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UniProtKB/Swiss-Prot entry P05109


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name S10A8_HUMAN
Primary accession number P05109
Secondary accession numbers A8K5L3 Q5SY70 Q9UC84 Q9UC92 Q9UCJ0 Q9UCM6
Integrated into Swiss-Prot on August 13, 1987
Sequence was last modified on January 1, 1988 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 108)
Name and origin of the protein
Protein name Protein S100-A8
Synonyms S100 calcium-binding protein A8
Calgranulin-A
Migration inhibitory factor-related protein 8
MRP-8
P8
Cystic fibrosis antigen
CFAG
Leukocyte L1 complex light chain
Calprotectin L1L subunit
Urinary stone protein band A
Gene name
Name: S100A8
Synonyms: CAGA, CFAG, MRP8
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1038/326614a0; PubMed=3561500 [NCBI, ExPASy, EBI, Israel, Japan]
Dorin J.R., Novak M., Hill R.E., Brock D.J.H., Secher D.S., van Heyningen V.;
"A clue to the basic defect in cystic fibrosis from cloning the CF antigen gene.";
Nature 326:614-617(1987).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1038/330080a0; PubMed=3313057 [NCBI, ExPASy, EBI, Israel, Japan]
Odink K., Cerletti N., Bruggen J., Clerc R.G., Tarcsay L., Zwaldo G., Gerhards G., Schlegel R., Sorg C.;
"Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis.";
Nature 330:80-82(1987).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=3405210 [NCBI, ExPASy, EBI, Israel, Japan]
Lagasse E., Clerc R.G.;
"Cloning and expression of two human genes encoding calcium-binding proteins that are regulated during myeloid differentiation.";
Mol. Cell. Biol. 8:2402-2410(1988).
[4]
NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 1-30.
PubMed=2039599 [NCBI, ExPASy, EBI, Israel, Japan]
Schaefer T., Sachse G.E., Gassen H.G.;
"The calcium-binding protein MRP-8 is produced by human pulmonary tumor cells.";
Biol. Chem. Hoppe-Seyler 372:1-4(1991).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Tongue;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).";
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04727; PubMed=16710414 [NCBI, ExPASy, EBI, Israel, Japan]
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[9]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[10]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Skeletal muscle;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[11]
PROTEIN SEQUENCE OF 1-19; 24-35 AND 63-89.
DOI=10.1006/bbrc.1996.0616; PubMed=8619876 [NCBI, ExPASy, EBI, Israel, Japan]
Marti T., Erttmann K.D., Gallin M.Y.;
"Host-parasite interaction in human onchocerciasis: identification and sequence analysis of a novel human calgranulin.";
Biochem. Biophys. Res. Commun. 221:454-458(1996).
[12]
PROTEIN SEQUENCE OF 1-27.
PubMed=8423249 [NCBI, ExPASy, EBI, Israel, Japan]
Miyasaki K.T., Bodeau A.L., Murthy A.R., Lehrer R.I.;
"In vitro antimicrobial activity of the human neutrophil cytosolic S-100 protein complex, calprotectin, against Capnocytophaga sputigena.";
J. Dent. Res. 72:517-523(1993).
[13]
PROTEIN SEQUENCE OF 1-25.
TISSUE=Neutrophil;
PubMed=1326551 [NCBI, ExPASy, EBI, Israel, Japan]
Lemarchand P., Vaglio M., Mauel J., Markert M.;
"Translocation of a small cytosolic calcium-binding protein (MRP-8) to plasma membrane correlates with human neutrophil activation.";
J. Biol. Chem. 267:19379-19382(1992).
[14]
PROTEIN SEQUENCE OF 1-20.
PubMed=7849642 [NCBI, ExPASy, EBI, Israel, Japan]
Umekawa T., Kurita T.;
"Calprotectin-like protein is related to soluble organic matrix in calcium oxalate urinary stone.";
Biochem. Mol. Biol. Int. 34:309-313(1994).
[15]
PROTEIN SEQUENCE OF 1-20.
TISSUE=Ascites;
PubMed=7695842 [NCBI, ExPASy, EBI, Israel, Japan]
Nakai M., Ishikawa M., Hamada Y., Sugano S.;
"Isolation of an ascitic oncodevelopmental protein exhibiting high sequence homology with calcium-binding protein MRP8.";
Biol. Chem. Hoppe-Seyler 375:789-792(1994).
[16]
PROTEIN SEQUENCE OF 38-47 AND 50-56.
TISSUE=Keratinocyte;
DOI=10.1002/elps.11501301199; PubMed=1286667 [NCBI, ExPASy, EBI, Israel, Japan]
Rasmussen H.H., van Damme J., Puype M., Gesser B., Celis J.E., Vandekerckhove J.;
"Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.";
Electrophoresis 13:960-969(1992).
[17]
IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
Colinge J., Superti-Furga G., Bennett K.L.;
Submitted (OCT-2008) to UniProtKB.
[18]
X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).
DOI=10.1107/S0907444900002833; PubMed=10771424 [NCBI, ExPASy, EBI, Israel, Japan]
Ishikawa K., Nakagawa A., Tanaka I., Suzuki M., Nishihira J.;
"The structure of human MRP8, a member of the S100 calcium-binding protein family, by MAD phasing at 1.9 A resolution.";
Acta Crystallogr. D 56:559-566(2000).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Y00278; CAA68390.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X06234; CAA29580.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M21005; AAA36327.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK291328; BAF84017.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR407674; CAG28602.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BT007378; AAP36042.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL591704; CAI19497.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CH471121; EAW53330.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC005928; AAH05928.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00007047; -.
PIR A31848; BCHUCF.
RefSeq NP_002955.2; -.
UniGene Hs.416073
3D structure databases
PDB
1MR8; X-ray; 1.90 A; A/B=1-93.[ExPASy / RCSB / EBI]
1XK4; X-ray; 1.80 A; A/B/E/F/I/J=1-93.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 1MR8; -.
1XK4; -.
ModBase P05109.
Protein-protein interaction databases
DIP DIP:1165N; -.
IntAct P05109; 25.
2D gel databases
SWISS-2DPAGE P05109; -.
Aarhus/Ghent-2DPAGE 1003; IEF.
PMMA-2DPAGE P05109; -.
Organism-specific databases
GeneCards GC01M151629; -.
H-InvDB HIX0001079; -.
HGNC HGNC:10498; S100A8.
GenAtlas S100A8.
HPA CAB002791; -.
MIM 123885; gene. [NCBI / EBI]
PharmGKB PA34910; -.
Gene expression databases
ArrayExpress P05109; -.
Bgee P05109; -.
CleanEx HS_S100A8; -.
GermOnline ENSG00000143546; Homo sapiens.
Ontologies
GO
GO:0005509; Molecular function: calcium ion binding (traceable author statement from ProtInc).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0006954; Biological process: inflammatory response (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR011992; EF-Hand_type.
IPR018248; EF_hand.
IPR018247; EF_HAND_1.
IPR018249; EF_HAND_2.
IPR001751; S100_Ca_bd.
IPR013787; S100_Ca_bd_sub.
Graphical view of domain structure.
Gene3D G3DSA:1.10.238.10; EF-Hand_type; 1.
Pfam PF00036; efhand; 1.
PF01023; S_100; 1.
Pfam graphical view of domain structure.
ProDom PD003407; CaBP_S100; 1.
PD000012; EF-hand; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00018; EF_HAND_1; 1.
PS50222; EF_HAND_2; 1.
PS00303; S100_CABP; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PeptideAtlas P05109; -.
PRIDE P05109; -.
Genome annotation databases
Ensembl ENSG00000143546; Homo sapiens. [Contig view]
GeneID 6279; -.
KEGG hsa:6279; -.
Phylogenomic databases
HOGENOM P05109; -.
HOVERGEN P05109; -.
OMA P05109; KDADTWF.
Other
NextBio 24373; -.
SOURCE S100A8; Homo sapiens.
ProtoNet P05109.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Calcium; Direct protein sequencing; Repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom  To Length Description FTId
CHAIN   1   93  93     Protein S100-A8. PRO_0000143993
DOMAIN   12   47  36     EF-hand 1. 
DOMAIN   46   81  36     EF-hand 2. 
CA_BIND   20   33  14     1; low affinity. 
CA_BIND   59   70  12     2; high affinity. 
CONFLICT   80   93        VAAHKKSHEESHKE -> WQPTKKAMKKATKSS (in Ref. 1; CAA68390). 
HELIX   4   20  17      
STRAND   22   25  4      
HELIX   31   41  11      
HELIX   44   47  4      
HELIX   51   58  8      
STRAND   63   66  4      
HELIX   68   86  19      
Sequence information
Length: 93 AA [This is the length of the unprocessed precursor] Molecular weight: 10835 Da [This is the MW of the unprocessed precursor] CRC64: 78F589140B9CE166 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MLTELEKALN SIIDVYHKYS LIKGNFHAVY RDDLKKLLET ECPQYIRKKG ADVWFKELDI 

        70         80         90 
NTDGAVNFQE FLILVIKMGV AAHKKSHEES HKE 

P05109 in FASTA format

View entry in raw text format (no links)
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BLAST logo BLAST submission on ExPASy/SIB
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