NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2994050 [NCBI, ExPASy, EBI, Israel, Japan]
Pellett P.E., McKnight J.L.C., Jenkins F.J., Roizman B.;
"Nucleotide sequence and predicted amino acid sequence of a protein encoded in a small herpes simplex virus DNA fragment capable of trans-inducing alpha genes.";
Proc. Natl. Acad. Sci. U.S.A. 82:5870-5874(1985).

Comments

FUNCTION: Responsible for transcriptional activation of immediate early promoters (alpha genes). Activation requires the formation of a heteromeric complex with the host cell factor. These two proteins then assemble with the octamer motif-binding protein Oct-1 on the cis-acting target sequence: 5'-TAATGARAT-3'.
SIMILARITY: Belongs to the herpesviridae alpha trans-inducing protein family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

K03350; AAA45766.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

A03727; IXBE1F.

3D structure databases

PDB

2K2U; NMR; -; B=445-479.

[ExPASy / RCSB / EBI]

PDBsum

2K2U; -.

ModBase

P04486.

Family and domain databases

InterPro

IPR003174; Alpha_TIF.
Graphical view of domain structure.

Gene3D

G3DSA:1.10.1290.10; Alpha_TIF; 1.

Pfam

PF02232; Alpha_TIF; 1.
Pfam graphical view of domain structure.

SMART

SM00814; Alpha_TIF; 1.
SMART graphical view of domain structure.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

3D-structure; DNA-binding; Transcription; Transcription regulation.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 479`	`479`		`Alpha trans-inducing protein.`	`PRO_0000115799`

Sequence information

Length: 479 AA [This is the length of the unprocessed precursor]

Molecular weight: 53054 Da [This is the MW of the unprocessed precursor]

CRC64: 8DFF24AC1717A1C6 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MDADGASPPP PRPAGGPKNT PAAPPLYATG RLSQAQLMPS PPMPVPPAAL FNRLLDDLGF 

        70         80         90        100        110        120 
SAGPALCTML DTWNEDLFSA LPTNADLYRE CKFLSTLPSD VVEWGDAYVP ERAQIDIRAH 

       130        140        150        160        170        180 
GDVAFPTLPA TRDGLGLYYE ALSRFFHAEL RAREESYRTV LANFCSALYR YLRASVRQLH 

       190        200        210        220        230        240 
RQAHMRGRDR DLGEMLRATI ADRYYRETAR LARVLFLHLY LFLTREILWA AYAEQMMRPD 

       250        260        270        280        290        300 
LFDCLCCDLE SWRQLAGLFQ PFMFVNGALT VRGVPIEARR LRELNHIREH LNLPLVRSAA 

       310        320        330        340        350        360 
TEEPGAPLTT PPTLHGNQAR ASGYFMVLIR AKLDSYSSFT TSPSEAVMRE HAYSRARTKN 

       370        380        390        400        410        420 
NYGSTIEGLL DLPDDDAPEE AGLAAPRLSF LPAGHTRRLS TAPPTDVSLG DELHLDGEDV 

       430        440        450        460        470 
AMAHADALDD FDLDMLGDGD SPGPGFTPHD SAPYGALDMA DFEFEQMFTD ALGIDEYGG

P04486 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools