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UniProtKB/Swiss-Prot entry P05019


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IGF1B_HUMAN
Primary accession number P05019
Secondary accession numbers None
Integrated into Swiss-Prot on August 13, 1987
Sequence was last modified on August 13, 1987 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 110)
Name and origin of the protein
Protein name Insulin-like growth factor IB [Precursor]
Synonyms IGF-IB
Somatomedin-C
Mechano growth factor
MGF
Gene name
Name: IGF1
Synonyms: IBP1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2937782 [NCBI, ExPASy, EBI, Israel, Japan]
Rotwein P., Pollock K.M., Didier D.K., Krivi G.G.;
"Organization and sequence of the human insulin-like growth factor I gene. Alternative RNA processing produces two insulin-like growth factor I precursor peptides.";
J. Biol. Chem. 261:4828-4832(1986).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3455760 [NCBI, ExPASy, EBI, Israel, Japan]
Rotwein P.;
"Two insulin-like growth factor I messenger RNAs are expressed in human liver.";
Proc. Natl. Acad. Sci. U.S.A. 83:77-81(1986).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/0014-5793(86)80156-9; PubMed=3002851 [NCBI, ExPASy, EBI, Israel, Japan]
de Pagter-Holthuizen P., van Schaik F.M.A., Verduijn G.M., van Ommen G.J.B., Bouma B.N., Jansen M., Sussenbach J.S.;
"Organization of the human genes for insulin-like growth factors I and II.";
FEBS Lett. 195:179-184(1986).
[4]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
PubMed=8495408 [NCBI, ExPASy, EBI, Israel, Japan]
Sandberg-Nordqvist A.-C., Staehlbom P.-A., Reinecke M., Collins V.P., von Holst H., Sara V.;
"Characterization of insulin-like growth factor 1 in human primary brain tumors.";
Cancer Res. 53:2475-2478(1993).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 22-50.
DOI=10.1038/310777a0; PubMed=6382022 [NCBI, ExPASy, EBI, Israel, Japan]
Dull T.J., Gray A., Hayflick J.S., Ullrich A.;
"Insulin-like growth factor II precursor gene organization in relation to insulin gene family.";
Nature 310:777-781(1984).
[6]
PROTEIN SEQUENCE OF 49-118.
PubMed=632300 [NCBI, ExPASy, EBI, Israel, Japan]
Rinderknecht E., Humbel R.E.;
"The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin.";
J. Biol. Chem. 253:2769-2776(1978).
[7]
3D-STRUCTURE MODELING.
PubMed=6189745 [NCBI, ExPASy, EBI, Israel, Japan]
Blundell T.L., Bedarkar S., Humbel R.E.;
"Tertiary structures, receptor binding, and antigenicity of insulinlike growth factors.";
Fed. Proc. 42:2592-2597(1983).
[8]
STRUCTURE BY NMR.
DOI=10.1021/bi00236a022; PubMed=2036417 [NCBI, ExPASy, EBI, Israel, Japan]
Cooke R.M., Harvey T.S., Campbell I.D.;
"Solution structure of human insulin-like growth factor 1: a nuclear magnetic resonance and restrained molecular dynamics study.";
Biochemistry 30:5484-5491(1991).
[9]
STRUCTURE BY NMR.
PubMed=1319992 [NCBI, ExPASy, EBI, Israel, Japan]
Sato A., Nishimura S., Ohkubo T., Kyogoku Y., Koyama S., Kobayashi M., Yasuda T., Kobayashi Y.;
"1H-NMR assignment and secondary structure of human insulin-like growth factor-I (IGF-I) in solution.";
J. Biochem. 111:529-536(1992).
[10]
INVOLVEMENT IN IGF1 DEFICIENCY.
DOI=10.1056/NEJM199610313351805; PubMed=8857020 [NCBI, ExPASy, EBI, Israel, Japan]
Woods K.A., Camacho-Hubner C., Savage M.O., Clark A.J.;
"Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene.";
N. Engl. J. Med. 335:1363-1367(1996).
[11]
DISULFIDE BONDS.
PubMed=3242681 [NCBI, ExPASy, EBI, Israel, Japan]
Raschdorf F., Dahinden R., Maerki W., Richter W.J., Merryweather J.P.;
"Location of disulphide bonds in human insulin-like growth factors (IGFs) synthesized by recombinant DNA technology.";
Biomed. Environ. Mass Spectrom. 16:3-8(1988).
[12]
VARIANT ASP-187.
DOI=10.1038/10290; PubMed=10391209 [NCBI, ExPASy, EBI, Israel, Japan]
Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.;
"Characterization of single-nucleotide polymorphisms in coding regions of human genes.";
Nat. Genet. 22:231-238(1999).
[13]
ERRATUM.
Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.;
Nat. Genet. 23:373-373(1999).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M14155; AAA52537.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M12659; AAA52537.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M14153; AAA52537.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M14154; AAA52537.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M11568; AAA52539.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X56774; CAA40093.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X03563; CAA27250.1; ALT_SEQ; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X03420; CAA27152.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X03421; CAA27153.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X03422; CAA27154.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A01611; IGHU1B.
RefSeq NP_001104755.1; -.
UniGene Hs.160562
3D structure databases
PDB
1BQT; NMR; -; A=49-118.[ExPASy / RCSB / EBI]
1GF1; Model; -; A=49-118.[ExPASy / RCSB / EBI]
1PMX; NMR; -; A=49-118.[ExPASy / RCSB / EBI]
1WQJ; X-ray; 1.60 A; I=49-118.[ExPASy / RCSB / EBI]
2DSP; X-ray; 2.50 A; I=49-118.[ExPASy / RCSB / EBI]
2DSQ; X-ray; 2.80 A; C/I=49-118.[ExPASy / RCSB / EBI]
2DSR; X-ray; 2.10 A; I=49-118.[ExPASy / RCSB / EBI]
3LRI; NMR; -; A=49-118.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 1BQT; -.
1GF1; -.
1PMX; -.
1WQJ; -.
2DSP; -.
2DSQ; -.
2DSR; -.
3LRI; -.
ModBase P05019.
Enzyme and pathway databases
Reactome REACT_604; Hemostasis.
Organism-specific databases
HGNC HGNC:5464; IGF1.
GenAtlas IGF1.
MIM 147440; gene. [NCBI / EBI]
608747; phenotype. [NCBI / EBI]
Orphanet 73272; Growth delay due to insulin-like growth factor I deficiency.
633; Short stature due to growth hormone resistance.
PharmGKB PA29697; -.
GeneCards P05019.
Gene expression databases
ArrayExpress P05019; -.
CleanEx HS_IGF1; -.
GermOnline ENSG00000017427; Homo sapiens.
Ontologies
GO
GO:0016942; Cellular component: insulin-like growth factor binding protein complex (inferred by curator from UniProtKB).
GO:0031093; Cellular component: platelet alpha granule lumen (inferred from experiment from Reactome).
GO:0005179; Molecular function: hormone activity (inferred from direct assay from UniProtKB).
GO:0005158; Molecular function: insulin receptor binding (inferred from physical interaction from UniProtKB).
GO:0005159; Molecular function: insulin-like growth factor receptor binding (inferred from physical interaction from UniProtKB).
GO:0006916; Biological process: anti-apoptosis (inferred from direct assay from UniProtKB).
GO:0014896; Biological process: muscle hypertrophy (inferred from mutant phenotype from UniProtKB).
GO:0045445; Biological process: myoblast differentiation (inferred from direct assay from UniProtKB).
GO:0051450; Biological process: myoblast proliferation (inferred from direct assay from UniProtKB).
GO:0014904; Biological process: myotube cell development (inferred from direct assay from UniProtKB).
GO:0034392; Biological process: negative regulation of smooth muscle cell apoptosis (inferred from direct assay from UniProtKB).
GO:0014065; Biological process: phosphoinositide 3-kinase cascade (inferred from direct assay from UniProtKB).
GO:0048015; Biological process: phosphoinositide-mediated signaling (inferred from direct assay from UniProtKB).
GO:0045740; Biological process: positive regulation of DNA replication (inferred from direct assay from UniProtKB).
GO:0050679; Biological process: positive regulation of epithelial cell proliferation (inferred from direct assay from UniProtKB).
GO:0048146; Biological process: positive regulation of fibroblast proliferation (inferred from direct assay from UniProtKB).
GO:0043193; Biological process: positive regulation of gene-specific transcription (inferred from direct assay from UniProtKB).
GO:0045821; Biological process: positive regulation of glycolysis (inferred from direct assay from UniProtKB).
GO:0043568; Biological process: positive regulation of insulin-like growth factor receptor signaling pathway (inferred from direct assay from UniProtKB).
GO:0045840; Biological process: positive regulation of mitosis (inferred from direct assay from UniProtKB).
GO:0046579; Biological process: positive regulation of Ras protein signal transduction (inferred from direct assay from UniProtKB).
GO:0014911; Biological process: positive regulation of smooth muscle cell migration (inferred from direct assay from UniProtKB).
GO:0048661; Biological process: positive regulation of smooth muscle cell proliferation (inferred from direct assay from UniProtKB).
GO:0042523; Biological process: positive regulation of tyrosine phosphorylation of Stat5 protein (inferred from direct assay from UniProtKB).
GO:0014834; Biological process: satellite cell maintenance involved in skeletal muscle regeneration (inferred from direct assay from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR004825; Ins/IGF/relaxin.
Graphical view of domain structure.
Gene3D G3DSA:1.10.100.10; Ins/IGF/relaxin; 1.
Pfam PF00049; Insulin; 1.
Pfam graphical view of domain structure.
PRINTS PR00276; INSULINA.
PR00277; INSULINB.
ProDom PD001048; Bombyxin; 1.
PD015667; Mollusc_ins; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00078; IlGF; 1.
SMART graphical view of domain structure.
PROSITE PS00262; INSULIN; 1.
BLOCKS P05019.
ProtoNet P05019.
Genome annotation databases
Ensembl ENSG00000017427; Homo sapiens. [Contig view]
GeneID 3479; -.
Phylogenomic databases
HOGENOM P05019; -.
HOVERGEN P05019; -.
Other
LinkHub P05019; -.
NextBio 13678; -.
SOURCE IGF1; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Alternative splicing; Deafness; Direct protein sequencing; Growth factor; Polymorphism; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    21  21     Potential. 
PROPEP   22    48  27      PRO_0000015663
CHAIN   49   118  70     Insulin-like growth factor IB. PRO_0000015664
PROPEP   119   195  77     E peptide. PRO_0000015665
REGION   49    77  29     B. 
REGION   78    89  12     C. 
REGION   90   110  21     A. 
REGION   111   118  8     D. 
DISULFID   54    96         
DISULFID   66   109         
DISULFID   95   100         
VARIANT   187   187  1     A -> D (in dbSNP:rs6213 [NCBI]). VAR_013945 
HELIX   55    66  12      
HELIX   67    69  3      
STRAND   73    76  4      
STRAND   87    90  4      
HELIX   91    95  5      
TURN   96    98  3      
HELIX   102   106  5      
Sequence information
Length: 195 AA [This is the length of the unprocessed precursor] Molecular weight: 21841 Da [This is the MW of the unprocessed precursor] CRC64: E88A8CFBD1CD1873 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MGKISSLPTQ LFKCCFCDFL KVKMHTMSSS HLFYLALCLL TFTSSATAGP ETLCGAELVD 

        70         80         90        100        110        120 
ALQFVCGDRG FYFNKPTGYG SSSRRAPQTG IVDECCFRSC DLRRLEMYCA PLKPAKSARS 

       130        140        150        160        170        180 
VRAQRHTDMP KTQKYQPPST NKNTKSQRRK GWPKTHPGGE QKEGTEASLQ IRGKKKEQRR 

       190 
EIGSRNAECR GKKGK 

P05019 in FASTA format

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View entry in raw text format (no links)
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