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UniProtKB/Swiss-Prot entry P03953


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CFAD_MOUSE
Primary accession number P03953
Secondary accession number Q61280
Integrated into Swiss-Prot on October 23, 1986
Sequence was last modified on October 23, 1986 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 88)
Name and origin of the protein
Protein name Complement factor D [Precursor]
Synonyms EC 3.4.21.46
C3 convertase activator
Properdin factor D
Adipsin
28 kDa adipocyte protein
Gene name
Name: Cfd
Synonyms: Adn, Df
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=3015943 [NCBI, ExPASy, EBI, Israel, Japan]
Phillips M., Djian P., Green H.;
"The nucleotide sequence of three genes participating in the adipose differentiation of 3T3 cells.";
J. Biol. Chem. 261:10821-10827(1986).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2).
DOI=10.1093/nar/14.22.8879; PubMed=3024123 [NCBI, ExPASy, EBI, Israel, Japan]
Min H.Y., Spiegelman B.M.;
"Adipsin, the adipocyte serine protease: gene structure and control of expression by tumor necrosis factor.";
Nucleic Acids Res. 14:8879-8892(1986).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Swiss white;
PubMed=3901003 [NCBI, ExPASy, EBI, Israel, Japan]
Cook K.S., Groves D.L., Min H.Y., Spiegelman B.M.;
"A developmentally regulated mRNA from 3T3 adipocytes encodes a novel serine protease homologue.";
Proc. Natl. Acad. Sci. U.S.A. 82:6480-6484(1985).
[4]
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-124, AND MASS SPECTROMETRY.
TISSUE=Plasma;
DOI=10.1021/pr060186m; PubMed=16944957 [NCBI, ExPASy, EBI, Israel, Japan]
Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.;
"Proteome-wide characterization of N-glycosylation events by diagonal chromatography.";
J. Proteome Res. 5:2438-2447(2006).
[5]
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-176, AND MASS SPECTROMETRY.
TISSUE=Plasma;
DOI=10.1021/pr0604559; PubMed=17330941 [NCBI, ExPASy, EBI, Israel, Japan]
Bernhard O.K., Kapp E.A., Simpson R.J.;
"Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides.";
J. Proteome Res. 6:987-995(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M11768; AAA40486.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X04673; CAA28378.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X04673; CAA28379.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M13386; AAA37262.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR C25952; WMMS28.
RefSeq NP_038487.1; -.
UniGene Mm.4407
3D structure databases
HSSP P00746; 1FDP. [HSSP ENTRY / PDB]
ModBase P03953.
Protein family/group databases
MEROPS S01.191; -.
Organism-specific databases
MGI MGI:87931; Cfd.
Gene expression databases
ArrayExpress P03953; -.
CleanEx MM_CFD; -.
GermOnline ENSMUSG00000061780; Mus musculus.
Ontologies
GO
GO:0005615; Cellular component: extracellular space (inferred from direct assay from MGI).
QuickGo view.
Family and domain databases
InterPro IPR001254; Peptidase_S1_S6.
IPR001314; Peptidase_S1A.
Graphical view of domain structure.
Pfam PF00089; Trypsin; 1.
Pfam graphical view of domain structure.
PRINTS PR00722; CHYMOTRYPSIN.
SMART SM00020; Tryp_SPc; 1.
SMART graphical view of domain structure.
PROSITE PS50240; TRYPSIN_DOM; 1.
PS00134; TRYPSIN_HIS; 1.
PS00135; TRYPSIN_SER; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P03953.
ProtoNet P03953.
Genome annotation databases
Ensembl ENSMUSG00000061780; Mus musculus. [Contig view]
GeneID 11537; -.
KEGG mmu:11537; -.
Phylogenomic databases
HOGENOM P03953; -.
HOVERGEN P03953; -.
Other
NextBio 278986; -.
SOURCE Cfd; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Complement alternate pathway; Glycoprotein; Hydrolase; Immune response; Innate immunity; Protease; Secreted; Serine protease; Signal; Zymogen.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    20  20     Potential. 
PROPEP   21    25  5     Activation peptide (Potential). PRO_0000027562
CHAIN   26   259  234     Complement factor D. PRO_0000027563
DOMAIN   26   254  229     Peptidase S1. 
ACT_SITE   66    66        Charge relay system. 
ACT_SITE   115   115        Charge relay system. 
ACT_SITE   209   209        Charge relay system. 
CARBOHYD   46    46        N-linked (GlcNAc...) (Potential). 
CARBOHYD   124   124        N-linked (GlcNAc...). 
CARBOHYD   176   176        N-linked (GlcNAc...). 
CARBOHYD   251   251        N-linked (GlcNAc...) (Potential). 
CARBOHYD   256   256        N-linked (GlcNAc...) (Potential). 
DISULFID   51    67        By similarity. 
DISULFID   149   215        By similarity. 
DISULFID   180   196        By similarity. 
DISULFID   205   230        By similarity. 
VAR_SEQ   20    20        Missing (in isoform 2). VSP_005382
Sequence information
Length: 259 AA [This is the length of the unprocessed precursor] Molecular weight: 28057 Da [This is the MW of the unprocessed precursor] CRC64: 8C3A952561247DF9 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MHSSVYFVAL VILGAAVCAA QPRGRILGGQ EAAAHARPYM ASVQVNGTHV CGGTLLDEQW 

        70         80         90        100        110        120 
VLSAAHCMDG VTDDDSVQVL LGAHSLSAPE PYKRWYDVQS VVPHPGSRPD SLEDDLILFK 

       130        140        150        160        170        180 
LSQNASLGPH VRPLPLQYED KEVEPGTLCD VAGWGVVTHA GRRPDVLHQL RVSIMNRTTC 

       190        200        210        220        230        240 
NLRTYHDGVV TINMMCAESN RRDTCRGDSG SPLVCGDAVE GVVTWGSRVC GNGKKPGVYT 

       250 
RVSSYRMWIE NITNGNMTS 

P03953 in FASTA format

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