[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING. STRAIN=Bristol N2; DOI=10.1126/science.282.5396.2012; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan] The C. elegans sequencing consortium; "Genome sequence of the nematode C. elegans: a platform for investigating biology."; Science 282:2012-2018(1998).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 150-706. PubMed=3457381 [NCBI, ExPASy, EBI, Israel, Japan] Goddard J.M., Weiland J.J., Capecchi M.R.; "Isolation and characterization of Caenorhabditis elegans DNA sequences homologous to the v-abl oncogene."; Proc. Natl. Acad. Sci. U.S.A. 83:2172-2176(1986).

Comments

CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

ALTERNATIVE PRODUCTS: 3 named isoforms [FASTA] produced by alternative splicing. Experimental confirmation may be lacking for some isoforms.

Name	a
Isoform ID	P03949-1
This is the isoform sequence displayed in this entry.

Name	b
Isoform ID	P03949-2
Features which should be applied to build the isoform sequence: VSP_004963.

Name	c
Isoform ID	P03949-3
Features which should be applied to build the isoform sequence: VSP_004962.

SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily.
SIMILARITY: Contains 1 protein kinase domain.
SIMILARITY: Contains 1 SH2 domain.
SIMILARITY: Contains 1 SH3 domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

Z50806; CAA90691.2; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
Z50806; CAB60296.2; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
Z50806; CAB60297.2; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M13235; AAA28129.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

T23832; T23832.

NP_509778.2; -.

3D structure databases

HSSP

Q61258; 1FPU. [HSSP ENTRY / PDB]

ModBase

P03949.

Organism-specific databases

WormBase

WBGene00000018; abl-1.

WormPep

M79.1a; CE31570. [WormPep / WorfDB]
M79.1b; CE31571. [WormPep / WorfDB]
M79.1c; CE31572. [WormPep / WorfDB]

Gene expression databases

ArrayExpress

P03949; -.

Ontologies

GO:0000077;	Biological process: DNA damage checkpoint (inferred from genetic interaction from WormBase).
GO:0043066;	Biological process: negative regulation of apoptosis (inferred from genetic interaction from WormBase).
GO:0043518;	Biological process: negative regulation of DNA damage response, signal transduction by p53 class mediator (inferred from genetic interaction from WormBase).
GO:0010212;	Biological process: response to ionizing radiation (inferred from mutant phenotype from WormBase).
QuickGo view.

Family and domain databases

InterPro

IPR015015; F_actin_bd.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR000980; SH2.
IPR001452; SH3.
IPR001245; Tyr_pkinase.
IPR008266; Tyr_pkinase_AS.
Graphical view of domain structure.

Gene3D

G3DSA:3.30.505.10; SH2; 1.

Pfam

PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
Pfam graphical view of domain structure.

PRINTS

PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.

ProDom

PD000001; Prot_kinase; 1.
PD000093; SH2; 1.
PD000066; SH3; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00808; FABD; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
SMART graphical view of domain structure.

PROSITE

PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PROSITE graphical view of domain structure (profiles).

Genome annotation databases

Ensembl

M79.1; Caenorhabditis elegans. [Contig view]

GeneID

181261; -.

Other

NextBio

913152; -.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Alternative splicing; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; SH2 domain; SH3 domain; Transferase; Tyrosine-protein kinase.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 1224`	`1224`	`Tyrosine-protein kinase abl-1.`	`PRO_0000088055`
`DOMAIN`	`115 188`	`74`	`SH3.`
`DOMAIN`	`194 284`	`91`	`SH2.`
`DOMAIN`	`311 562`	`252`	`Protein kinase.`
`NP_BIND`	`317 325`	`9`	`ATP (By similarity).`
`ACT_SITE`	`432 432`		`Proton acceptor (By similarity).`
`BINDING`	`340 340`		`ATP (By similarity).`
`VAR_SEQ`	`1 88`		`MGHSHSTGKEINDNELFTCEDPVFDQPVASPKSEISSKLA` `EEIERSKSPLILEVSPRTPDSVQMFRPTFDTFRPPNSDSS` `TFRGSQSR -> MIMNPCFRERSQKRTKKRAKNRAKSRSTMYLSKVGDSSLA` `MSRSLPSVALPMHYLHHKLAESICFITATIDSL (in isoform c).`	`VSP_004962`
`VAR_SEQ`	`54 63`		`Missing (in isoform b).`	`VSP_004963`

Sequence information

Length: 1224 AA [This is the length of the unprocessed precursor]

Molecular weight: 138326 Da [This is the MW of the unprocessed precursor]

CRC64: 56D8513DD2061071 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGHSHSTGKE INDNELFTCE DPVFDQPVAS PKSEISSKLA EEIERSKSPL ILEVSPRTPD 

        70         80         90        100        110        120 
SVQMFRPTFD TFRPPNSDSS TFRGSQSRED LVACSSMNSV NNVHDMNTVS SSSSSSAPLF 

       130        140        150        160        170        180 
VALYDFHGVG EEQLSLRKGD QVRILGYNKN NEWCEARLYS TRKNDASNQR RLGEIGWVPS 

       190        200        210        220        230        240 
NFIAPYNSLD KYTWYHGKIS RSDSEAILGS GITGSFLVRE SETSIGQYTI SVRHDGRVFH 

       250        260        270        280        290        300 
YRINVDNTEK MFITQEVKFR TLGELVHHHS VHADGLICLL MYPASKKDKG RGLFSLSPNA 

       310        320        330        340        350        360 
PDEWELDRSE IIMHNKLGGG QYGDVYEGYW KRHDCTIAVK ALKEDAMPLH EFLAEAAIMK 

       370        380        390        400        410        420 
DLHHKNLVRL LGVCTHEAPF YIITEFMCNG NLLEYLRRTD KSLLPPIILV QMASQIASGM 

       430        440        450        460        470        480 
SYLEARHFIH RDLAARNCLV SEHNIVKIAD FGLARFMKED TYTAHAGAKF PIKWTAPEGL 

       490        500        510        520        530        540 
AFNTFSSKSD VWAFGVLLWE IATYGMAPYP GVELSNVYGL LENGFRMDGP QGCPPSVYRL 

       550        560        570        580        590        600 
MLQCWNWSPS DRPRFRDIHF NLENLISSNS LNDEVQKQLK KNNDKKLESD KRRSNVRERS 

       610        620        630        640        650        660 
DSKSRHSSHH DRDRDRESLH SRNSNPEIPN RSFIRTDDSV SFFNPSTTSK VTSFRAQGPP 

       670        680        690        700        710        720 
FPPPPQQNTK PKLLKSVLNS NARHASEEFE RNEQDDVVPL AEKNVRKAVT RLGGTMPKGQ 

       730        740        750        760        770        780 
RIDAYLDSMR RVDSWKESTD ADNEGAGSSS LSRTVSNDSL DTLPLPDSMN SSTYVKMHPA 

       790        800        810        820        830        840 
SGENVFLRQI RSKLKKRSET PELDHIDSDT ADETTKSEKS PFGSLNKSSI KYPIKNAPEF 

       850        860        870        880        890        900 
SENHSRVSPV PVPPSRNASV SVRPDSKAED SSDETTKDVG MWGPKHAVTR KIEIVKNDSY 

       910        920        930        940        950        960 
PNVEGELKAK IRNLRHVPKE ESNTSSQEDL PLDATDNTND SIIVIPRDEK AKVRQLVTQK 

       970        980        990       1000       1010       1020 
VSPLQHHRPF SLQCPNNSTS SAISHSEHAD SSETSSLSGV YEERMKPELP RKRSNGDTKV 

      1030       1040       1050       1060       1070       1080 
VPVTWIINGE KEPNGMARTK SLRDITSKFE QLGTASTIES KIEEAVPYRE HALEKKGTSK 

      1090       1100       1110       1120       1130       1140 
RFSMLEGSNE LKHVVPPRKN RNQDESGSID EEPVSKDMIV SLLKVIQKEF VNLFNLASSE 

      1150       1160       1170       1180       1190       1200 
ITDEKLQQFV IMADNVQKLH STCSVYAEQI SPHSKFRFKE LLSQLEIYNR QIKFSHNPRA 

      1210       1220 
KPVDDKLKMA FQDCFDQIMR LVDR

P03949 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools