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UniProtKB/Swiss-Prot entry P05336

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ADH1_HORVU
Primary accession number P05336
Secondary accession numbers Q40011 Q40012 Q40013 Q40014
Integrated into Swiss-Prot on November 1, 1988
Sequence was last modified on November 1, 1988 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 66)
Name and origin of the protein
Protein name Alcohol dehydrogenase 1
Synonym EC 1.1.1.1
Gene name
Name: ADH1
From
Hordeum vulgare (Barley) [TaxID: 4513] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BEP clade; Pooideae; Triticeae; Hordeum.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=cv. Himalaya;
DOI=10.1093/nar/16.14.7182; PubMed=3405765 [NCBI, ExPASy, EBI, Israel, Japan]
Good A., Pelcher L.E., Crosby W.L.;
"Nucleotide sequence of a complete barley alcohol dehydrogenase 1 cDNA.";
Nucleic Acids Res. 16:7182-7182(1988).
[2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 74-304.
STRAIN=cv. Proctor;
DOI=10.1007/BF00015667; AGRICOLA=IND92000066
Trick M., Dennis E.S., Edwards K.J.R., Peacock W.J.;
"Molecular analysis of the alcohol dehydrogenase gene family of barley.";
Plant Mol. Biol. 11:147-160(1988).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X07774; CAA30600.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X12732; CAB51640.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S01893; S01893.
UniGene Hv.22954
3D structure databases
HSSP P11766; 1M6H. [HSSP ENTRY / PDB]
ModBase P05336.
Organism-specific databases
Gramene P05336; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0004022; Molecular function: alcohol dehydrogenase activity (inferred from electronic annotation from EC).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR013154; AlcDHase_GroES-like.
IPR002085; AlcDHase_SF_Zn.
IPR013149; AlcDHase_Zn-bd.
IPR002328; AlcDHase_Zn_CS.
Graphical view of domain structure.
PANTHER PTHR11695; ADH_Sf_Zn; 1.
Pfam PF08240; ADH_N; 1.
PF00107; ADH_zinc_N; 1.
Pfam graphical view of domain structure.
PROSITE PS00059; ADH_ZINC; 1.
BLOCKS P05336.
ProtoNet P05336.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   379  379     Alcohol dehydrogenase 1. PRO_0000160699
METAL   47    47        Zinc 1; catalytic (By similarity). 
METAL   69    69        Zinc 1; catalytic (By similarity). 
METAL   99    99        Zinc 2 (By similarity). 
METAL   102   102        Zinc 2 (By similarity). 
METAL   105   105        Zinc 2 (By similarity). 
METAL   113   113        Zinc 2 (By similarity). 
METAL   177   177        Zinc 1; catalytic (By similarity). 
CONFLICT   74    74        I -> T (in Ref. 2; CAB51640). 
CONFLICT   93    93        P -> A (in Ref. 2; CAB51640). 
CONFLICT   126   127        IG -> NR (in Ref. 2; CAB51640). 
CONFLICT   134   134        S -> F (in Ref. 2; CAB51640). 
CONFLICT   205   205        A -> S (in Ref. 2; CAB51640). 
CONFLICT   210   210        A -> T (in Ref. 2; CAB51640). 
CONFLICT   225   225        V -> I (in Ref. 2; CAB51640). 
CONFLICT   230   230        V -> F (in Ref. 2; CAB51640). 
CONFLICT   248   248        D -> A (in Ref. 2; CAB51640). 
Sequence information
Length: 379 AA [This is the length of the unprocessed precursor] Molecular weight: 40884 Da [This is the MW of the unprocessed precursor] CRC64: 3A94ABDD2967FCB7 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MATAGKVIKC KAAVAWEAGK PLTMEEVEVA PPQAMEVRVK ILFTSLCHTD VYFWEAKGQI 

        70         80         90        100        110        120 
PMFPRIFGHE AGGIVESVGE GVTDVAPGDH VLPVFTGECK ECPHCKSAES NMCDLLRINT 

       130        140        150        160        170        180 
DRGVMIGDGK SRFSIGGKPI YHFVGTSTFS EYTVMHVGCV AKINPEAPLD KVCVLSCGIS 

       190        200        210        220        230        240 
TGLGASINVA KPPKGSTVAI FGLGAVGLAA AEGARIAGAS RIIGVDLNAV RFEEARKFGC 

       250        260        270        280        290        300 
TEFVNPKDHT KPVQQVLADM TNGGVDRSVE CTGNVNAMIQ AFECVHDGWG VAVLVGVPHK 

       310        320        330        340        350        360 
DAEFKTHPMN FLNERTLKGT FFGNFKPRTD LPNVVEMYMK KELEVEKFIT HSVPFSEINT 

       370 
AFDLMAKGEG IRCIIRMDN
P05336 in FASTA format

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