[1]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Muscle; PubMed=2419325 [NCBI, ExPASy, EBI, Israel, Japan] Kishi F., Maruyama M., Tanizawa Y., Nakazawa A.; "Isolation and characterization of cDNA for chicken muscle adenylate kinase."; J. Biol. Chem. 261:2942-2945(1986).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. TISSUE=Muscle; PubMed=2844738 [NCBI, ExPASy, EBI, Israel, Japan] Suminami Y., Kishi F., Torigoe T., Nakazawa A.; "Structure and complete nucleotide sequence of the gene encoding chicken cytosolic adenylate kinase."; J. Biochem. 103:611-617(1988).
[3]	MUTAGENESIS OF LYS-22 AND LYS-28. DOI=10.1021/bi00470a006; PubMed=2161682 [NCBI, ExPASy, EBI, Israel, Japan] Tian G.C., Yan H.G., Jiang R.T., Kishi F., Nakazawa A., Tsai M.D.; "Mechanism of adenylate kinase. Are the essential lysines essential?"; Biochemistry 29:4296-4304(1990).

Comments

FUNCTION: This small ubiquitous enzyme is essential for maintenance and cell growth.
CATALYTIC ACTIVITY: ATP + AMP = 2 ADP.
SUBUNIT: Monomer.
SUBCELLULAR LOCATION: Cytoplasm.
SIMILARITY: Belongs to the adenylate kinase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M12153; AAB59961.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
D00251; BAA00182.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

A25327; A25327.

NP_990440.1; -.

3D structure databases

HSSP

P00571; 3ADK. [HSSP ENTRY / SWISS-3DIMAGE / PDB]

SMR

P05081; 4-194.

ModBase

P05081.

Family and domain databases

InterPro

IPR000850; Adenylate_kin.
IPR006267; Adenylate_kin1.
Graphical view of domain structure.

PANTHER

PTHR23359; Adenylate_kin; 1.

Pfam

PF00406; ADK; 1.
Pfam graphical view of domain structure.

PRINTS

PR00094; ADENYLTKNASE.

ProDom

PD000657; Adenylate_kin; 1.
[Domain structure / List of seq. sharing at least 1 domain]

TIGRFAMs

TIGR01360; aden_kin_iso1; 1.

PROSITE

PS00113; ADENYLATE_KINASE; 1.

Genome annotation databases

GeneID

396002; -.

KEGG

gga:396002; -.

Phylogenomic databases

HOVERGEN

P05081; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ATP-binding; Cytoplasm; Kinase; Nucleotide-binding; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 194`	`194`	`Adenylate kinase isoenzyme 1.`	`PRO_0000158915`
`NP_BIND`	`16 24`	`9`	`ATP (By similarity).`
`MUTAGEN`	`22 22`		`K->M: Reduced activity.`
`MUTAGEN`	`28 28`		`K->M: No loss in activity.`

Sequence information

Length: 194 AA [This is the length of the unprocessed precursor]

Molecular weight: 21683 Da [This is the MW of the unprocessed precursor]

CRC64: 7DCAEF3E1DD474EC [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSTEKLKHHK IIFVVGGPGS GKGTQCEKIV HKYGYTHLST GDLLRAEVSS GSERGKKLQA 

        70         80         90        100        110        120 
IMEKGELVPL DTVLDMLRDA MLAKADTSKG FLIDGYPREV KQGEEFEKKI APPTLLLYVD 

       130        140        150        160        170        180 
AGKETMVKRL LKRGETSGRV DDNEETIKKR LETYYKATEP VIAFYKGRGI VRQLNAEGTV 

       190 
DEVFQQVCSY LDKL

P05081 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools