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[1]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2839594 [NCBI, ExPASy, EBI, Israel, Japan]
McGeoch D.J.,
Dalrymple M.A.,
Davison A.J.,
Dolan A.,
Frame M.C.,
McNab D.,
Perry L.J.,
Scott J.E.,
Taylor P.;
"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1.";
J. Gen. Virol. 69:1531-1574(1988).
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[2]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1093/nar/14.8.3435; PubMed=3010237 [NCBI, ExPASy, EBI, Israel, Japan]
McGeoch D.J.,
Dolan A.,
Frame M.C.;
"DNA sequence of the region in the genome of herpes simplex virus type 1 containing the exonuclease gene and neighbouring genes.";
Nucleic Acids Res. 14:3435-3448(1986).
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[3]
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MYRISTOYLATION AT GLY-2, AND SUBCELLULAR LOCATION.
PubMed=1312117 [NCBI, ExPASy, EBI, Israel, Japan]
MacLean C.A.,
Dolan A.,
Jamieson F.E.,
McGeoch D.J.;
"The myristylated virion proteins of herpes simplex virus type 1: investigation of their role in the virus life cycle.";
J. Gen. Virol. 73:539-547(1992).
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[4]
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INTERACTION WITH UL16.
STRAIN=KOS;
DOI=10.1128/JVI.77.21.11417-11424.2003; PubMed=14557627 [NCBI, ExPASy, EBI, Israel, Japan]
Loomis J.S.,
Courtney R.J.,
Wills J.W.;
"Binding partners for the UL11 tegument protein of herpes simplex virus type 1.";
J. Virol. 77:11417-11424(2003).
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[5]
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INTERACTION WITH UL16.
STRAIN=KOS;
DOI=10.1128/JVI.01230-08; PubMed=18715918 [NCBI, ExPASy, EBI, Israel, Japan]
Yeh P.-C.,
Meckes D.G. Jr.,
Wills J.W.;
"Analysis of the interaction between the UL11 and UL16 tegument proteins of herpes simplex virus.";
J. Virol. 82:10693-10700(2008).
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- FUNCTION: May play a role in the virus budding process at the trans-Golgi network during nucleocapsid envelopment (Potential).
- SUBUNIT: Interacts with UL16.
- SUBCELLULAR LOCATION: Virion tegument. Virion membrane; Lipid-anchor (By similarity). Host cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Host Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side (Potential). Host nucleus membrane (By similarity). Note=Host membrane-associated tegument protein (about 700 copies per virion). Associates with host membrane lipids rafts (By similarity).
- DOMAIN: The acidic region is required for efficient packaging. It is also involved in recycling the protein from the plasma membrane to the Golgi apparatus, and in the interaction with UL16 (By similarity).
- PTM: Myristoylation and palmitoylation (probably on one or more of the nearby cysteines at the N-terminus) enable membrane-binding and Golgi apparatus-specific targeting and are essential for efficient packaging (By similarity).
- PTM: Phosphorylated. Packaging is selective for underphosphorylated forms (By similarity).
- SIMILARITY: Belongs to the herpesviridae HHV-1 UL11 family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 96 AA [This is the length of the unprocessed precursor] |
Molecular weight: 10487 Da [This is the MW of the unprocessed precursor] |
CRC64: 5D09A5B1F2034B09 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MGLSFSGARP CCCRNNVLIT DDGEVVSLTA HDFDVVDIES EEEGNFYVPP DMRGVTRAPG
70 80 90
RQRLRSSDPP SRHTHRRTPG GACPATQFPP PMSDSE
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P04289 in FASTA format |
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