[1]
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PROTEIN SEQUENCE (ISOFORM 1).
PubMed=3997866 [NCBI, ExPASy, EBI, Israel, Japan]
Lau S.Y.M.,
Sanders C.,
Smillie L.B.;
"Amino acid sequence of chicken gizzard gamma-tropomyosin.";
J. Biol. Chem. 260:7257-7263(1985).
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[2]
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NUCLEOTIDE SEQUENCE (ISOFORM 1).
DOI=10.1093/nar/15.19.8105; PubMed=3671073 [NCBI, ExPASy, EBI, Israel, Japan]
Gooding C.,
Reinach F.C.,
Macleod A.R.;
"Complete nucleotide sequence of the fast-twitch isoform of chicken skeletal muscle alpha-tropomyosin.";
Nucleic Acids Res. 15:8105-8105(1987).
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[3]
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NUCLEOTIDE SEQUENCE (ISOFORMS 1; 2; 4; 5; 6 AND 7).
DOI=10.1016/0378-1119(91)90323-4; PubMed=1748294 [NCBI, ExPASy, EBI, Israel, Japan]
Lemonnier M.,
Balvay L.,
Mouly V.,
Libri D.,
Fiszman M.Y.;
"The chicken gene encoding the alpha isoform of tropomyosin of fast-twitch muscle fibers: organization, expression and identification of the major proteins synthesized.";
Gene 107:229-240(1991).
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[4]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 4).
TISSUE=Body wall;
PubMed=7820856 [NCBI, ExPASy, EBI, Israel, Japan]
Fanning A.S.,
Wolenski J.S.,
Mooseker M.S.,
Izant J.G.;
"Differential regulation of skeletal muscle myosin-II and brush border myosin-I enzymology and mechanochemistry by bacterially produced tropomyosin isoforms.";
Cell Motil. Cytoskeleton 29:29-45(1994).
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[5]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Heart, and Skeletal muscle;
Denz C.R.,
Zajdel R.W.,
Dube S.,
Dube D.K.;
"Identification, characterization, and expression of a novel alpha-tropomyosin isoform in cardiac tissues in developing chicken.";
Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
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[6]
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NUCLEOTIDE SEQUENCE [MRNA] OF 24-284 (ISOFORM 1).
PubMed=7128591 [NCBI, ExPASy, EBI, Israel, Japan]
McLeod A.R.;
"Distinct alpha-tropomyosin mRNA sequences in chicken skeletal muscle.";
Eur. J. Biochem. 126:293-297(1982).
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[7]
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NUCLEOTIDE SEQUENCE OF 189-213 (ISOFORM 4).
TISSUE=Muscle;
DOI=10.1093/nar/17.13.5400; PubMed=2762137 [NCBI, ExPASy, EBI, Israel, Japan]
Lemonnier M.,
Libri D.,
Fiszman M.Y.;
"Chick alpha tropomyosin gene contains three sets of mutually exclusive alternatively spliced exons.";
Nucleic Acids Res. 17:5400-5400(1989).
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[8]
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X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 1-81.
DOI=10.1073/pnas.131219198; PubMed=11438684 [NCBI, ExPASy, EBI, Israel, Japan]
Brown J.H.,
Kim K.H.,
Jun G.,
Greenfield N.J.,
Dominguez R.,
Volkmann N.,
Hitchcock-DeGregori S.E.,
Cohen C.;
"Deciphering the design of the tropomyosin molecule.";
Proc. Natl. Acad. Sci. U.S.A. 98:8496-8501(2001).
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- FUNCTION: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
- SUBUNIT: Heterodimer of an alpha and a beta chain.
- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
- ALTERNATIVE PRODUCTS:
6 named isoforms [FASTA] produced by alternative splicing. Additional isoforms seem to exist.
| Name | 1 |
| Synonyms | Fast-twitch skeletal muscle, CTm7 |
| Isoform ID | P04268-1 |
| This is the isoform sequence displayed in this entry. |
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| Name | 5 |
| Synonyms | Fibroblast F2 |
| Isoform ID | P04268-5 |
| Features which should be applied to build the isoform sequence: VSP_006590. |
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| Name | 7 |
| Synonyms | Brain minor |
| Isoform ID | P04268-7 |
| Features which should be applied to build the isoform sequence: VSP_006591. |
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- DOMAIN: The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
- SIMILARITY: Belongs to the tropomyosin family.
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