[1]	PROTEIN SEQUENCE. TISSUE=Gastric mucosa; DOI=10.1016/0196-9781(86)90045-8; PubMed=3763441 [NCBI, ExPASy, EBI, Israel, Japan] Bonato C., Eng J., Hulmes J.D., Miedel M., Pan Y.-C.E., Yalow R.S.; "Sequences of gastrins purified from a single antrum of dog and of goat."; Peptides 7:689-693(1986).

Comments

FUNCTION: Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
SUBCELLULAR LOCATION: Secreted.
SIMILARITY: Belongs to the gastrin/cholecystokinin family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases
PIR	JS0426; JS0426.
3D structure databases
ModBase	P04564.
Family and domain databases
InterPro	IPR001651; Gastrin. IPR013152; Gastrin_CCK_CS. Graphical view of domain structure.
Pfam	PF00918; Gastrin; 1. Pfam graphical view of domain structure.
PROSITE	PS00259; GASTRIN; 1.
BLOCKS	P04564.
ProtoNet	P04564.
Phylogenomic databases
HOVERGEN	P04564; -.
Other
UniRef	View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amidation; Cleavage on pair of basic residues; Direct protein sequencing; Hormone; Pyrrolidone carboxylic acid; Secreted; Sulfation.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`PEPTIDE`	`1 34`	`34`	`Big gastrin.`	`PRO_0000010617`
`PEPTIDE`	`18 34`	`17`	`Gastrin.`	`PRO_0000010618`
`MOD_RES`	`1 1`		`Pyrrolidone carboxylic acid.`
`MOD_RES`	`18 18`		`Pyrrolidone carboxylic acid.`
`MOD_RES`	`29 29`		`Sulfotyrosine.`
`MOD_RES`	`34 34`		`Phenylalanine amide.`

Sequence information

Length: 34 AA [This is the length of the unprocessed precursor]

Molecular weight: 3903 Da [This is the MW of the unprocessed precursor]

CRC64: 67501111E76D0CF4 [This is a checksum on the sequence]

        10         20         30 
QLGLQDPPHM VADLSKKQGP WVEEEEAAYG WMDF

P04564 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools