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UniProtKB/Swiss-Prot entry P04186

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CFAB_MOUSE
Primary accession number P04186
Secondary accession numbers None
Integrated into Swiss-Prot on March 20, 1987
Sequence was last modified on August 1, 1991 (Sequence version 2)
Annotations were last modified on    November 4, 2008 (Entry version 95)
Name and origin of the protein
Protein name Complement factor B [Precursor]
Synonyms EC 3.4.21.47
C3/C5 convertase
Contains Complement factor B Ba fragment
Complement factor B Bb fragment
Gene name
Name: Cfb
Synonyms: Bf, H2-Bf
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2229060 [NCBI, ExPASy, EBI, Israel, Japan]
Ishikawa N., Nonaka M., Wetsel R.A., Colten H.R.;
"Murine complement C2 and factor B genomic and cDNA cloning reveals different mechanisms for multiple transcripts of C2 and B.";
J. Biol. Chem. 265:19040-19046(1990).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=129;
DOI=10.1101/gr.1736803; PubMed=14656967 [NCBI, ExPASy, EBI, Israel, Japan]
Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.;
"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.";
Genome Res. 13:2621-2636(2003).
[3]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Czech II;
TISSUE=Mammary gland;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
 NUCLEOTIDE SEQUENCE [MRNA] OF 285-761.
PubMed=6689022 [NCBI, ExPASy, EBI, Israel, Japan]
Sackstein R., Colten H.R., Woods D.E.;
"Phylogenetic conservation of a class III major histocompatibility complex antigen, factor B. Isolation and nucleotide sequencing of mouse factor B cDNA clones.";
J. Biol. Chem. 258:14693-14697(1983).
[5]
 GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-282, AND MASS SPECTROMETRY.
TISSUE=Plasma;
DOI=10.1021/pr060186m; PubMed=16944957 [NCBI, ExPASy, EBI, Israel, Japan]
Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.;
"Proteome-wide characterization of N-glycosylation events by diagonal chromatography.";
J. Proteome Res. 5:2438-2447(2006).
[6]
 GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-119, AND MASS SPECTROMETRY.
TISSUE=Plasma;
DOI=10.1021/pr0604559; PubMed=17330941 [NCBI, ExPASy, EBI, Israel, Japan]
Bernhard O.K., Kapp E.A., Simpson R.J.;
"Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides.";
J. Proteome Res. 6:987-995(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M60646; AAA37379.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M60629; AAA37379.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M60630; AAA37379.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M60631; AAA37379.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M60632; AAA37379.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M60633; AAA37379.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M60634; AAA37379.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M60635; AAA37379.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M60636; AAA37379.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M60637; AAA37379.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M60638; AAA37379.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M60639; AAA37379.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M60640; AAA37379.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M60641; AAA37379.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M60642; AAA37379.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M60643; AAA37379.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M60644; AAA37379.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M60645; AAA37379.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF049850; AAC05283.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF109906; AAC84160.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC005451; AAH05451.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
K01496; AAA39549.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
K01497; AAA39550.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
K01498; AAA39551.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M57890; AAA63293.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A38875; BBMS.
RefSeq NP_032224.1; -.
UniGene Mm.653
3D structure databases
HSSP P08174; 1H03. [HSSP ENTRY / PDB]
SMR P04186; 31-761.
ModBase P04186.
Protein family/group databases
MEROPS S01.196; -.
Organism-specific databases
MGI MGI:105975; Cfb.
Gene expression databases
CleanEx MM_CFB; -.
GermOnline ENSMUSG00000024371; Mus musculus.
Ontologies
GO
GO:0008283; Biological process: cell proliferation (traceable author statement from MGI).
GO:0006957; Biological process: complement activation, alternative pathway (inferred from mutant phenotype from MGI).
QuickGo view.
Family and domain databases
InterPro IPR011360; Compl_C2_B.
IPR016060; Complement_control_module.
IPR001254; Peptidase_S1_S6.
IPR001314; Peptidase_S1A.
IPR000436; Sushi_SCR_CCP.
IPR002035; VWF_A.
Graphical view of domain structure.
Gene3D G3DSA:2.10.70.10; Complement_control_module; 2.
Pfam PF00084; Sushi; 2.
PF00089; Trypsin; 1.
PF00092; VWA; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF001154; Compl_C2_B; 1.
PRINTS PR00722; CHYMOTRYPSIN.
PR00453; VWFADOMAIN.
SMART SM00032; CCP; 3.
SM00020; Tryp_SPc; 1.
SM00327; VWA; 1.
SMART graphical view of domain structure.
PROSITE PS50923; SUSHI; 3.
PS50240; TRYPSIN_DOM; 1.
PS00134; TRYPSIN_HIS; 1.
PS00135; TRYPSIN_SER; 1.
PS50234; VWFA; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P04186.
ProtoNet P04186.
Genome annotation databases
Ensembl ENSMUSG00000024371; Mus musculus. [Contig view]
GeneID 14962; -.
KEGG mmu:14962; -.
Phylogenomic databases
HOGENOM P04186; -.
HOVERGEN P04186; -.
Other
NextBio 287314; -.
SOURCE Cfb; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cleavage on pair of basic residues; Complement alternate pathway; Glycoprotein; Hydrolase; Immune response; Innate immunity; Protease; Repeat; Secreted; Serine protease; Signal; Sushi; Zymogen.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    22  22     By similarity. 
CHAIN   23   761  739     Complement factor B. PRO_0000027548
CHAIN   23   256  234     Complement factor B Ba fragment. PRO_0000027549
CHAIN   257   761  505     Complement factor B Bb fragment. PRO_0000027550
DOMAIN   32    97  66     Sushi 1. 
DOMAIN   98   157  60     Sushi 2. 
DOMAIN   160   217  58     Sushi 3. 
DOMAIN   267   466  200     VWFA. 
DOMAIN   474   754  281     Peptidase S1. 
ACT_SITE   523   523        Charge relay system. 
ACT_SITE   573   573        Charge relay system. 
ACT_SITE   696   696        Charge relay system. 
CARBOHYD   119   119        N-linked (GlcNAc...). 
CARBOHYD   139   139        N-linked (GlcNAc...) (Potential). 
CARBOHYD   282   282        N-linked (GlcNAc...). 
CARBOHYD   375   375        N-linked (GlcNAc...) (Potential). 
DISULFID   34    73        By similarity. 
DISULFID   59    95        By similarity. 
DISULFID   100   142        By similarity. 
DISULFID   128   155        By similarity. 
DISULFID   162   202        By similarity. 
DISULFID   188   215        By similarity. 
DISULFID   508   524        By similarity. 
DISULFID   692   722        By similarity. 
CONFLICT   730   730        L -> P (in Ref. 4; AAA39549). 
CONFLICT   745   745        V -> E (in Ref. 4; AAA39549). 
Sequence information
Length: 761 AA [This is the length of the unprocessed precursor] Molecular weight: 85004 Da [This is the MW of the unprocessed precursor] CRC64: 9E9015448A61020E [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MESPQLCLVL LVLGFSSGGV SATPVLEARP QVSCSLEGVE IKGGSFQLLQ GGQALEYLCP 

        70         80         90        100        110        120 
SGFYPYPVQT RTCRSTGSWS DLQTRDQKIV QKAECRAIRC PRPQDFENGE FWPRSPFYNL 

       130        140        150        160        170        180 
SDQISFQCYD GYVLRGSANR TCQENGRWDG QTAICDDGAG YCPNPGIPIG TRKVGSQYRL 

       190        200        210        220        230        240 
EDIVTYHCSR GLVLRGSQKR KCQEGGSWSG TEPSCQDSFM YDSPQEVAEA FLSSLTETIE 

       250        260        270        280        290        300 
GADAEDGHSP GEQQKRKIVL DPSGSMNIYL VLDGSDSIGS SNFTGAKRCL TNLIEKVASY 

       310        320        330        340        350        360 
GVRPRYGLLT YATVPKVLVR VSDERSSDAD WVTEKLNQIS YEDHKLKSGT NTKRALQAVY 

       370        380        390        400        410        420 
SMMSWAGDAP PEGWNRTRHV IIIMTDGLHN MGGNPVTVIQ DIRALLDIGR DPKNPREDYL 

       430        440        450        460        470        480 
DVYVFGVGPL VDSVNINALA SKKDNEHHVF KVKDMEDLEN VFYQMIDETK SLSLCGMVWE 

       490        500        510        520        530        540 
HKKGNDYHKQ PWQAKISVTR PLKGHETCMG AVVSEYFVLT AAHCFMVDDQ KHSIKVSVGG 

       550        560        570        580        590        600 
QRRDLEIEEV LFHPKYNING KKAEGIPEFY DYDVALVKLK NKLKYGQTLR PICLPCTEGT 

       610        620        630        640        650        660 
TRALRLPQTA TCKQHKEQLL PVKDVKALFV SEQGKSLTRK EVYIKNGDKK ASCERDATKA 

       670        680        690        700        710        720 
QGYEKVKDAS EVVTPRFLCT GGVDPYADPN TCKGDSGGPL IVHKRSRFIQ VGVISWGVVD 

       730        740        750        760 
VCRDQRRQQL VPSYARDFHI NLFQVLPWLK DKLKDEDLGF L
P04186 in FASTA format

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