ID   ORF2A_AMVLE             Reviewed;         790 AA.
AC   P03593;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 2.
DT   04-NOV-2008, entry version 37.
DE   RecName: Full=RNA-directed RNA polymerase 2A;
DE            Short=protein 2A;
DE            EC=2.7.7.48;
GN   Name=RNA2; ORFNames=ORF2a;
OS   Alfalfa mosaic virus (strain 425 / isolate Leiden).
OC   Viruses; ssRNA positive-strand viruses, no DNA stage; Bromoviridae;
OC   Alfamovirus.
OX   NCBI_TaxID=12322;
OH   NCBI_TaxID=4045; Apium graveolens (Celery).
OH   NCBI_TaxID=83862; Astragalus glycyphyllos (Wild liquorice).
OH   NCBI_TaxID=4072; Capsicum annuum (Bell pepper).
OH   NCBI_TaxID=41386; Caryopteris incana.
OH   NCBI_TaxID=3827; Cicer arietinum (Chickpea) (Garbanzo).
OH   NCBI_TaxID=35936; Dolichos lab lab (Field bean) (Lablab purpureus).
OH   NCBI_TaxID=3847; Glycine max (Soybean).
OH   NCBI_TaxID=4236; Lactuca sativa (Garden lettuce).
OH   NCBI_TaxID=3864; Lens culinaris (Lentil) (Cicer lens).
OH   NCBI_TaxID=3869; Lupinus.
OH   NCBI_TaxID=145753; Malva parviflora (Little mallow) (Cheeseweed mallow).
OH   NCBI_TaxID=3879; Medicago sativa (Alfalfa).
OH   NCBI_TaxID=4097; Nicotiana tabacum (Common tobacco).
OH   NCBI_TaxID=3916; Phaseolus aureus (Mung bean) (Vigna radiata).
OH   NCBI_TaxID=3885; Phaseolus vulgaris (Kidney bean) (French bean).
OH   NCBI_TaxID=23113; Philadelphus.
OH   NCBI_TaxID=3888; Pisum sativum (Garden pea).
OH   NCBI_TaxID=4081; Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OH   NCBI_TaxID=4113; Solanum tuberosum (Potato).
OH   NCBI_TaxID=157662; Teramnus repens.
OH   NCBI_TaxID=60916; Trifolium incarnatum (Crimson clover).
OH   NCBI_TaxID=85293; Viburnum opulus (Guelder-rose).
OH   NCBI_TaxID=3917; Vigna unguiculata (Cowpea).
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=83220723; PubMed=6304618; DOI=10.1093/nar/11.10.3019;
RA   Cornelissen B.J.C., Brederode F.T., Veeneman G.H., van Boom J.H.,
RA   Bol J.F.;
RT   "Complete nucleotide sequence of alfalfa mosaic virus RNA 2.";
RL   Nucleic Acids Res. 11:3019-3025(1983).
CC   -!- FUNCTION: RNA-directed RNA polymerase.
CC   -!- CATALYTIC ACTIVITY: Nucleoside triphosphate + RNA(n) = diphosphate
CC       + RNA(n+1).
CC   -!- MISCELLANEOUS: The virus has a tripartite genome (RNA1, RNA2 and
CC       RNA3) and an encapsidated subgenomic RNA (RNA4) from which the
CC       coat protein is expressed.
CC   -!- SIMILARITY: Contains 1 RdRp catalytic domain.
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DR   EMBL; X01572; CAA25728.1; -; Unassigned_RNA.
DR   PIR; A04201; WMFM9.
DR   RefSeq; YP_053235.1; -.
DR   GeneID; 962668; -.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0006410; P:transcription, RNA-dependent; IEA:UniProtKB-KW.
DR   InterPro; IPR001788; RNA-dep_RNA_pol_vir-typ.
DR   InterPro; IPR007094; RNA_pol_PSvir.
DR   Pfam; PF00978; RdRP_2; 1.
DR   PROSITE; PS50507; RDRP_SSRNA_POS; 1.
PE   4: Predicted;
KW   Nucleotide-binding; Nucleotidyltransferase; RNA replication;
KW   RNA-directed RNA polymerase; Transferase.
FT   CHAIN         1    790       RNA-directed RNA polymerase 2A.
FT                                /FTId=PRO_0000083267.
FT   DOMAIN      524    639       RdRp catalytic.
SQ   SEQUENCE   790 AA;  89855 MW;  B435C9EB9AA853C2 CRC64;
     MFTLLRCLGF GVNEPTNTSS SEYVPEYSVE EISNEVAELD SVDPLFQCYK HVFVSLMLVR
     KMTQAAEDFL ESFGGEFDSP CCRVYRLYRH FVNEDDAPAW AIPNVVNEDS YDDYAYLREE
     LDAIDSSFEL LNEERELSEI TDRLNALRFF PVSKTEALPV ANVQEVKLIS ETYQLLMTFI
     NYSDENIPSE MPAPLLDELG MLPEELGPLN EIEDIKPVAA PITLLSEFRA SDNAKPLDIV
     EIIPDVSPTK PYEAVISGND WMTLGRIIPT TPVPTIRDVF FSGLSRHGSP EVIQNALDEF
     LPLHHSIDDK YFQEWVETSD KSLDVDPCRI DLSVFNNWQS SENCYEPRFK TGALSTRKGT
     QTEALLAIKK RNMNVPNLGQ IYDVNSVANS VVNKLLTTVI DPDKLCMFPD FISEGEVSYF
     QDYIVGKNPD PELYSDPLGV RSIDSYKHMI KSVLKPVEDN SLHLERPMPA TITYHDKDIV
     MSSSPIFLAA AARLMLILRD KITIPSGKFH QLFSIDAEAF DASFHFKEID FSKFDKSQNE
     LHHLIQERFL KYLGIPNEFL TLWFNAHRKS RISDSKNGVF FNVDFQRRTG DALTYLGNTI
     VTLACLCHVY DLMDPNVKFV VASGDDSLIG TVEELPRDQE FLFTTLFNLE AKFPHNQPFI
     CSKFLITMPT TSGGKVVLPI PNPLKLLIRL GSKKVNADIF DEWYQSWIDI IGGFNDHHVI
     RCVAAMTAHR YLRRPSLYLE AALESLGKIF AGKTLCKECL FNEKHESNVK IKPRRVKKSH
     SDARSRARRA
//