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UniProtKB/Swiss-Prot entry P05208

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ELA2A_MOUSE
Primary accession number P05208
Secondary accession numbers None
Integrated into Swiss-Prot on August 13, 1987
Sequence was last modified on August 13, 1987 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 79)
Name and origin of the protein
Protein name Elastase-2A [Precursor]
Synonyms EC 3.4.21.71
Elastase-2
Gene name
Name: Ela2a
Synonyms: Ela-2, Ela2
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
DOI=10.1093/nar/14.21.8307; PubMed=3641189 [NCBI, ExPASy, EBI, Israel, Japan]
Stevenson B.J., Hagenbuechle O., Wellauer P.K.;
"Sequence organisation and transcriptional regulation of the mouse elastase II and trypsin genes.";
Nucleic Acids Res. 14:8307-8330(1986).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N;
TISSUE=Colon;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X04573; CAA28242.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X04576; CAA28244.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC026552; AAH26552.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A25528; A25528.
RefSeq NP_031945.1; -.
UniGene Mm.45316
3D structure databases
HSSP P08419; 1BRU. [HSSP ENTRY / PDB]
SMR P05208; 31-271.
ModBase P05208.
Protein family/group databases
MEROPS S01.155; -.
Organism-specific databases
MGI MGI:95316; Ela2a.
Gene expression databases
ArrayExpress P05208; -.
CleanEx MM_ELA2; -.
GermOnline ENSMUSG00000058579; Mus musculus.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001254; Peptidase_S1_S6.
IPR001314; Peptidase_S1A.
Graphical view of domain structure.
Pfam PF00089; Trypsin; 1.
Pfam graphical view of domain structure.
PRINTS PR00722; CHYMOTRYPSIN.
SMART SM00020; Tryp_SPc; 1.
SMART graphical view of domain structure.
PROSITE PS50240; TRYPSIN_DOM; 1.
PS00134; TRYPSIN_HIS; 1.
PS00135; TRYPSIN_SER; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P05208.
ProtoNet P05208.
Genome annotation databases
Ensembl ENSMUSG00000058579; Mus musculus. [Contig view]
GeneID 13706; -.
KEGG mmu:13706; -.
Phylogenomic databases
HOGENOM P05208; -.
HOVERGEN P05208; -.
Other
NextBio 284464; -.
SOURCE Ela2a; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Hydrolase; Protease; Secreted; Serine protease; Signal; Zymogen.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    16  16      
PROPEP   17    30  14     Activation peptide. PRO_0000027687
CHAIN   31   271  241     Elastase-2A. PRO_0000027688
DOMAIN   31   269  239     Peptidase S1. 
ACT_SITE   75    75        Charge relay system (By similarity). 
ACT_SITE   123   123        Charge relay system (By similarity). 
ACT_SITE   218   218        Charge relay system (By similarity). 
DISULFID   60    76        By similarity. 
DISULFID   157   224        By similarity. 
DISULFID   188   204        By similarity. 
DISULFID   214   245        By similarity. 
Sequence information
Length: 271 AA [This is the length of the unprocessed precursor] Molecular weight: 28914 Da [This is the MW of the unprocessed precursor] CRC64: FA542AE38FED3B4B [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MIRTLLLSAL VAGALSCGYP TYEVEDDVSR VVGGQEATPN TWPWQVSLQV LSSGRWRHNC 

        70         80         90        100        110        120 
GGSLVANNWV LTAAHCLSNY QTYRVLLGAH SLSNPGAGSA AVQVSKLVVH QRWNSQNVGN 

       130        140        150        160        170        180 
GYDIALIKLA SPVTLSKNIQ TACLPPAGTI LPRNYVCYVT GWGLLQTNGN SPDTLRQGRL 

       190        200        210        220        230        240 
LVVDYATCSS ASWWGSSVKS SMVCAGGDGV TSSCNGDSGG PLNCRASNGQ WQVHGIVSFG 

       250        260        270 
SSLGCNYPRK PSVFTRVSNY IDWINSVMAR N
P05208 in FASTA format

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