ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry P04775

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name SCN2A_RAT
Primary accession number P04775
Secondary accession numbers None
Integrated into Swiss-Prot on August 13, 1987
Sequence was last modified on August 13, 1987 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 86)
Name and origin of the protein
Protein name Sodium channel protein type 2 subunit alpha
Synonyms Sodium channel protein type II subunit alpha
Voltage-gated sodium channel subunit alpha Nav1.2
Sodium channel protein, brain II subunit alpha
Gene name
Name: Scn2a
Synonyms: Scn2a1
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1038/320188a0; PubMed=3754035 [NCBI, ExPASy, EBI, Israel, Japan]
Noda M., Ikeda T., Kayano T., Suzuki H., Takeshima H., Kurasaki M., Takahashi H., Numa S.;
"Existence of distinct sodium channel messenger RNAs in rat brain.";
Nature 320:188-192(1986).
[2]
 INTERACTION WITH NEDD4L, POSSIBLE UBIQUITINATION, AND MUTAGENESIS OF TYR-1975.
DOI=10.1152/ajpcell.00460.2004; PubMed=15548568 [NCBI, ExPASy, EBI, Israel, Japan]
Rougier J.-S., van Bemmelen M.X., Bruce M.C., Jespersen T., Gavillet B., Apotheloz F., Cordonier S., Staub O., Rotin D., Abriel H.;
"Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins.";
Am. J. Physiol. 288:C692-C701(2005).
Comments
  • FUNCTION: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
  • SUBUNIT: The sodium channel consists of a large polypeptide and 2-3 smaller ones. This sequence represents a large polypeptide. Interacts with NEDD4L.
  • SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
  • DOMAIN: The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
  • PTM: May be ubiquitinated by NEDD4L; which would promote its endocytosis.
  • SIMILARITY: Belongs to the sodium channel family.
  • SIMILARITY: Contains 1 IQ domain.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X03639; CAA27287.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_036779.1; -.
UniGene Rn.89192
3D structure databases
PDB
1BYY; NMR; -; A=1474-1526.[ExPASy / RCSB / EBI]
PDBsum 1BYY; -.
ModBase P04775.
PTM databases
PhosphoSite P04775; -.
Organism-specific databases
RGD 3632; Scn2a1.
Gene expression databases
ArrayExpress P04775; -.
GermOnline ENSRNOG00000005018; Rattus norvegicus.
Ontologies
GO
GO:0031402; Molecular function: sodium ion binding (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR005821; Ion_trans.
IPR000048; IQ_CaM_bd_region.
IPR001696; Na_channel.
IPR010526; Na_trans_assoc.
Graphical view of domain structure.
Pfam PF00520; Ion_trans; 4.
PF00612; IQ; 1.
PF06512; Na_trans_assoc; 1.
Pfam graphical view of domain structure.
PRINTS PR00170; NACHANNEL.
SMART SM00015; IQ; 1.
SMART graphical view of domain structure.
PROSITE PS50096; IQ; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P04775.
ProtoNet P04775.
Genome annotation databases
Ensembl ENSRNOG00000005018; Rattus norvegicus. [Contig view]
GeneID 24766; -.
KEGG rno:24766; -.
Phylogenomic databases
HOVERGEN P04775; -.
Other
NextBio 604325; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Glycoprotein; Ion transport; Ionic channel; Membrane; Repeat; Sodium; Sodium channel; Sodium transport; Transmembrane; Transport; Ubl conjugation; Voltage-gated channel.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   2005  2005     Sodium channel protein type 2 subunit alpha. PRO_0000048492
TRANSMEM   125    148  24     S1 of repeat I. 
TRANSMEM   157    176  20     S2 of repeat I. 
TRANSMEM   190    208  19     S3 of repeat I. 
TRANSMEM   215    234  20     S4 of repeat I. 
TRANSMEM   251    274  24     S5 of repeat I. 
TRANSMEM   402    427  26     S6 of repeat I. 
TRANSMEM   754    778  25     S1 of repeat II. 
TRANSMEM   790    813  24     S2 of repeat II. 
TRANSMEM   822    841  20     S3 of repeat II. 
TRANSMEM   848    867  20     S4 of repeat II. 
TRANSMEM   884    904  21     S5 of repeat II. 
TRANSMEM   958    983  26     S6 of repeat II. 
TRANSMEM   1204   1227  24     S1 of repeat III. 
TRANSMEM   1241   1266  26     S2 of repeat III. 
TRANSMEM   1273   1294  22     S3 of repeat III. 
TRANSMEM   1299   1320  22     S4 of repeat III. 
TRANSMEM   1340   1367  28     S5 of repeat III. 
TRANSMEM   1447   1473  27     S6 of repeat III. 
TRANSMEM   1527   1550  24     S1 of repeat IV. 
TRANSMEM   1562   1585  24     S2 of repeat IV. 
TRANSMEM   1592   1615  24     S3 of repeat IV. 
TRANSMEM   1626   1647  22     S4 of repeat IV. 
TRANSMEM   1663   1685  23     S5 of repeat IV. 
TRANSMEM   1752   1776  25     S6 of repeat IV. 
REPEAT   111    456  346     I. 
REPEAT   741   1013  273     II. 
REPEAT   1190   1504  315     III. 
REPEAT   1513   1811  299     IV. 
DOMAIN   1905   1934  30     IQ. 
CARBOHYD   212    212        N-linked (GlcNAc...) (Potential). 
CARBOHYD   285    285        N-linked (GlcNAc...) (Potential). 
CARBOHYD   291    291        N-linked (GlcNAc...) (Potential). 
CARBOHYD   297    297        N-linked (GlcNAc...) (Potential). 
CARBOHYD   303    303        N-linked (GlcNAc...) (Potential). 
CARBOHYD   308    308        N-linked (GlcNAc...) (Potential). 
CARBOHYD   340    340        N-linked (GlcNAc...) (Potential). 
CARBOHYD   604    604        N-linked (GlcNAc...) (Potential). 
CARBOHYD   624    624        N-linked (GlcNAc...) (Potential). 
CARBOHYD   883    883        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1055   1055        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1072   1072        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1136   1136        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1368   1368        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1382   1382        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1393   1393        N-linked (GlcNAc...) (Potential). 
MUTAGEN   1975   1975        Y->A: Abolishes interaction with NEDD4L. 
HELIX   1492   1502  11      
Sequence information
Length: 2005 AA [This is the length of the unprocessed precursor] Molecular weight: 227874 Da [This is the MW of the unprocessed precursor] CRC64: 861BE583D79F8324 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MARSVLVPPG PDSFRFFTRE SLAAIEQRIA EEKAKRPKQE RKDEDDENGP KPNSDLEAGK 

        70         80         90        100        110        120 
SLPFIYGDIP PEMVSEPLED LDPYYINKKT FIVLNKGKAI SRFSATSALY ILTPFNPIRK 

       130        140        150        160        170        180 
LAIKILVHSL FNVLIMCTIL TNCVFMTMSN PPDWTKNVEY TFTGIYTFES LIKILARGFC 

       190        200        210        220        230        240 
LEDFTFLRNP WNWLDFTVIT FAYVTEFVNL GNVSALRTFR VLRALKTISV IPGLKTIVGA 

       250        260        270        280        290        300 
LIQSVKKLSD VMILTVFCLS VFALIGLQLF MGNLRNKCLQ WPPDNSTFEI NITSFFNNSL 

       310        320        330        340        350        360 
DWNGTAFNRT VNMFNWDEYI EDKSHFYFLE GQNDALLCGN SSDAGQCPEG YICVKAGRNP 

       370        380        390        400        410        420 
NYGYTSFDTF SWAFLSLFRL MTQDFWENLY QLTLRAAGKT YMIFFVLVIF LGSFYLINLI 

       430        440        450        460        470        480 
LAVVAMAYEE QNQATLEEAE QKEAEFQQML EQLKKQQEEA QAAAAAASAE SRDFSGAGGI 

       490        500        510        520        530        540 
GVFSESSSVA SKLSSKSEKE LKNRRKKKKQ KEQAGEEEKE DAVRKSASED SIRKKGFQFS 

       550        560        570        580        590        600 
LEGSRLTYEK RFSSPHQSLL SIRGSLFSPR RNSRASLFNF KGRVKDIGSE NDFADDEHST 

       610        620        630        640        650        660 
FEDNDSRRDS LFVPHRHGER RPSNVSQASR ASRGIPTLPM NGKMHSAVDC NGVVSLVGGP 

       670        680        690        700        710        720 
SALTSPVGQL LPEGTTTETE IRKRRSSSYH VSMDLLEDPS RQRAMSMASI LTNTMEELEE 

       730        740        750        760        770        780 
SRQKCPPCWY KFANMCLIWD CCKPWLKVKH VVNLVVMDPF VDLAITICIV LNTLFMAMEH 

       790        800        810        820        830        840 
YPMTEQFSSV LSVGNLVFTG IFTAEMFLKI IAMDPYYYFQ EGWNIFDGFI VSLSLMELGL 

       850        860        870        880        890        900 
ANVEGLSVLR SFRLLRVFKL AKSWPTLNML IKIIGNSVGA LGNLTLVLAI IVFIFAVVGM 

       910        920        930        940        950        960 
QLFGKSYKEC VCKISNDCEL PRWHMHHFFH SFLIVFRVLC GEWIETMWDC MEVAGQTMCL 

       970        980        990       1000       1010       1020 
TVFMMVMVIG NLVVLNLFLA LLLSSFSSDN LAATDDDNEM NNLQIAVGRM QKGIDFVKRK 

      1030       1040       1050       1060       1070       1080 
IREFIQKAFV RKQKALDEIK PLEDLNNKKD SCISNHTTIE IGKDLNYLKD GNGTTSGIGS 

      1090       1100       1110       1120       1130       1140 
SVEKYVVDES DYMSFINNPS LTVTVPIALG ESDFENLNTE EFSSESDMEE SKEKLNATSS 

      1150       1160       1170       1180       1190       1200 
SEGSTVDIGA PAEGEQPEAE PEESLEPEAC FTEDCVRKFK CCQISIEEGK GKLWWNLRKT 

      1210       1220       1230       1240       1250       1260 
CYKIVEHNWF ETFIVFMILL SSGALAFEDI YIEQRKTIKT MLEYADKVFT YIFILEMLLK 

      1270       1280       1290       1300       1310       1320 
WVAYGFQMYF TNAWCWLDFL IVDVSLVSLT ANALGYSELG AIKSLRTLRA LRPLRALSRF 

      1330       1340       1350       1360       1370       1380 
EGMRVVVNAL LGAIPSIMNV LLVCLIFWLI FSIMGVNLFA GKFYHCINYT TGEMFDVSVV 

      1390       1400       1410       1420       1430       1440 
NNYSECQALI ESNQTARWKN VKVNFDNVGL GYLSLLQVAT FKGWMDIMYA AVDSRNVELQ 

      1450       1460       1470       1480       1490       1500 
PKYEDNLYMY LYFVIFIIFG SFFTLNLFIG VIIDNFNQQK KKFGGQDIFM TEEQKKYYNA 

      1510       1520       1530       1540       1550       1560 
MKKLGSKKPQ KPIPRPANKF QGMVFDFVTK QVFDISIMIL ICLNMVTMMV ETDDQSQEMT 

      1570       1580       1590       1600       1610       1620 
NILYWINLVF IVLFTGECVL KLISLRHYYF TIGWNIFDFV VVILSIVGMF LAELIEKYFV 

      1630       1640       1650       1660       1670       1680 
SPTLFRVIRL ARIGRILRLI KGAKGIRTLL FALMMSLPAL FNIGLLLFLV MFIYAIFGMS 

      1690       1700       1710       1720       1730       1740 
NFAYVKREVG IDDMFNFETF GNSMICLFQI TTSAGWDGLL APILNSGPPD CDPEKDHPGS 

      1750       1760       1770       1780       1790       1800 
SVKGDCGNPS VGIFFFVSYI IISFLVVVNM YIAVILENFS VATEESAEPL SEDDFEMFYE 

      1810       1820       1830       1840       1850       1860 
VWEKFDPDAT QFIEFCKLSD FAAALDPPLL IAKPNKVQLI AMDLPMVSGD RIHCLDILFA 

      1870       1880       1890       1900       1910       1920 
FTKRVLGESG EMDALRIQME ERFMASNPSK VSYEPITTTL KRKQEEVSAI VIQRAYRRYL 

      1930       1940       1950       1960       1970       1980 
LKQKVKKVSS IYKKDKGKED EGTPIKEDII TDKLNENSTP EKTDVTPSTT SPPSYDSVTK 

      1990       2000 
PEKEKFEKDK SEKEDKGKDI RESKK
P04775 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA) 		Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Hosted by ch flag SIB Switzerland Mirror sites: Australia Brazil Canada China Korea
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!