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[1]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
PubMed=3670308 [NCBI, ExPASy, EBI, Israel, Japan]
Clarke C.F.,
Tanaka R.D.,
Svenson K.,
Wamsley M.,
Fogelman A.M.,
Edwards P.A.;
"Molecular cloning and sequence of a cholesterol-repressible enzyme related to prenyltransferase in the isoprene biosynthetic pathway.";
Mol. Cell. Biol. 7:3138-3146(1987).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA], AND SEQUENCE REVISION.
STRAIN=Sprague-Dawley;
TISSUE=Testis;
PubMed=2325654 [NCBI, ExPASy, EBI, Israel, Japan]
Teruya J.H.,
Kutsunai S.Y.,
Spear D.H.,
Edwards P.A.,
Clarke C.F.;
"Testis-specific transcription initiation sites of rat farnesyl pyrophosphate synthetase mRNA.";
Mol. Cell. Biol. 10:2315-2326(1990).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT HIS-110.
TISSUE=Pituitary;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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- FUNCTION: Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (By similarity).
- CATALYTIC ACTIVITY: Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
- CATALYTIC ACTIVITY: Geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate.
- ENZYME REGULATION: Inactivated by interferon-induced RSAD2. This inactivation may result of disruption of lipid rafts at the plasma membrane, and thus have an antiviral effect since many envelopped viruses need lipid rafts to bud efficiently out of the cell (By similarity).
- PATHWAY: Isoprenoid biosynthesis; farnesyl-PP biosynthesis; farnesyl-PP from geranyl-PP and isopentenyl-PP: step 1/1.
- PATHWAY: Isoprenoid biosynthesis; geranyl-PP biosynthesis; geranyl-PP from dimethylallyl-PP and isopentenyl-PP: step 1/1.
- SUBUNIT: Homodimer. Interacts with RSAD2 (By similarity).
- SUBCELLULAR LOCATION: Cytoplasm.
- TISSUE SPECIFICITY: Testis, liver, kidney, brain and adrenal gland.
- SIMILARITY: Belongs to the FPP/GGPP synthetase family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 353 AA [This is the length of the unprocessed precursor] |
Molecular weight: 40830 Da [This is the MW of the unprocessed precursor] |
CRC64: 27FD7E0DD6FEA001 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MNGDQKLDVH NQEKQNFIQH FSQIVKVLTE DELGHPEKGD AITRIKEVLE YNTVGGKYNR
70 80 90 100 110 120
GLTVVQTFQE LVEPRKQDAE SLQRALTVGW CVELLQAFFL VLDDIMDSSY TRRGQICWYQ
130 140 150 160 170 180
KPGIGLDAIN DALLLEAAIY RLLKFYCREQ PYYLNLLELF LQSSYQTEIG QTLDLITAPQ
190 200 210 220 230 240
GQVDLGRYTE KRYKSIVKYK TAFYSFYLPI AAAMYMAGID GEKEHANALK ILLEMGEFFQ
250 260 270 280 290 300
IQDDYLDLFG DPSVTGKVGT DIQDNKCSWL VVQCLLRATP QQRQILEENY GQKDPEKVAR
310 320 330 340 350
VKALYEELDL RSVFFKYEED SYNRLKSLIE QCSAPLPPSI FLELANKIYK RRK
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P05369 in FASTA format |
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