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[1]
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NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3973974 [NCBI, ExPASy, EBI, Israel, Japan]
Hiebert S.W.,
Paterson R.G.,
Lamb R.A.;
"Hemagglutinin-neuraminidase protein of the paramyxovirus simian virus 5: nucleotide sequence of the mRNA predicts an N-terminal membrane anchor.";
J. Virol. 54:1-6(1985).
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[2]
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NUCLEOTIDE SEQUENCE [GENOMIC RNA].
PubMed=1765772 [NCBI, ExPASy, EBI, Israel, Japan]
Baty D.U.,
Southern J.A.,
Randall R.E.;
"Sequence comparison between the haemagglutinin-neuraminidase genes of simian, canine and human isolates of simian virus 5.";
J. Gen. Virol. 72:3103-3107(1991).
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[3]
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X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 37-565.
DOI=10.1016/j.str.2005.02.019; PubMed=15893670 [NCBI, ExPASy, EBI, Israel, Japan]
Yuan P.,
Thompson T.B.,
Wurzburg B.A.,
Paterson R.G.,
Lamb R.A.,
Jardetzky T.S.;
"Structural studies of the parainfluenza virus 5 hemagglutinin-neuraminidase tetramer in complex with its receptor, sialyllactose.";
Structure 13:803-815(2005).
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- FUNCTION: Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity).
- FUNCTION: Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins (By similarity).
- CATALYTIC ACTIVITY: Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
- SUBCELLULAR LOCATION: Virion membrane; Single-pass type II membrane protein (Potential). Cell membrane; Single-pass type II membrane protein (Potential).
- SIMILARITY: Belongs to the paramyxoviruses hemagglutinin-neuraminidase family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 565 AA [This is the length of the unprocessed precursor] |
Molecular weight: 62205 Da [This is the MW of the unprocessed precursor] |
CRC64: 30A4A7068A25B563 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MVAEDAPVRA TCRVLFRTTT LIFLCTLLAL SISILYESLI TQKQIMSQAG STGSNSGLGS
70 80 90 100 110 120
ITDLLNNILS VANQIIYNSA VALPLQLDTL ESTLLTAIKS LQTSDKLEQN CSWSAALIND
130 140 150 160 170 180
NRYINGINQF YFSIAEGRNL TLGPLLNMPS FIPTATTPEG CTRIPSFSLT KTHWCYTHNV
190 200 210 220 230 240
ILNGCQDHVS SNQFVSMGII EPTSAGFPFF RTLKTLYLSD GVNRKSCSIS TVPGGCMMYC
250 260 270 280 290 300
FVSTQPERDD YFSAAPPEQR IIIMYYNDTI VERIINPPGV LDVWATLNPG TGSGVYYLGW
310 320 330 340 350 360
VLFPIYGGVI KGTSLWNNQA NKYFIPQMVA ALCSQNQATQ VQNAKSSYYS SWFGNRMIQS
370 380 390 400 410 420
GILACPLRQD LTNECLVLPF SNDQVLMGAE GRLYMYGDSV YYYQRSNSWW PMTMLYKVTI
430 440 450 460 470 480
TFTNGQPSAI SAQNVPTQQV PRPGTGDCSA TNRCPGFCLT GVYADAWLLT NPSSTSTFGS
490 500 510 520 530 540
EATFTGSYLN TATQRINPTM YIANNTQIIS SQQFGSSGQE AAYGHTTCFR DTGSVMVYCI
550 560
YIIELSSSLL GQFQIVPFIR QVTLS
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P04850 in FASTA format |
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ExPASy Home page
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