[1]
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NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
DOI=10.1038/324073a0; PubMed=3491322 [NCBI, ExPASy, EBI, Israel, Japan]
Hirano T.,
Yasukawa K.,
Harada H.,
Taga T.,
Watanabe Y.,
Matsuda T.,
Kashiwamura S.,
Nakajima K.,
Koyama K.,
Iwamatsu A.,
Tsunasawa S.,
Sakiyama F.,
Matsui H.,
Takahara Y.,
Taniguchi T.,
Kishimoto T.;
"Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin.";
Nature 324:73-76(1986).
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[2]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=3500852 [NCBI, ExPASy, EBI, Israel, Japan]
Yasukawa K.,
Hirano T.,
Watanabe Y.,
Muratani K.,
Matsuda T.,
Nakai S.,
Kishimoto T.;
"Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene.";
EMBO J. 6:2939-2945(1987).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3538015 [NCBI, ExPASy, EBI, Israel, Japan]
May L.T.,
Helfgott D.C.,
Sehgal P.B.;
"Anti-beta-interferon antibodies inhibit the increased expression of HLA-B7 mRNA in tumor necrosis factor-treated human fibroblasts: structural studies of the beta 2 interferon involved.";
Proc. Natl. Acad. Sci. U.S.A. 83:8957-8961(1986).
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[4]
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NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3023045 [NCBI, ExPASy, EBI, Israel, Japan]
Zilberstein A.,
Ruggieri R.,
Korn J.H.,
Revel M.;
"Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines.";
EMBO J. 5:2529-2537(1986).
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[5]
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NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3320204 [NCBI, ExPASy, EBI, Israel, Japan]
Brakenhoff J.P.J.,
de Groot E.R.,
Evers R.F.,
Pannekoek H.,
Aarden L.A.;
"Molecular cloning and expression of hybridoma growth factor in Escherichia coli.";
J. Immunol. 139:4116-4121(1987).
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[6]
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NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/0006-291X(89)92328-0; PubMed=2789513 [NCBI, ExPASy, EBI, Israel, Japan]
Tonouchi N.,
Miwa K.,
Karasuyama H.,
Matsui H.;
"Deletion of 3' untranslated region of human BSF-2 mRNA causes stabilization of the mRNA and high-level expression in mouse NIH3T3 cells.";
Biochem. Biophys. Res. Commun. 163:1056-1062(1989).
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[7]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
TISSUE=Fibroblast;
PubMed=3758081 [NCBI, ExPASy, EBI, Israel, Japan]
Haegeman G.,
Content J.,
Volckaert G.,
Derynck R.,
Tavernier J.,
Fiers W.;
"Structural analysis of the sequence coding for an inducible 26-kDa protein in human fibroblasts.";
Eur. J. Biochem. 159:625-632(1986).
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[8]
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NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3266463 [NCBI, ExPASy, EBI, Israel, Japan]
Wong G.,
Witek-Giannotti J.,
Hewick R.,
Clark S.,
Ogawa M.;
"Interleukin 6: identification as a hematopoietic colony-stimulating factor.";
Behring Inst. Mitt. 83:40-47(1988).
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[9]
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NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1291290 [NCBI, ExPASy, EBI, Israel, Japan]
Chen Q.Y.;
"Stable and efficient expression of human interleukin-6 cDNA in mammalian cells after gene transfer.";
Zhonghua Zhong Liu Za Zhi 14:340-344(1992).
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[10]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS SER-32 AND VAL-162.
SeattleSNPs program for genomic applications;
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
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[11]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[12]
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PROTEIN SEQUENCE OF 30-63.
PubMed=3279116 [NCBI, ExPASy, EBI, Israel, Japan]
van Damme J.,
van Beeumen J.,
Decock B.,
van Snick J.,
de Ley M.,
Billiau A.;
"Separation and comparison of two monokines with lymphocyte-activating factor activity: IL-1 beta and hybridoma growth factor (HGF). Identification of leukocyte-derived HGF as IL-6.";
J. Immunol. 140:1534-1541(1988).
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[13]
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PROTEIN SEQUENCE OF 30-50.
PubMed=2610854 [NCBI, ExPASy, EBI, Israel, Japan]
Ming J.E.,
Cernetti C.,
Steinman R.M.,
Granelli-Piperno A.;
"Interleukin 6 is the principal cytolytic T lymphocyte differentiation factor for thymocytes in human leukocyte conditioned medium.";
J. Mol. Cell. Immunol. 4:203-211(1989).
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[14]
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PROTEIN SEQUENCE OF 30-40, AND GLYCOSYLATION.
DOI=10.1016/1043-4666(91)90018-9; PubMed=1883960 [NCBI, ExPASy, EBI, Israel, Japan]
May L.T.,
Shaw J.E.,
Khanna A.K.,
Zabriskie J.B.,
Sehgal P.B.;
"Marked cell-type-specific differences in glycosylation of human interleukin-6.";
Cytokine 3:204-211(1991).
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[15]
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PROTEIN SEQUENCE OF 50-212 OF RECOMBINANT FORM LACKING FIRST DISULFIDE BOND.
PubMed=7851440 [NCBI, ExPASy, EBI, Israel, Japan]
Breton J.,
la Fiura A.,
Bertolero F.,
Orsini G.,
Valsasina B.,
Ziliotto R.,
de Filippis V.,
Polverino de Laureto P.,
Fontana A.;
"Structure, stability and biological properties of a N-terminally truncated form of recombinant human interleukin-6 containing a single disulfide bond.";
Eur. J. Biochem. 227:573-581(1995).
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[16]
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DISULFIDE BONDS.
DOI=10.1016/0003-9861(89)90205-1; PubMed=2472117 [NCBI, ExPASy, EBI, Israel, Japan]
Clogston C.L.,
Boone T.C.,
Crandall B.C.,
Mendiaz E.A.,
Lu H.S.;
"Disulfide structures of human interleukin-6 are similar to those of human granulocyte colony stimulating factor.";
Arch. Biochem. Biophys. 272:144-151(1989).
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[17]
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MUTAGENESIS.
DOI=10.1016/0014-5793(91)80491-K; PubMed=2037043 [NCBI, ExPASy, EBI, Israel, Japan]
Luetticken C.,
Kruettgen A.,
Moeller C.,
Heinrich P.C.,
Rose-John S.;
"Evidence for the importance of a positive charge and an alpha-helical structure of the C-terminus for biological activity of human IL-6.";
FEBS Lett. 282:265-267(1991).
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[18]
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STRUCTURE BY NMR.
DOI=10.1021/bi951949e; PubMed=8555185 [NCBI, ExPASy, EBI, Israel, Japan]
Nishimura C.,
Watanabe A.,
Gouda H.,
Shimada I.,
Arata Y.;
"Folding topologies of human interleukin-6 and its mutants as studied by NMR spectroscopy.";
Biochemistry 35:273-281(1996).
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[19]
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STRUCTURE BY NMR.
DOI=10.1006/jmbi.1997.0933; PubMed=9159484 [NCBI, ExPASy, EBI, Israel, Japan]
Xu G.-Y.,
Yu H.-A.,
Hong J.,
Stahl M.,
McDonagh T.,
Kay L.E.,
Cumming D.A.;
"Solution structure of recombinant human interleukin-6.";
J. Mol. Biol. 268:468-481(1997).
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[20]
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X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).
DOI=10.1093/emboj/16.5.989; PubMed=9118960 [NCBI, ExPASy, EBI, Israel, Japan]
Somers W.,
Stahl M.,
Seehra J.S.;
"1.9-A crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling.";
EMBO J. 16:989-997(1997).
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[21]
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INVOLVEMENT IN SUSCEPTIBILITY TO SYSTEMIC JUVENILE RHEUMATOID ARTHRITIS.
PubMed=9769329 [NCBI, ExPASy, EBI, Israel, Japan]
Fishman D.,
Faulds G.,
Jeffery R.,
Mohamed-Ali V.,
Yudkin J.S.,
Humphries S.,
Woo P.;
"The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis.";
J. Clin. Invest. 102:1369-1376(1998).
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[22]
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INVOLVEMENT IN SUSCEPTIBILITY TO KAPOSI SARCOMA.
PubMed=11001912 [NCBI, ExPASy, EBI, Israel, Japan]
Foster C.B.,
Lehrnbecher T.,
Samuels S.,
Stein S.,
Mol F.,
Metcalf J.A.,
Wyvill K.,
Steinberg S.M.,
Kovacs J.,
Blauvelt A.,
Yarchoan R.,
Chanock S.J.;
"An IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in men infected with human immunodeficiency virus.";
Blood 96:2562-2567(2000).
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[23]
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INVOLVEMENT IN BMD.
DOI=10.1007/s100380170077; PubMed=11355017 [NCBI, ExPASy, EBI, Israel, Japan]
Ota N.,
Nakajima T.,
Nakazawa I.,
Suzuki T.,
Hosoi T.,
Orimo H.,
Inoue S.,
Shirai Y.,
Emi M.;
"A nucleotide variant in the promoter region of the interleukin-6 gene associated with decreased bone mineral density.";
J. Hum. Genet. 46:267-272(2001).
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[24]
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INVOLVEMENT IN BMD.
DOI=10.1007/s10038-003-0020-8; PubMed=12768442 [NCBI, ExPASy, EBI, Israel, Japan]
Chung H.W.,
Seo J.-S.,
Hur S.E.,
Kim H.L.,
Kim J.Y.,
Jung J.H.,
Kim L.H.,
Park B.L.,
Shin H.D.;
"Association of interleukin-6 promoter variant with bone mineral density in pre-menopausal women.";
J. Hum. Genet. 48:243-248(2003).
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