[1]
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NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1038/319230a0; PubMed=3003577 [NCBI, ExPASy, EBI, Israel, Japan]
Yamamoto T.,
Ikawa S.,
Akiyama T.,
Semba K.,
Nomura N.,
Miyajima N.,
Saito T.,
Toyoshima K.;
"Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor.";
Nature 319:230-234(1986).
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[2]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND VARIANT ALA-1170.
PubMed=2999974 [NCBI, ExPASy, EBI, Israel, Japan]
Coussens L.,
Yang-Feng T.L.,
Liao Y.C.,
Chen E.,
Gray A.,
McGrath J.,
Seeburg P.H.,
Libermann T.A.,
Schlessinger J.,
Francke U.,
Levinson A.,
Ullrich A.;
"Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene.";
Science 230:1132-1139(1985).
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[3]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS CYS-452; VAL-655 AND ALA-1170.
Rieder M.J.,
Livingston R.J.,
Daniels M.R.,
Montoya M.A.,
Chung M.-W.,
Miyamoto K.E.,
Nguyen C.P.,
Nguyen D.A.,
Poel C.L.,
Robertson P.D.,
Schackwitz W.S.,
Sherwood J.K.,
Witrak L.A.,
Nickerson D.A.;
"NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu).";
Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
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[4]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-191.
PubMed=3039351 [NCBI, ExPASy, EBI, Israel, Japan]
Tal M.,
King C.R.,
Kraus M.H.,
Ullrich A.,
Schlessinger J.,
Givol D.;
"Human HER2 (neu) promoter: evidence for multiple mechanisms for transcriptional initiation.";
Mol. Cell. Biol. 7:2597-2601(1987).
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[5]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 737-1031.
PubMed=2995967 [NCBI, ExPASy, EBI, Israel, Japan]
Semba K.,
Kamata N.,
Toyoshima K.,
Yamamoto T.;
"A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma.";
Proc. Natl. Acad. Sci. U.S.A. 82:6497-6501(1985).
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[6]
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NUCLEOTIDE SEQUENCE OF 832-909.
TISSUE=Mammary carcinoma;
PubMed=2992089 [NCBI, ExPASy, EBI, Israel, Japan]
King C.R.,
Kraus M.H.,
Aaronson S.A.;
"Amplification of a novel v-erbB-related gene in a human mammary carcinoma.";
Science 229:974-976(1985).
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[7]
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NUCLEOTIDE SEQUENCE OF 1081-1245, AND VARIANT ALA-1170.
PubMed=8104414 [NCBI, ExPASy, EBI, Israel, Japan]
Sarkar F.H.,
Ball D.E.,
Li Y.W.,
Crissman J.D.;
"Molecular cloning and sequencing of an intron of Her-2/neu (ERBB2) gene.";
DNA Cell Biol. 12:611-615(1993).
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[8]
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IDENTIFICATION IN A COMPLEX WITH PIK3C2A AND EGFR, IDENTIFICATION IN A COMPLEX WITH PIK3C2B AND EGFR, AND INTERACTION WITH PIK3C2B.
DOI=10.1128/MCB.20.11.3817-3830.2000; PubMed=10805725 [NCBI, ExPASy, EBI, Israel, Japan]
Arcaro A.,
Zvelebil M.J.,
Wallasch C.,
Ullrich A.,
Waterfield M.D.,
Domin J.;
"Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors.";
Mol. Cell. Biol. 20:3817-3830(2000).
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[9]
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INTERACTION WITH MUC1.
PubMed=12939402 [NCBI, ExPASy, EBI, Israel, Japan]
Li Y.,
Yu W.-H.,
Ren J.,
Chen W.,
Huang L.,
Kharbanda S.,
Loda M.,
Kufe D.;
"Heregulin targets gamma-catenin to the nucleolus by a mechanism dependent on the DF3/MUC1 oncoprotein.";
Mol. Cancer Res. 1:765-775(2003).
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[10]
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INTERACTION WITH PLXNB1.
DOI=10.1083/jcb.200312094; PubMed=15210733 [NCBI, ExPASy, EBI, Israel, Japan]
Swiercz J.M.,
Kuner R.,
Offermanns S.;
"Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2.";
J. Cell Biol. 165:869-880(2004).
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[11]
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INTERACTION WITH MEMO.
DOI=10.1038/ncb1134; PubMed=15156151 [NCBI, ExPASy, EBI, Israel, Japan]
Marone R.,
Hess D.,
Dankort D.,
Muller W.J.,
Hynes N.E.,
Badache A.;
"Memo mediates ErbB2-driven cell motility.";
Nat. Cell Biol. 6:515-522(2004).
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[12]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1248, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1016/j.cell.2006.09.026; PubMed=17081983 [NCBI, ExPASy, EBI, Israel, Japan]
Olsen J.V.,
Blagoev B.,
Gnad F.,
Macek B.,
Kumar C.,
Mortensen P.,
Mann M.;
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.";
Cell 127:635-648(2006).
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[13]
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X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 654-662 IN COMPLEX WITH HLA AND BETA-2 MICROGLOBULIN.
DOI=10.1074/jbc.274.51.36422; PubMed=10593938 [NCBI, ExPASy, EBI, Israel, Japan]
Kuhns J.J.,
Batalia M.A.,
Yan S.,
Collins E.J.;
"Poor binding of a HER-2/neu epitope (GP2) to HLA-A2.1 is due to a lack of interactions with the center of the peptide.";
J. Biol. Chem. 274:36422-36427(1999).
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[14]
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X-RAY CRYSTALLOGRAPHY (2.52 ANGSTROMS) OF 23-629 IN COMPLEX WITH FAB.
DOI=10.1038/nature01392; PubMed=12610629 [NCBI, ExPASy, EBI, Israel, Japan]
Cho H.-S.,
Mason K.,
Ramyar K.X.,
Stanley A.M.,
Gabelli S.B.,
Denney D.W. Jr.,
Leahy D.J.;
"Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab.";
Nature 421:756-760(2003).
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[15]
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VARIANTS VAL-654 AND VAL-655.
DOI=10.1006/geno.1993.1081; PubMed=8095488 [NCBI, ExPASy, EBI, Israel, Japan]
Ehsani A.,
Low J.,
Wallace R.B.,
Wu A.M.;
"Characterization of a new allele of the human ERBB2 gene by allele-specific competition hybridization.";
Genomics 15:426-429(1993).
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[16]
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VARIANTS [LARGE SCALE ANALYSIS] VAL-654; VAL-655; SER-768; SER-776; SER-857; ALA-1170 AND ASP-1216.
DOI=10.1038/nature05610; PubMed=17344846 [NCBI, ExPASy, EBI, Israel, Japan]
Greenman C.,
Stephens P.,
Smith R.,
Dalgliesh G.L.,
Hunter C.,
Bignell G.,
Davies H.,
Teague J.,
Butler A.,
Stevens C.,
Edkins S.,
O'Meara S.,
Vastrik I.,
Schmidt E.E.,
Avis T.,
Barthorpe S.,
Bhamra G.,
Buck G.,
Choudhury B., ![]()
Clements J.,
Cole J.,
Dicks E.,
Forbes S.,
Gray K.,
Halliday K.,
Harrison R.,
Hills K.,
Hinton J.,
Jenkinson A.,
Jones D.,
Menzies A.,
Mironenko T.,
Perry J.,
Raine K.,
Richardson D.,
Shepherd R.,
Small A.,
Tofts C.,
Varian J.,
Webb T.,
West S.,
Widaa S.,
Yates A.,
Cahill D.P.,
Louis D.N.,
Goldstraw P.,
Nicholson A.G.,
Brasseur F.,
Looijenga L.,
Weber B.L.,
Chiew Y.-E.,
DeFazio A.,
Greaves M.F.,
Green A.R.,
Campbell P.,
Birney E.,
Easton D.F.,
Chenevix-Trench G.,
Tan M.-H.,
Khoo S.K.,
Teh B.T.,
Yuen S.T.,
Leung S.Y.,
Wooster R.,
Futreal P.A.,
Stratton M.R.;
"Patterns of somatic mutation in human cancer genomes.";
Nature 446:153-158(2007).
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