ID   IFNW1_HUMAN             Reviewed;         195 AA.
AC   P05000; Q13168; Q5U802; Q5VWD0; Q7M4P5;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 2.
DT   04-NOV-2008, entry version 91.
DE   RecName: Full=Interferon omega-1;
DE   AltName: Full=Interferon alpha-II-1;
DE   Flags: Precursor;
GN   Name=IFNW1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=85187974; PubMed=2985969;
RA   Capon D.J., Shepard H.M., Goeddel D.V.;
RT   "Two distinct families of human and bovine interferon-alpha genes are
RT   coordinately expressed and encode functional polypeptides.";
RL   Mol. Cell. Biol. 5:768-779(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Leukocyte;
RX   MEDLINE=91274345; PubMed=1647209; DOI=10.1016/0167-4781(91)90004-6;
RA   Adolf G.R., Fruehbeis B., Hauptmann R., Kalsner I., Maurer-Fogy I.,
RA   Ostermann E., Patzelt E., Schwendenwein R., Sommergruber W.,
RA   Zoephel A.;
RT   "Human interferon omega 1: isolation of the gene, expression in
RT   Chinese hamster ovary cells and characterization of the recombinant
RT   protein.";
RL   Biochim. Biophys. Acta 1089:167-174(1991).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E.,
RA   Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S.,
RA   Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R.,
RA   Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W.,
RA   Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G.,
RA   Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M.,
RA   Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W.,
RA   Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A.,
RA   Frankland J.A., French L., Fricker D.G., Garner P., Garnett J.,
RA   Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M.,
RA   Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S.,
RA   McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J.,
RA   Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R.,
RA   Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M.,
RA   Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M.,
RA   Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A.,
RA   Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W.,
RA   Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S.,
RA   Rogers J., Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 22-195.
RX   MEDLINE=85269605; PubMed=3895159; DOI=10.1093/nar/13.13.4739;
RA   Hauptmann R., Swetly P.;
RT   "A novel class of human type I interferons.";
RL   Nucleic Acids Res. 13:4739-4749(1985).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 22-195.
RX   PubMed=8142025;
RA   Li M.F., Zeng Q., Zhou Y., Guo H.Y., Hou Y.D.;
RT   "Cloning, sequencing and expression in E. coli of interferon-omega 1
RT   gene.";
RL   Sci. China, Ser. B, Chem. Life Sci. Earth Sci. 36:1361-1366(1993).
RN   [8]
RP   PROTEIN SEQUENCE OF 22-55.
RX   MEDLINE=95036878; PubMed=7765487;
RA   Shirono H., Koga J., Uemura H., Matsuo A.;
RT   "Identification of glycosylated subtypes of interferon-alpha produced
RT   by human leukocytes.";
RL   Biosci. Biotechnol. Biochem. 58:1714-1715(1994).
RN   [9]
RP   PROTEIN SEQUENCE OF 22-36.
RX   PubMed=15340161; DOI=10.1110/ps.04682504;
RA   Zhang Z., Henzel W.J.;
RT   "Signal peptide prediction based on analysis of experimentally
RT   verified cleavage sites.";
RL   Protein Sci. 13:2819-2824(2004).
RN   [10]
RP   PROTEIN SEQUENCE OF 22-33, AND GLYCOSYLATION AT ASN-101.
RX   MEDLINE=90264422; PubMed=1693148;
RA   Adolf G.R., Maurer-Fogy I., Kalsner I., Cantell K.;
RT   "Purification and characterization of natural human interferon omega
RT   1. Two alternative cleavage sites for the signal peptidase.";
RL   J. Biol. Chem. 265:9290-9295(1990).
RN   [11]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 24-195.
RC   TISSUE=Liver;
RA   Yang R.Y., Yang Z.F., Zhu Y.T., Feng L.L., Liu N., Zhao F.,
RA   Zhang F.X., Fu L.C.;
RT   "Human IFN-omega 1 gene isolated from embryonic hepar.";
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the alpha/beta interferon family.
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DR   EMBL; M11003; AAA52724.1; -; Genomic_DNA.
DR   EMBL; X58822; CAA41626.1; -; Genomic_DNA.
DR   EMBL; AL390882; CAH70158.1; -; Genomic_DNA.
DR   EMBL; CH471071; EAW58624.1; -; Genomic_DNA.
DR   EMBL; BC069095; AAH69095.1; -; mRNA.
DR   EMBL; BC117290; AAI17291.1; -; mRNA.
DR   EMBL; BC117292; AAI17293.1; -; mRNA.
DR   EMBL; X02669; CAA26501.1; -; mRNA.
DR   EMBL; A12140; CAA01011.1; -; Unassigned_RNA.
DR   EMBL; U25670; AAA70091.1; -; Genomic_DNA.
DR   EMBL; AY780805; AAV49320.1; -; mRNA.
DR   PIR; A93070; IVHUII.
DR   PIR; PC2204; PC2204.
DR   PIR; PC2205; PC2205.
DR   RefSeq; NP_002168.1; -.
DR   UniGene; Hs.73010; -.
DR   HSSP; P01563; 1ITF.
DR   GlycoSuiteDB; P05000; -.
DR   Ensembl; ENSG00000177047; Homo sapiens.
DR   GeneID; 3467; -.
DR   KEGG; hsa:3467; -.
DR   H-InvDB; HIX0034819; -.
DR   HGNC; HGNC:5448; IFNW1.
DR   MIM; 147553; gene.
DR   PharmGKB; PA29683; -.
DR   HOGENOM; P05000; -.
DR   HOVERGEN; P05000; -.
DR   LinkHub; P05000; -.
DR   NextBio; 13648; -.
DR   ArrayExpress; P05000; -.
DR   CleanEx; HS_IFNW1; -.
DR   GermOnline; ENSG00000177047; Homo sapiens.
DR   GO; GO:0005126; F:hematopoietin/interferon-class (D200-domain...; TAS:ProtInc.
DR   GO; GO:0007050; P:cell cycle arrest; TAS:ProtInc.
DR   GO; GO:0009615; P:response to virus; TAS:ProtInc.
DR   InterPro; IPR012351; 4_helix_cytokine_core.
DR   InterPro; IPR000471; Interferon_abd.
DR   Gene3D; G3DSA:1.20.1250.10; 4_helix_cytokine_core; 1.
DR   PANTHER; PTHR11691; Interferon_abd; 1.
DR   Pfam; PF00143; Interferon; 1.
DR   PRINTS; PR00266; INTERFERONAB.
DR   ProDom; PD000550; Interferon_abd; 1.
DR   SMART; SM00076; IFabd; 1.
DR   PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE   1: Evidence at protein level;
KW   Antiviral defense; Cytokine; Direct protein sequencing; Glycoprotein;
KW   Polymorphism; Secreted; Signal.
FT   SIGNAL        1     21       Or 23 in some molecules.
FT   CHAIN        22    195       Interferon omega-1.
FT                                /FTId=PRO_0000016408.
FT   CARBOHYD    101    101       N-linked (GlcNAc...).
FT                                /FTId=CAR_000050.
FT   DISULFID     24    122       By similarity.
FT   DISULFID     52    162       By similarity.
FT   VARIANT      95     95       R -> S (in dbSNP:rs2230055).
FT                                /FTId=VAR_020028.
FT   CONFLICT     22     23       LG -> EF (in Ref. 7; AAA70091).
FT   CONFLICT     42     42       H -> M (in Ref. 8; AA sequence).
FT   CONFLICT     79     79       V -> A (in Ref. 7; AAA70091).
FT   CONFLICT    111    111       G -> E (in Ref. 1; AAA52724).
FT   CONFLICT    167    167       V -> D (in Ref. 7; AAA70091).
SQ   SEQUENCE   195 AA;  22319 MW;  1E4306F3487987FA CRC64;
     MALLFPLLAA LVMTSYSPVG SLGCDLPQNH GLLSRNTLVL LHQMRRISPF LCLKDRRDFR
     FPQEMVKGSQ LQKAHVMSVL HEMLQQIFSL FHTERSSAAW NMTLLDQLHT GLHQQLQHLE
     TCLLQVVGEG ESAGAISSPA LTLRRYFQGI RVYLKEKKYS DCAWEVVRME IMKSLFLSTN
     MQERLRSKDR DLGSS
//