[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. PubMed=2839594 [NCBI, ExPASy, EBI, Israel, Japan] McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.; "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."; J. Gen. Virol. 69:1531-1574(1988).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. DOI=10.1093/nar/14.8.3435; PubMed=3010237 [NCBI, ExPASy, EBI, Israel, Japan] McGeoch D.J., Dolan A., Frame M.C.; "DNA sequence of the region in the genome of herpes simplex virus type 1 containing the exonuclease gene and neighbouring genes."; Nucleic Acids Res. 14:3435-3448(1986).
[3]	NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-98. PubMed=2826807 [NCBI, ExPASy, EBI, Israel, Japan] McGeoch D.J., Dalrymple M.A., Dolan A., McNab D., Perry L.J., Taylor P., Challberg M.D.; "Structures of herpes simplex virus type 1 genes required for replication of virus DNA."; J. Virol. 62:444-453(1988).
[4]	SUBCELLULAR LOCATION. STRAIN=F; DOI=10.1128/JVI.01756-06; PubMed=17079321 [NCBI, ExPASy, EBI, Israel, Japan] Baines J.D., Wills E., Jacob R.J., Pennington J., Roizman B.; "Glycoprotein M of herpes simplex virus 1 is incorporated into virions during budding at the inner nuclear membrane."; J. Virol. 81:800-812(2007).

Comments

FUNCTION: Fusion and/or entry and cell-to-cell spread (By similarity).
SUBUNIT: Interacts with gN (By similarity). The gM-gN heterodimer forms the gCII complex (By similarity).
SUBCELLULAR LOCATION: Virion membrane; Multi-pass membrane protein (Potential). Nucleus inner membrane; Multi-pass membrane protein (Probable). Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Becomes incorporated into the virion envelope upon budding through the inner nuclear membrane.
DOMAIN: The proline-rich cytoplasmic tail might interact with the virion tegument.
SIMILARITY: Belongs to the herpesviridae glycoprotein M family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X14112; CAA32346.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X03839; CAA27451.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M19120; AAA45821.2; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

A03736; WMBE51.

RefSeq

NP_044611.1; -.

3D structure databases

ModBase

P04288.

Ontologies

GO:0030659;	Cellular component: cytoplasmic vesicle membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0016021;	Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005637;	Cellular component: nuclear inner membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0019031;	Cellular component: viral envelope (inferred from electronic annotation from UniProtKB-KW).
GO:0055036;	Cellular component: virion membrane (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.

Family and domain databases

InterPro

IPR000785; Herpes_glycop.
Graphical view of domain structure.

Pfam

PF01528; Herpes_glycop; 1.
Pfam graphical view of domain structure.

PRINTS

PR00333; HSVINTEGRLMP.

Genome annotation databases

GeneID

2703379; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Cytoplasmic vesicle; Envelope protein; Glycoprotein; Membrane; Nucleus; Transmembrane; Virion.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 473`	`473`	`Glycoprotein M.`	`PRO_0000115775`
`TRANSMEM`	`33 53`	`21`	`Potential.`
`TRANSMEM`	`91 111`	`21`	`Potential.`
`TRANSMEM`	`138 158`	`21`	`Potential.`
`TRANSMEM`	`164 184`	`21`	`Potential.`
`TRANSMEM`	`217 237`	`21`	`Potential.`
`TRANSMEM`	`251 271`	`21`	`Potential.`
`TRANSMEM`	`281 301`	`21`	`Potential.`
`TRANSMEM`	`319 339`	`21`	`Potential.`
`TOPO_DOM`	`340 473`	`134`	`Cytoplasmic (Potential).`
`CARBOHYD`	`71 71`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`246 246`		`N-linked (GlcNAc...) (Potential).`

Sequence information

Length: 473 AA [This is the length of the unprocessed precursor]

Molecular weight: 51393 Da [This is the MW of the unprocessed precursor]

CRC64: E08FD792409A81E6 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGRPAPRGSP DSAPPTKGMT GARTAWWVWC VQVATFVVSA VCVTGLLVLA SVFRARFPCF 

        70         80         90        100        110        120 
YATASSYAGV NSTAEVRGGV AVPLRLDTQS LVGTYVITAV LLLAVAVYAV VGAVTSRYDR 

       130        140        150        160        170        180 
ALDAGRRLAA ARMAMPHATL IAGNVCSWLL QITVLLLAHR ISQLAHLVYV LHFACLVYFA 

       190        200        210        220        230        240 
AHFCTRGVLS GTYLRQVHGL MELAPTHHRV VGPARAVLTN ALLLGVFLCT ADAAVSLNTI 

       250        260        270        280        290        300 
AAFNFNFSAP GMLICLTVLF AILVVSLLLV VEGVLCHYVR VLVGPHLGAV AATGIVGLAC 

       310        320        330        340        350        360 
EHYYTNGYYV VETQWPGAQT GVRVALALVA AFALGMAVLR CTRAYLYHRR HHTKFFMRMR 

       370        380        390        400        410        420 
DTRHRAHSAL KRVRSSMRGS RDGRHRPAPG SPPGIPEYAE DPYAISYGGQ LDRYGDSDGE 

       430        440        450        460        470 
PIYDEVADDQ TDVLYAKIQH PRHLPDDDPI YDTVGGYDPE PAEDPVYSTV RRW

P04288 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools