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[1]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Gastric antrum;
PubMed=3453895 [NCBI, ExPASy, EBI, Israel, Japan]
Fuller P.J.,
Stone D.L.,
Brand S.J.;
"Molecular cloning and sequencing of a rat preprogastrin complementary deoxyribonucleic acid.";
Mol. Endocrinol. 1:306-311(1987).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] OF 56-92.
DOI=10.1016/0196-9781(82)90172-3; PubMed=6897117 [NCBI, ExPASy, EBI, Israel, Japan]
Schaffer M.H.,
Agarwal K.L.,
Noyes B.E.;
"Rat gastrin's amino acid sequence determined from the nucleotide sequence of the mRNA.";
Peptides 3:693-696(1982).
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[3]
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PROTEOLYTIC PROCESSING, PHOSPHORYLATION AT SER-96, SULFATION AT TYR-87 AND TYR-103, AND AMIDATION AT PHE-92.
PubMed=1701434 [NCBI, ExPASy, EBI, Israel, Japan]
Varro A.,
Nemeth J.,
Bridson J.,
Lee C.,
Moore S.,
Dockray G.J.;
"Processing of the gastrin precursor. Modulation of phosphorylated, sulfated, and amidated products.";
J. Biol. Chem. 265:21476-21481(1990).
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- FUNCTION: Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
- SUBCELLULAR LOCATION: Secreted.
- PTM: Sulfation on Tyr-87 enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins and between tissues (By similarity).
- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 104 AA [This is the length of the unprocessed precursor] |
Molecular weight: 11832 Da [This is the MW of the unprocessed precursor] |
CRC64: 973FD06276BF1E21 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MPRLCVCMLV LVLALATFSE ASWKPRSQLQ DASSGPRTNG ALEQHQLEKL GPASHHRRQL
70 80 90 100
GPQGPQHFIA DLSKKQRPPM EEEEEAYGWM DFGRRSAEEE DQYN
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P04563 in FASTA format |
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ExPASy Home page
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