[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BB-CK).
DOI=10.1093/nar/14.3.1449; PubMed=3513124 [NCBI, ExPASy, EBI, Israel, Japan]
Hossle J.P.,
Rosenberg U.B.,
Schaefer B.W.,
Eppenberger H.M.,
Perriard J.-C.;
"The primary structure of chicken B-creatine kinase and evidence for heterogeneity of its mRNA.";
Nucleic Acids Res. 14:1449-1463(1986).
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[2]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS BA-CK AND BB-CK-1).
STRAIN=White leghorn;
TISSUE=Brain;
PubMed=2365692 [NCBI, ExPASy, EBI, Israel, Japan]
Wirz T.,
Braendle U.,
Soldati T.,
Hossle J.P.,
Perriard J.-C.;
"A unique chicken B-creatine kinase gene gives rise to two B-creatine kinase isoproteins with distinct N termini by alternative splicing.";
J. Biol. Chem. 265:11656-11666(1990).
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[3]
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NUCLEOTIDE SEQUENCE OF 317-381.
TISSUE=Brain;
DOI=10.1016/0012-1606(85)90121-6; PubMed=3840441 [NCBI, ExPASy, EBI, Israel, Japan]
Kwiatkowski R.W.,
Ehrismann R.,
Schweinfest C.W.,
Dottin R.P.;
"Accumulation of creatine kinase mRNA during myogenesis: molecular cloning of a B-creatine kinase cDNA.";
Dev. Biol. 112:84-88(1985).
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[4]
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PROTEIN SEQUENCE OF 2-9; 12-20; 266-277 AND 320-329, AND AUTOPHOSPHORYLATION.
DOI=10.1016/0167-4838(95)00083-7; PubMed=7669815 [NCBI, ExPASy, EBI, Israel, Japan]
Hemmer W.,
Furter-Graves E.M.,
Frank G.,
Wallimann T.,
Furter R.;
"Autophosphorylation of creatine kinase: characterization and identification of a specifically phosphorylated peptide.";
Biochim. Biophys. Acta 1251:81-90(1995).
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[5]
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ALTERNATIVE SPLICING (ISOFORMS BA-CK-2; BA-CK-3 AND BA-CK-4), AND PHOSPHORYLATION.
PubMed=2307674 [NCBI, ExPASy, EBI, Israel, Japan]
Soldati T.,
Schaefer B.W.,
Perriard J.-C.;
"Alternative ribosomal initiation gives rise to chicken brain-type creatine kinase isoproteins with heterogeneous amino termini.";
J. Biol. Chem. 265:4498-4506(1990).
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[6]
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X-RAY CRYSTALLOGRAPHY (1.41 ANGSTROMS).
PubMed=10595529 [NCBI, ExPASy, EBI, Israel, Japan]
Eder M.,
Schlattner U.,
Becker A.,
Wallimann T.,
Kabsch W.,
Fritz-Wolf K.;
"Crystal structure of brain-type creatine kinase at 1.41-A resolution.";
Protein Sci. 8:2258-2269(1999).
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- FUNCTION: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
- CATALYTIC ACTIVITY: ATP + creatine = ADP + phosphocreatine.
- SUBUNIT: Dimer of identical or non-identical chains. With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain.
- SUBCELLULAR LOCATION: Cytoplasm.
- ALTERNATIVE PRODUCTS:
5 named isoforms [FASTA] produced by alternative splicing.
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| Name | Ba-CK |
| Isoform ID | P05122-2 |
| Features which should be applied to build the isoform sequence: VSP_002814. |
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| Name | Bb-CK-2 |
| Isoform ID | P05122-3 |
| Features which should be applied to build the isoform sequence: VSP_010768. |
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| Name | Bb-CK-3 |
| Isoform ID | P05122-4 |
| Features which should be applied to build the isoform sequence: VSP_010769. |
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| Name | Bb-CK-4 |
| Isoform ID | P05122-5 |
| Features which should be applied to build the isoform sequence: VSP_010770. |
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- TISSUE SPECIFICITY: Expressed in almost all tissues and found enriched in various region of the brain, retina heart, gizzard, gut and sperm.
- PTM: Ba-CK and Bb-CK are phosphorylated.
- PTM: The N-terminus of BA-CK is blocked.
- SIMILARITY: Belongs to the ATP:guanido phosphotransferase family.
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