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UniProtKB/Swiss-Prot entry P04948


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name KHSE_BACSU
Primary accession number P04948
Secondary accession number O32121
Integrated into Swiss-Prot on August 13, 1987
Sequence was last modified on May 30, 2000 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 73)
Name and origin of the protein
Protein name Homoserine kinase
Synonyms HSK
HK
EC 2.7.1.39
Gene name
Name: thrB
OrderedLocusNames: BSU32240
From
Bacillus subtilis [TaxID: 1423] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=168;
PubMed=3098560 [NCBI, ExPASy, EBI, Israel, Japan]
Parsot C.;
"Evolution of biosynthetic pathways: a common ancestor for threonine synthase, threonine dehydratase and D-serine dehydratase.";
EMBO J. 5:3013-3019(1986).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=168;
DOI=10.1038/36786; PubMed=9384377 [NCBI, ExPASy, EBI, Israel, Japan]
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.;
"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.";
Nature 390:249-256(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X04603; CAA28271.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z99120; CAB15214.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR H69722; H69722.
RefSeq NP_391104.1; -.
3D structure databases
ModBase P04948.
Enzyme and pathway databases
BioCyc BSUB224308:BSU3221-MON; -.
Organism-specific databases
SubtiList BG10462; thrB. [Micado]
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from HAMAP).
GO:0004413; Molecular function: homoserine kinase activity (inferred from electronic annotation from HAMAP).
GO:0009088; Biological process: threonine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00384; -; 1.
PBIL [Tree]
InterPro IPR006204; GHMP_kinase.
IPR013750; GHMP_kinase_C.
IPR006203; GHMP_knse_ATP_bd_CS.
IPR000870; Homoser_kin.
IPR014721; Ribosomal_S5_D2-type_fold.
Graphical view of domain structure.
Gene3D G3DSA:3.30.230.10; Ribosomal_S5_D2-type_fold; 1.
Pfam PF08544; GHMP_kinases_C; 1.
PF00288; GHMP_kinases_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000676; Homoser_kin; 1.
PRINTS PR00958; HOMSERKINASE.
TIGRFAMs TIGR00191; thrB; 1.
PROSITE PS00627; GHMP_KINASES_ATP; 1.
BLOCKS P04948.
ProtoNet P04948.
Genome annotation databases
GeneID 936665; -.
GenomeReviews AL009126_GR; BSU32240.
KEGG bsu:BSU32240; -.
NMPDR fig|224308.1.peg.3230; -.
Phylogenomic databases
HOGENOM P04948; -.
Genome annotation databases
CMR P04948; BSU32240.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Threonine biosynthesis; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom  To Length Description FTId
CHAIN   1   309  309     Homoserine kinase. PRO_0000156554
NP_BIND   91   101  11     ATP (Potential). 
CONFLICT   57    58        PA -> R (in Ref. 1; CAA28271). 
Sequence information
Length: 309 AA [This is the length of the unprocessed precursor] Molecular weight: 33324 Da [This is the MW of the unprocessed precursor] CRC64: 0661A7DEFAA5FFAC [This is a checksum on the sequence]
        10         20         30         40         50         60 
MNEADMLFSV TVPGSTANLG PGFDSVGMAL SRYLKLTVFE SDKWSFEAET ETVAGIPAGT 

        70         80         90        100        110        120 
DNLIYQVAKR TADLYGKEMP PVHVKVWSDI PLARGLGSSA AAIVAAIELA DELCGLKLSE 

       130        140        150        160        170        180 
ADKLHLASLE EGHPDNAGAS LVGGLVIGLH EDDETQMIRV PNADIDVVVV IPFYEVLTRD 

       190        200        210        220        230        240 
ARDVLPKEFP YADAVKASAV SNILIAAIMS KDWPLVGKIM KKDMFHQPYR AMLVPELSKV 

       250        260        270        280        290        300 
EHVAEMKGAY GTALSGAGPT ILVMTEKGKG EELKEQLALH FPHCEVDALT VPKEGSIIER 


NPLYQVKSV 

P04948 in FASTA format

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