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UniProtKB/Swiss-Prot entry P05060


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name SCG1_HUMAN
Primary accession number P05060
Secondary accession numbers A8K021 Q59EU9 Q6IBS6 Q9BQV6 Q9UC25 Q9UJA6
Integrated into Swiss-Prot on August 13, 1987
Sequence was last modified on August 13, 1987 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 93)
Name and origin of the protein
Protein name Secretogranin-1 [Precursor]
Synonyms Secretogranin I
SgI
Chromogranin-B
CgB
Contains GAWK peptide
CCB peptide
Gene name
Name: CHGB
Synonyms: SCG1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 21-34; 85-93; 334-340 AND 347-355, AND TISSUE SPECIFICITY.
TISSUE=Adrenal medulla;
PubMed=3608978 [NCBI, ExPASy, EBI, Israel, Japan]
Benedum U.M., Lamouroux A., Konecki D.S., Hille A., Baeuerle P.A., Frank R., Lottspeich F., Mallet J., Huttner W.B.;
"The primary structure of human secretogranin I (chromogranin B): comparison with chromogranin A reveals homologous terminal domains and a large intervening variable region.";
EMBO J. 6:1203-1211(1987).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS THR-93; GLN-178; GLY-353 AND HIS-417.
TISSUE=Adrenal gland;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS THR-93; GLN-178; GLY-353 AND HIS-417.
TISSUE=Brain;
Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.;
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT THR-243.
DOI=10.1038/414865a; PubMed=11780052 [NCBI, ExPASy, EBI, Israel, Japan]
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 20.";
Nature 414:865-871(2001).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[8]
PROTEIN SEQUENCE OF 21-48.
DOI=10.1016/0167-0115(91)90216-4; PubMed=1882087 [NCBI, ExPASy, EBI, Israel, Japan]
Gill B.M., Barbosa J.A., Dinh T.Q., Garrod S., O'Connor D.T.;
"Chromogranin B: isolation from pheochromocytoma, N-terminal sequence, tissue distribution and secretory vesicle processing.";
Regul. Pept. 33:223-235(1991).
[9]
PROTEIN SEQUENCE OF 334-385.
DOI=10.1016/0196-9781(94)00176-6; PubMed=7784254 [NCBI, ExPASy, EBI, Israel, Japan]
Woussen-Colle M.-C., Gourlet P., Vandermeers A., Vandermeers-Piret M.-C., D'Haens J., Velkeniers B., Robberecht P.;
"Identification of a new chromogranin B fragment (314-365) in endocrine tumors.";
Peptides 16:231-236(1995).
[10]
PROTEIN SEQUENCE OF 440-513.
TISSUE=Pituitary;
DOI=10.1016/0006-291X(85)90648-5; PubMed=3970711 [NCBI, ExPASy, EBI, Israel, Japan]
Benjannet S., Leduc R., Lazure C., Seidah N.G., Marcinkiewicz M., Chretien M.;
"GAWK, a novel human pituitary polypeptide: isolation, immunocytochemical localization and complete amino acid sequence.";
Biochem. Biophys. Res. Commun. 126:602-609(1985).
[11]
PROTEIN SEQUENCE OF 617-676.
TISSUE=Pituitary;
DOI=10.1016/0014-5793(87)80438-6; PubMed=3678488 [NCBI, ExPASy, EBI, Israel, Japan]
Benjannet S., Leduc R., Adrouche N., Falgueyret J.P., Marcinkiewicz M., Seidah N.G., Mbikay M., Lazure C., Chretien M.;
"Chromogranin B (secretogranin I), a putative precursor of two novel pituitary peptides through processing at paired basic residues.";
FEBS Lett. 224:142-148(1987).
[12]
PHOSPHORYLATION AT SER-149 AND SER-405.
TISSUE=Pituitary;
DOI=10.1002/pmic.200300584; PubMed=14997482 [NCBI, ExPASy, EBI, Israel, Japan]
Giorgianni F., Beranova-Giorgianni S., Desiderio D.M.;
"Identification and characterization of phosphorylated proteins in the human pituitary.";
Proteomics 4:587-598(2004).
[13]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-149; SER-182; SER-183; SER-259; SER-263; SER-311; SER-335; SER-377; SER-405; SER-617 AND SER-626, AND MASS SPECTROMETRY.
TISSUE=Pituitary;
DOI=10.1007/s11102-006-8916-x; PubMed=16807684 [NCBI, ExPASy, EBI, Israel, Japan]
Beranova-Giorgianni S., Zhao Y., Desiderio D.M., Giorgianni F.;
"Phosphoproteomic analysis of the human pituitary.";
Pituitary 9:109-120(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Y00064; CAA68271.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK289386; BAF82075.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR456726; CAG33007.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB209712; BAD92949.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL035461; CAB55272.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL035461; CAC34360.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CH471133; EAX10410.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC000375; AAH00375.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A29264; CNHUB.
RefSeq NP_001810.1; -.
UniGene Hs.516874
3D structure databases
ModBase P05060.
PTM databases
PhosphoSite P05060; -.
Organism-specific databases
H-InvDB HIX0015625; -.
HGNC HGNC:1930; CHGB.
GenAtlas CHGB.
HPA CAB009403; -.
HPA008759; -.
HPA012602; -.
MIM 118920; gene. [NCBI / EBI]
PharmGKB PA26462; -.
GeneCards P05060.
Gene expression databases
ArrayExpress P05060; -.
CleanEx HS_CHGB; -.
GermOnline ENSG00000089199; Homo sapiens.
Ontologies
GO
GO:0005179; Molecular function: hormone activity (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR001819; Chromogranin_AB.
IPR001990; Granin.
Graphical view of domain structure.
PANTHER PTHR10583; Chromogranin_AB; 1.
Pfam PF01271; Granin; 1.
Pfam graphical view of domain structure.
PRINTS PR00659; CHROMOGRANIN.
PROSITE PS00422; GRANINS_1; 1.
PS00423; GRANINS_2; 1.
BLOCKS P05060.
Proteomic databases
PeptideAtlas P05060; -.
Genome annotation databases
Ensembl ENSG00000089199; Homo sapiens. [Contig view]
GeneID 1114; -.
KEGG hsa:1114; -.
Phylogenomic databases
HOVERGEN P05060; -.
Other
SOURCE CHGB; Homo sapiens.
ProtoNet P05060.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Cleavage on pair of basic residues; Direct protein sequencing; Glycoprotein; Phosphoprotein; Polymorphism; Secreted; Signal; Sulfation.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    20  20      
CHAIN   21   677  657     Secretogranin-1. PRO_0000005438
PEPTIDE   440   513  74     GAWK peptide. PRO_0000005439
PEPTIDE   617   676  60     CCB peptide. PRO_0000005440
COMPBIAS   163   171  9     Poly-Glu. 
MOD_RES   79    79        Phosphothreonine (Probable). 
MOD_RES   99    99        Phosphoserine (Potential). 
MOD_RES   100   100        Phosphoserine (Potential). 
MOD_RES   149   149        Phosphoserine. 
MOD_RES   153   153        N6-acetyllysine (By similarity). 
MOD_RES   182   182        Phosphoserine. 
MOD_RES   183   183        Phosphoserine. 
MOD_RES   259   259        Phosphoserine. 
MOD_RES   263   263        Phosphoserine. 
MOD_RES   293   293        Phosphoserine (Potential). 
MOD_RES   294   294        Phosphoserine (Potential). 
MOD_RES   311   311        Phosphoserine. 
MOD_RES   335   335        Phosphoserine. 
MOD_RES   341   341        Sulfotyrosine (By similarity). 
MOD_RES   377   377        Phosphoserine. 
MOD_RES   380   380        Phosphoserine. 
MOD_RES   405   405        Phosphoserine (Potential). 
MOD_RES   471   471        Sulfotyrosine (Potential). 
MOD_RES   474   474        Sulfotyrosine (Probable). 
MOD_RES   533   533        Phosphoserine (Potential). 
MOD_RES   534   534        Phosphoserine (Potential). 
MOD_RES   566   566        Sulfotyrosine (Probable). 
MOD_RES   568   568        Sulfotyrosine (Potential). 
MOD_RES   617   617        Phosphoserine. 
MOD_RES   626   626        Phosphoserine. 
MOD_RES   631   631        Phosphoserine (By similarity). 
CARBOHYD   116   116        O-linked (GalNAc...) (Probable). 
DISULFID   36    57         
VARIANT   93    93  1     S -> T (in dbSNP:rs6085324 [NCBI]). VAR_043578 
VARIANT   117   117  1     K -> N (in dbSNP:rs236150 [NCBI]). VAR_024414 
VARIANT   145   145  1     D -> N (in dbSNP:rs6133278 [NCBI]). VAR_028235 
VARIANT   178   178  1     R -> Q (in dbSNP:rs910122 [NCBI]). VAR_020287 
VARIANT   200   200  1     N -> H (in dbSNP:rs881118 [NCBI]). VAR_028236 
VARIANT   232   232  1     R -> Q (in dbSNP:rs6139873 [NCBI]). VAR_028237 
VARIANT   243   243  1     A -> T (in dbSNP:rs236151 [NCBI]). VAR_024415 
VARIANT   353   353  1     A -> G (in dbSNP:rs236152 [NCBI]). VAR_024416 
VARIANT   413   413  1     P -> L (in dbSNP:rs742710 [NCBI]). VAR_028238 
VARIANT   417   417  1     R -> H (in dbSNP:rs742711 [NCBI]). VAR_022012 
CONFLICT   24    24        D -> E (in Ref. 2; BAF82075). 
Sequence information
Length: 677 AA [This is the length of the unprocessed precursor] Molecular weight: 78246 Da [This is the MW of the unprocessed precursor] CRC64: 1BD4E122B1C59B11 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MQPTLLLSLL GAVGLAAVNS MPVDNRNHNE GMVTRCIIEV LSNALSKSSA PPITPECRQV 

        70         80         90        100        110        120 
LKTSRKDVKD KETTENENTK FEVRLLRDPA DASEAHESSS RGEAGAPGEE DIQGPTKADT 

       130        140        150        160        170        180 
EKWAEGGGHS RERADEPQWS LYPSDSQVSE EVKTRHSEKS QREDEEEEEG ENYQKGERGE 

       190        200        210        220        230        240 
DSSEEKHLEE PGETQNAFLN ERKQASAIKK EELVARSETH AAGHSQEKTH SREKSSQESG 

       250        260        270        280        290        300 
EEAGSQENHP QESKGQPRSQ EESEEGEEDA TSEVDKRRTR PRHHHGRSRP DRSSQGGSLP 

       310        320        330        340        350        360 
SEEKGHPQEE SEESNVSMAS LGEKRDHHST HYRASEEEPE YGEEIKGYPG VQAPEDLEWE 

       370        380        390        400        410        420 
RYRGRGSEEY RAPRPQSEES WDEEDKRNYP SLELDKMAHG YGEESEEERG LEPGKGRHHR 

       430        440        450        460        470        480 
GRGGEPRAYF MSDTREEKRF LGEGHHRVQE NQMDKARRHP QGAWKELDRN YLNYGEEGAP 

       490        500        510        520        530        540 
GKWQQQGDLQ DTKENREEAR FQDKQYSSHH TAEKRKRLGE LFNPYYDPLQ WKSSHFERRD 

       550        560        570        580        590        600 
NMNDNFLEGE EENELTLNEK NFFPEYNYDW WEKKPFSEDV NWGYEKRNLA RVPKLDLKRQ 

       610        620        630        640        650        660 
YDRVAQLDQL LHYRKKSAEF PDFYDSEEPV STHQEAENEK DRADQTVLTE DEKKELENLA 

       670 
AMDLELQKIA EKFSQRG 

P05060 in FASTA format

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