ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry P04185

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name UROK_PIG
Primary accession number P04185
Secondary accession numbers None
Integrated into Swiss-Prot on March 20, 1987
Sequence was last modified on August 13, 1987 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 79)
Name and origin of the protein
Protein name Urokinase-type plasminogen activator [Precursor]
Synonyms uPA
U-plasminogen activator
EC 3.4.21.73
Contains Urokinase-type plasminogen activator long chain A
Urokinase-type plasminogen activator short chain A
Urokinase-type plasminogen activator chain B
Gene name
Name: PLAU
From
Sus scrofa (Pig) [TaxID: 9823] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; Sus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
TISSUE=Kidney;
DOI=10.1093/nar/12.24.9525; PubMed=6096832 [NCBI, ExPASy, EBI, Israel, Japan]
Nagamine Y., Pearson D., Altus M.S., Reich E.;
"cDNA and gene nucleotide sequence of porcine plasminogen activator.";
Nucleic Acids Res. 12:9525-9541(1984).
[2]
 SEQUENCE REVISION TO 241.
Nagamine Y.;
Submitted (DEC-1986) to the PIR data bank.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X01648; CAA25806.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X02724; CAA26511.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A00932; UKPG.
RefSeq NP_999110.1; -.
UniGene Ssc.11194
3D structure databases
HSSP P00749; 1KDU. [HSSP ENTRY / PDB]
SMR P04185; 31-154, 190-433.
ModBase P04185.
Protein family/group databases
MEROPS S01.231; -.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR000742; EGF_3.
IPR013111; EGF_extracell.
IPR013032; EGF_like_reg_CS.
IPR000001; Kringle.
IPR001254; Peptidase_S1_S6.
IPR001314; Peptidase_S1A.
Graphical view of domain structure.
Gene3D G3DSA:2.40.20.10; Kringle; 1.
Pfam PF07974; EGF_2; 1.
PF00051; Kringle; 1.
PF00089; Trypsin; 1.
Pfam graphical view of domain structure.
PRINTS PR00722; CHYMOTRYPSIN.
PR00018; KRINGLE.
ProDom PD000395; Kringle; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00130; KR; 1.
SM00020; Tryp_SPc; 1.
SMART graphical view of domain structure.
PROSITE PS00022; EGF_1; 1.
PS01186; EGF_2; FALSE_NEG.
PS50026; EGF_3; 1.
PS00021; KRINGLE_1; 1.
PS50070; KRINGLE_2; 1.
PS50240; TRYPSIN_DOM; 1.
PS00134; TRYPSIN_HIS; 1.
PS00135; TRYPSIN_SER; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P04185.
ProtoNet P04185.
Genome annotation databases
GeneID 396985; -.
KEGG ssc:396985; -.
Phylogenomic databases
HOVERGEN P04185; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
EGF-like domain; Glycoprotein; Hydrolase; Kringle; Plasminogen activation; Protease; Secreted; Serine protease; Signal; Zymogen.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    20  20     By similarity. 
CHAIN   21   442  422     Urokinase-type plasminogen activator. PRO_0000028330
CHAIN   21   188  168     Urokinase-type plasminogen activator long chain A (By similarity). PRO_0000028331
CHAIN   167   188  22     Urokinase-type plasminogen activator short chain A (By similarity). PRO_0000285900
CHAIN   190   442  253     Urokinase-type plasminogen activator chain B (By similarity). PRO_0000028332
DOMAIN   29    65  37     EGF-like. 
DOMAIN   72   153  82     Kringle. 
DOMAIN   190   435  246     Peptidase S1. 
REGION   36    59  24     Binds urokinase plasminogen activator surface receptor (By similarity). 
REGION   154   189  36     Connecting peptide. 
ACT_SITE   235   235        Charge relay system. 
ACT_SITE   286   286        Charge relay system. 
ACT_SITE   387   387        Charge relay system. 
CARBOHYD   152   152        N-linked (GlcNAc...) (Potential). 
DISULFID   33    41        By similarity. 
DISULFID   35    53        By similarity. 
DISULFID   55    64        By similarity. 
DISULFID   72   153        By similarity. 
DISULFID   93   135        By similarity. 
DISULFID   124   148        By similarity. 
DISULFID   179   310        Interchain (between A and B chains) (By similarity). 
DISULFID   220   236        By similarity. 
DISULFID   228   299        By similarity. 
DISULFID   324   393        By similarity. 
DISULFID   356   372        By similarity. 
DISULFID   383   411        By similarity. 
CONFLICT   241   241        Q -> H (in Ref. 1; CAA25806). 
CONFLICT   242   242        Q -> H (in Ref. 1; CAA26511). 
CONFLICT   288   288        A -> GS (in Ref. 1; CAA25806). 
Sequence information
Length: 442 AA [This is the length of the unprocessed precursor] Molecular weight: 49117 Da [This is the MW of the unprocessed precursor] CRC64: EE32FCEF501321EE [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MRVLRACLSL CVLVVSDSKG SHELHQESGA SNCGCLNGGK CVSYKYFSNI QRCSCPKKFQ 

        70         80         90        100        110        120 
GEHCEIDTSQ TCFEGNGHSY RGKANTNTGG RPCLPWNSAT VLLNTYHAHR PDALQLGLGK 

       130        140        150        160        170        180 
HNYCRNPDNQ RRPWCYVQVG LKQLVQECMV PNCSGGESHR PAYDGKNPFS TPEKVEFQCG 

       190        200        210        220        230        240 
QKALRPRFKI VGGKSTTIEN QPWFAAIYRR HRGGSVTYVC GGSLISPCWV VSATHCFINY 

       250        260        270        280        290        300 
QQKEDYIVYL GRQTLHSSTH GEMKFEVEKL ILHEDYSADS LAHHNDIALL KIRTDKGQCA 

       310        320        330        340        350        360 
QPSRSIQTIC LPPVNGDAHF GASCEIVGFG KEDPSDYLYP EQLKMTVVKL VSHRECQQPH 

       370        380        390        400        410        420 
YYGSEVTTKM LCAADPQWKT DSCQGDSGGP LVCSTQGRLT LTGIVSWGRE CAMKDKPGVY 

       430        440 
TRVSRFLTWI HTHVGGENGL AH
P04185 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA) 		Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Hosted by ch flag SIB Switzerland Mirror sites: Australia Brazil Canada China Korea
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!