. 2:464-478(1990).
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[4]
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NUCLEOTIDE SEQUENCE [MRNA], AND PHOSPHORYLATION AT SER-24 AND SER-432.
DOI=10.1074/jbc.272.11.7556; PubMed=9054461 [NCBI, ExPASy, EBI, Israel, Japan]
Ku N.-O.,
Omary M.B.;
"Phosphorylation of human keratin 8 in vivo at conserved head domain serine 23 and at epidermal growth factor-stimulated tail domain serine 431.";
J. Biol. Chem. 272:7556-7564(1997).
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[5]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney;
Suzuki Y.,
Sugano S.,
Totoki Y.,
Toyoda A.,
Takeda T.,
Sakaki Y.,
Tanaka A.,
Yokoyama S.;
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
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[6]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT CYS-62.
TISSUE=Colon, Liver, Lung, and Placenta;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[7]
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NUCLEOTIDE SEQUENCE [MRNA] OF 1-231.
PubMed=2471065 [NCBI, ExPASy, EBI, Israel, Japan]
Kulesh D.A.,
Cecena G.,
Darmon Y.M.,
Vasseur M.,
Oshima R.G.;
"Posttranslational regulation of keratins: degradation of mouse and human keratins 18 and 8.";
Mol. Cell. Biol. 9:1553-1565(1989).
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[8]
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NUCLEOTIDE SEQUENCE [MRNA] OF 205-483.
PubMed=2434381 [NCBI, ExPASy, EBI, Israel, Japan]
Leube R.E.,
Bosch F.X.,
Romano V.,
Zimbelmann R.,
Hofler H.,
Franke W.W.;
"Cytokeratin expression in simple epithelia. III. Detection of mRNAs encoding human cytokeratins nos. 8 and 18 in normal and tumor cells by hybridization with cDNA sequences in vitro and in situ.";
Differentiation 33:69-85(1986).
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[9]
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PARTIAL PROTEIN SEQUENCE.
TISSUE=Colon carcinoma;
DOI=10.1002/elps.1150180344; PubMed=9150948 [NCBI, ExPASy, EBI, Israel, Japan]
Ji H.,
Reid G.E.,
Moritz R.L.,
Eddes J.S.,
Burgess A.W.,
Simpson R.J.;
"A two-dimensional gel database of human colon carcinoma proteins.";
Electrophoresis 18:605-613(1997).
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[10]
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GLYCOSYLATION.
PubMed=1371281 [NCBI, ExPASy, EBI, Israel, Japan]
Chou C.F.,
Smith A.J.,
Omary M.B.;
"Characterization and dynamics of O-linked glycosylation of human cytokeratin 8 and 18.";
J. Biol. Chem. 267:3901-3906(1992).
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[11]
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INTERACTION WITH KRT20, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
DOI=10.1016/S0003-9969(00)00050-9; PubMed=10973561 [NCBI, ExPASy, EBI, Israel, Japan]
Barrett A.W.,
Cort E.M.,
Patel P.,
Berkovitz B.K.B.;
"An immunohistological study of cytokeratin 20 in human and mammalian oral epithelium.";
Arch. Oral Biol. 45:879-887(2000).
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[12]
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INTERACTION WITH PNN.
DOI=10.1074/jbc.275.20.14910; PubMed=10809736 [NCBI, ExPASy, EBI, Israel, Japan]
Shi J.,
Sugrue S.P.;
"Dissection of protein linkage between keratins and pinin, a protein with dual location at desmosome-intermediate filament complex and in the nucleus.";
J. Biol. Chem. 275:14910-14915(2000).
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[13]
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PHOSPHORYLATION AT SER-74.
DOI=10.1074/jbc.M111436200; PubMed=11781324 [NCBI, ExPASy, EBI, Israel, Japan]
He T.,
Stepulak A.,
Holmstrom T.H.,
Omary M.B.,
Eriksson J.E.;
"The intermediate filament protein keratin 8 is a novel cytoplasmic substrate for c-Jun N-terminal kinase.";
J. Biol. Chem. 277:10767-10774(2002).
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[14]
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PHOSPHORYLATION AT SER-74, AND MUTAGENESIS OF LEU-72 AND SER-74.
DOI=10.1074/jbc.M107623200; PubMed=11788583 [NCBI, ExPASy, EBI, Israel, Japan]
Ku N.O.,
Azhar S.,
Omary M.B.;
"Keratin 8 phosphorylation by p38 kinase regulates cellular keratin filament reorganization: modulation by a keratin 1-like disease causing mutation.";
J. Biol. Chem. 277:10775-10782(2002).
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[15]
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INTERACTION WITH TCHP.
DOI=10.1242/jcs.01667; PubMed=15731013 [NCBI, ExPASy, EBI, Israel, Japan]
Nishizawa M.,
Izawa I.,
Inoko A.,
Hayashi Y.,
Nagata K.,
Yokoyama T.,
Usukura J.,
Inagaki M.;
"Identification of trichoplein, a novel keratin filament-binding protein.";
J. Cell Sci. 118:1081-1090(2005).
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[16]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21; SER-22; SER-24; SER-37 AND SER-43, AND MASS SPECTROMETRY.
DOI=10.1021/pr050048h; PubMed=16083285 [NCBI, ExPASy, EBI, Israel, Japan]
Kim J.-E.,
Tannenbaum S.R.,
White F.M.;
"Global phosphoproteome of HT-29 human colon adenocarcinoma cells.";
J. Proteome Res. 4:1339-1346(2005).
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[17]
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FUNCTION, SUBUNIT, AND TISSUE SPECIFICITY.
DOI=10.1091/mbc.E05-02-0112; PubMed=16000376 [NCBI, ExPASy, EBI, Israel, Japan]
Stone M.R.,
O'Neill A.,
Catino D.,
Bloch R.J.;
"Specific interaction of the actin-binding domain of dystrophin with intermediate filaments containing keratin 19.";
Mol. Biol. Cell 16:4280-4293(2005).
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[18]
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INTERACTION WITH HCV CORE PROTEIN.
DOI=10.1002/pmic.200401093; PubMed=15846844 [NCBI, ExPASy, EBI, Israel, Japan]
Kang S.-M.,
Shin M.-J.,
Kim J.-H.,
Oh J.-W.;
"Proteomic profiling of cellular proteins interacting with the hepatitis C virus core protein.";
Proteomics 5:2227-2237(2005).
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[19]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-253 AND SER-330, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1016/j.cell.2006.09.026; PubMed=17081983 [NCBI, ExPASy, EBI, Israel, Japan]
Olsen J.V.,
Blagoev B.,
Gnad F.,
Macek B.,
Kumar C.,
Mortensen P.,
Mann M.;
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.";
Cell 127:635-648(2006).
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[20]
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INTERACTION WITH KRT20.
DOI=10.1074/jbc.M512284200; PubMed=16608857 [NCBI, ExPASy, EBI, Israel, Japan]
Zhou Q.,
Cadrin M.,
Herrmann H.,
Chen C.-H.,
Chalkley R.J.,
Burlingame A.L.,
Omary M.B.;
"Keratin 20 serine 13 phosphorylation is a stress and intestinal goblet cell marker.";
J. Biol. Chem. 281:16453-16461(2006).
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[21]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-27, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1038/nbt1240; PubMed=16964243 [NCBI, ExPASy, EBI, Israel, Japan]
Beausoleil S.A.,
Villen J.,
Gerber S.A.,
Rush J.,
Gygi S.P.;
"A probability-based approach for high-throughput protein phosphorylation analysis and site localization.";
Nat. Biotechnol. 24:1285-1292(2006).
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[22]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-451, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1073/pnas.0507066103; PubMed=16565220 [NCBI, ExPASy, EBI, Israel, Japan]
Nousiainen M.,
Sillje H.H.W.,
Sauer G.,
Nigg E.A.,
Koerner R.;
"Phosphoproteome analysis of the human mitotic spindle.";
Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006).
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[23]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-204 AND TYR-267, AND MASS SPECTROMETRY.
DOI=10.1016/j.cell.2007.11.025; PubMed=18083107 [NCBI, ExPASy, EBI, Israel, Japan]
Rikova K.,
Guo A.,
Zeng Q.,
Possemato A.,
Yu J.,
Haack H.,
Nardone J.,
Lee K.,
Reeves C.,
Li Y.,
Hu Y.,
Tan Z.,
Stokes M.,
Sullivan L.,
Mitchell J.,
Wetzel R.,
Macneill J.,
Ren J.M.,
Yuan J., ![]()
Bakalarski C.E.,
Villen J.,
Kornhauser J.M.,
Smith B.,
Li D.,
Zhou X.,
Gygi S.P.,
Gu T.-L.,
Polakiewicz R.D.,
Rush J.,
Comb M.J.;
"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.";
Cell 131:1190-1203(2007).
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[24]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24 AND THR-26, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1021/pr070152u; PubMed=17924679 [NCBI, ExPASy, EBI, Israel, Japan]
Yu L.-R.,
Zhu Z.,
Chan K.C.,
Issaq H.J.,
Dimitrov D.S.,
Veenstra T.D.;
"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
J. Proteome Res. 6:4150-4162(2007).
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[25]
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VARIANTS CRYPTOGENIC CIRRHOSIS VAL-53; CYS-54 AND CYS-62, AND VARIANT VAL-63.
DOI=10.1073/pnas.0936165100; PubMed=12724528 [NCBI, ExPASy, EBI, Israel, Japan]
Ku N.-O.,
Darling J.M.,
Krams S.M.,
Esquivel C.O.,
Keeffe E.B.,
Sibley R.K.,
Lee Y.M.,
Wright T.L.,
Omary M.B.;
"Keratin 8 and 18 mutations are risk factors for developing liver disease of multiple etiologies.";
Proc. Natl. Acad. Sci. U.S.A. 100:6063-6068(2003).
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