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UniProtKB/Swiss-Prot entry P05130


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name KPC1_DROME
Primary accession number P05130
Secondary accession numbers Q9V7V6 Q9V7V7
Integrated into Swiss-Prot on August 13, 1987
Sequence was last modified on November 28, 2002 (Sequence version 2)
Annotations were last modified on    November 4, 2008 (Entry version 100)
Name and origin of the protein
Protein name Protein kinase C, brain isozyme
Synonyms PKC
EC 2.7.11.13
dPKC53E(BR)
Gene name
Name: Pkc53E
Synonyms: PKC1
ORFNames: CG6622
From
Drosophila melanogaster (Fruit fly) [TaxID: 7227] 
Taxonomy Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM SHORT).
STRAIN=Canton-S, and Oregon-R;
PubMed=3107983 [NCBI, ExPASy, EBI, Israel, Japan]
Rosenthal A., Rhee L., Yadegari R., Paro R., Ullrich A., Goeddel D.V.;
"Structure and nucleotide sequence of a Drosophila melanogaster protein kinase C gene.";
EMBO J. 6:433-441(1987).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
DOI=10.1126/science.287.5461.2185; PubMed=10731132 [NCBI, ExPASy, EBI, Israel, Japan]
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[3]
GENOME REANNOTATION.
PubMed=12537572 [NCBI, ExPASy, EBI, Israel, Japan]
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
STRAIN=Berkeley;
TISSUE=Ovary;
Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A., Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., Miranda A., Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., Patel S., Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E.;
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X05076; CAA28736.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X05279; CAA28890.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X05280; CAA28890.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X05281; CAA28890.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X05282; CAA28890.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X05283; CAA28890.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE013599; AAF57932.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE013599; AAF57933.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY095003; AAM11331.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A32545; A32545.
RefSeq NP_476682.1; -.
NP_725626.1; -.
UniGene Dm.3632
3D structure databases
HSSP P05696; 1DSY. [HSSP ENTRY / PDB]
ModBase P05130.
Protein-protein interaction databases
IntAct P05130; -.
Enzyme and pathway databases
BioCyc DMEL-XXX-02:DMEL-XXX-02-005054-MON; -.
Organism-specific databases
FlyBase FBgn0003091; Pkc53E.
Gene expression databases
ArrayExpress P05130; -.
GermOnline CG6622; Drosophila melanogaster.
Ontologies
GO
GO:0004674; Molecular function: protein serine/threonine kinase activity (inferred from direct assay from FlyBase).
GO:0006468; Biological process: protein amino acid phosphorylation (inferred from direct assay from FlyBase).
QuickGo view.
Family and domain databases
InterPro IPR000008; C2_Ca-dep.
IPR002219; DAG_PE_bd.
IPR015745; PKC.
IPR000961; Pkinase_C.
IPR014375; Prot_kin_PKC_alpha.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR017442; Se/Thr_pkinase-rel.
IPR008271; Ser_thr_pkin_AS.
IPR002290; Ser_thr_pkinase.
Graphical view of domain structure.
PANTHER PTHR22985:SF86; PKC; 1.
Pfam PF00130; C1_1; 2.
PF00168; C2; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000550; PKC_alpha; 1.
PRINTS PR00360; C2DOMAIN.
PR00008; DAGPEDOMAIN.
ProDom PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00109; C1; 2.
SM00239; C2; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
SMART graphical view of domain structure.
PROSITE PS51285; AGC_KINASE_CTER; 1.
PS50004; C2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 1.
PS50081; ZF_DAG_PE_2; 2.
PROSITE graphical view of domain structure (profiles).
BLOCKS P05130.
ProtoNet P05130.
Genome annotation databases
Ensembl CG6622; Drosophila melanogaster. [Contig view]
GeneID 48311; -.
Phylogenomic databases
HOGENOM P05130; -.
Other
NextBio 839293; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; ATP-binding; Calcium; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Phorbol-ester binding; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   679  679     Protein kinase C, brain isozyme. PRO_0000055730
DOMAIN   191   278  88     C2. 
DOMAIN   350   608  259     Protein kinase. 
DOMAIN   609   679  71     AGC-kinase C-terminal. 
ZN_FING   45   104  60     Phorbol-ester/DAG-type 1. 
ZN_FING   119   169  51     Phorbol-ester/DAG-type 2. 
NP_BIND   356   364  9     ATP (By similarity). 
ACT_SITE   474   474        Proton acceptor (By similarity). 
BINDING   379   379        ATP (By similarity). 
VAR_SEQ   67    77        CGYQSGYAWMG -> WG (in isoform Short). VSP_004743
VARIANT   437   437  1     M -> I. 
CONFLICT   608   608        F -> S (in Ref. 1; CAA28736/CAA28890). 
CONFLICT   634   648        DVSNFDKQFTSEKTD -> MCPTLTSSSHQRKQT (in Ref. 1). 
CONFLICT   649   679        Missing (in Ref. 1). 
Sequence information
Length: 679 AA [This is the length of the unprocessed precursor] Molecular weight: 77695 Da [This is the MW of the unprocessed precursor] CRC64: 3C69AD351E36B7DC [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSEGSDNNGD PQQQGAEGEA VGENKMKSRL RKGALKKKNV FNVKDHCFIA RFFKQPTFCS 

        70         80         90        100        110        120 
HCKDFICGYQ SGYAWMGFGK QGFQCQVCSY VVHKRCHEYV TFICPGKDKG IDSDSPKTQH 

       130        140        150        160        170        180 
NFEPFTYAGP TFCDHCGSLL YGIYHQGLKC SACDMNVHAR CKENVPSLCG CDHTERRGRI 

       190        200        210        220        230        240 
YLEINVKENL LTVQIKEGRN LIPMDPNGLS DPYVKVKLIP DDKDQSKKKT RTIKACLNPV 

       250        260        270        280        290        300 
WNETLTYDLK PEDKDRRILI EVWDWDRTSR NDFMGALSFG ISEIIKNPTN GWFKLLTQDE 

       310        320        330        340        350        360 
GEYYNVPCAD DEQDLLKLKQ KPSQKKPMVM RSDTNTHTSS KKDMIRATDF NFIKVLGKGS 

       370        380        390        400        410        420 
FGKVLLAERK GSEELYAIKI LKKDVIIQDD DVECTMIEKR VLALGEKPPF LVQLHSCFQT 

       430        440        450        460        470        480 
MDRLFFVMEY VNGGDLMFQI QQFGKFKEPV AVFYAAEIAA GLFFLHTKGI LYRDLKLDNV 

       490        500        510        520        530        540 
LLDADGHVKI ADFGMCKENI VGDKTTKTFC GTPDYIAPEI ILYQPYGKSV DWWAYGVLLY 

       550        560        570        580        590        600 
EMLVGQPPFD GEDEEELFAA ITDHNVSYPK SLSKEAKEAC KGFLTKQPNK RLGCGSSGEE 

       610        620        630        640        650        660 
DVRLHPFFRR IDWEKIENRE VQPPFKPKIK HRKDVSNFDK QFTSEKTDLT PTDKVFMMNL 

       670 
DQSEFVGFSY MNPEYVFSP 

P05130 in FASTA format

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