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UniProtKB/Swiss-Prot entry P04813

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CTR2_CANFA
Primary accession number P04813
Secondary accession numbers None
Integrated into Swiss-Prot on August 13, 1987
Sequence was last modified on August 13, 1987 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 65)
Name and origin of the protein
Protein name Chymotrypsinogen 2 [Precursor]
Synonym EC 3.4.21.1
Contains Chymotrypsin 2 chain A
Chymotrypsin 2 chain B
Chymotrypsin 2 chain C
Gene name
Name: CTRB1
Synonyms: CTRB
From
Canis familiaris (Dog) [TaxID: 9615] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
PubMed=6584866 [NCBI, ExPASy, EBI, Israel, Japan]
Pinsky S.D., Laforge K.S., Luc V., Scheele G.;
"Identification of cDNA clones encoding secretory isoenzyme forms: sequence determination of canine pancreatic prechymotrypsinogen 2 mRNA.";
Proc. Natl. Acad. Sci. U.S.A. 80:7486-7490(1983).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
K01173; AAA30841.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A21195; A21195.
RefSeq XP_536781.2; -.
UniGene Cfa.40446
3D structure databases
HSSP P00766; 1ACB. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
SMR P04813; 19-263.
ModBase P04813.
Protein family/group databases
MEROPS S01.152; -.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-KW).
GO:0007586; Biological process: digestion (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001254; Peptidase_S1_S6.
IPR001314; Peptidase_S1A.
Graphical view of domain structure.
Pfam PF00089; Trypsin; 1.
Pfam graphical view of domain structure.
PRINTS PR00722; CHYMOTRYPSIN.
SMART SM00020; Tryp_SPc; 1.
SMART graphical view of domain structure.
PROSITE PS50240; TRYPSIN_DOM; 1.
PS00134; TRYPSIN_HIS; 1.
PS00135; TRYPSIN_SER; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P04813.
ProtoNet P04813.
Genome annotation databases
Ensembl ENSCAFG00000020084; Canis familiaris. [Contig view]
GeneID 479649; -.
KEGG cfa:479649; -.
Phylogenomic databases
HOVERGEN P04813; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Digestion; Hydrolase; Protease; Secreted; Serine protease; Signal; Zymogen.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    18  18      
CHAIN   19   263  245     Chymotrypsinogen 2. PRO_0000027634
CHAIN   19    31  13     Chymotrypsin 2 chain A. PRO_0000027635
CHAIN   34   164  131     Chymotrypsin 2 chain B. PRO_0000027636
CHAIN   167   263  97     Chymotrypsin 2 chain C. PRO_0000027637
DOMAIN   34   261  228     Peptidase S1. 
ACT_SITE   75    75        Charge relay system. 
ACT_SITE   120   120        Charge relay system. 
ACT_SITE   213   213        Charge relay system. 
DISULFID   19   140        By similarity. 
DISULFID   60    76        By similarity. 
DISULFID   154   219        By similarity. 
DISULFID   186   200        By similarity. 
DISULFID   209   238        By similarity. 
Sequence information
Length: 263 AA [This is the length of the unprocessed precursor] Molecular weight: 27787 Da [This is the MW of the unprocessed precursor] CRC64: 2A2F449D813B3961 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAFLWLLSCF ALLGTAFGCG VPAIQPVLSG LSRIVNGEDA VPGSWPWQVS LQDSTGFHFC 

        70         80         90        100        110        120 
GGSLISEDWV VTAAHCGVRT THQVVAGEFD QGSDAESIQV LKIAKVFKNP KFNMFTINND 

       130        140        150        160        170        180 
ITLLKLATPA RFSKTVSAVC LPQATDDFPA GTLCVTTGWG LTKHTNANTP DKLQQAALPL 

       190        200        210        220        230        240 
LSNAECKKFW GSKITDLMVC AGASGVSSCM GDSGGPLVCQ KDGAWTLVGI VSWGSGTCST 

       250        260 
STPGVYARVT KLIPWVQQIL QAN
P04813 in FASTA format

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