NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=A;
PubMed=6090694 [NCBI, ExPASy, EBI, Israel, Japan]
Wilhelmsen K.C., Eggleton K., Temin H.M.;
"Nucleic acid sequences of the oncogene v-rel in reticuloendotheliosis virus strain T and its cellular homolog, the proto-oncogene c-rel.";
J. Virol. 52:172-182(1984).

Comments

FUNCTION: During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.
CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
CATALYTIC ACTIVITY: Endonucleolytic cleavage to 5'-phosphomonoester.
PTM: Specific enzymatic cleavages in vivo yield mature proteins.
MISCELLANEOUS: Strain A is a helper virus of the strain T.
SIMILARITY: Belongs to the retroviral Pol polyprotein family.
SIMILARITY: Contains 1 integrase catalytic domain.
SIMILARITY: Contains 1 RNase H domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X01455; CAA25685.1; -; Genomic_RNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

A03959; A03959.

3D structure databases

HSSP

P03354; 1CXQ. [HSSP ENTRY / PDB]

ModBase

P03360.

Protein family/group databases

MEROPS

A02.008; -.

Ontologies

GO:0003887;	Molecular function: DNA-directed DNA polymerase activity (inferred from electronic annotation from EC).
GO:0003964;	Molecular function: RNA-directed DNA polymerase activity (inferred from electronic annotation from UniProtKB-KW).
GO:0006310;	Biological process: DNA recombination (inferred from electronic annotation from UniProtKB-KW).
GO:0032196;	Biological process: transposition (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR001584; Integrase_cat-core.
IPR002156; RNase_H.
Graphical view of domain structure.

Pfam

PF00075; RnaseH; 1.
PF00665; rve; 1.
Pfam graphical view of domain structure.

PROSITE

PS50994; INTEGRASE; 1.
PS50879; RNASE_H; 1.
PROSITE graphical view of domain structure (profiles).

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

DNA integration; DNA recombination; Endonuclease; Hydrolase; Multifunctional enzyme; Nuclease; Nucleotidyltransferase; RNA-directed DNA polymerase; Transferase.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`<1 473`	`>473`	`Pol polyprotein.`	`PRO_0000125480`
`DOMAIN`	`<1 62`	`>62`	`RNase H.`
`DOMAIN`	`184 360`	`177`	`Integrase catalytic.`
`NON_TER`	`1 1`

Sequence information

Length: 473 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 52212 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: 89F62FA489EF51DD [This is a checksum on the sequence]

        10         20         30         40         50         60 
KGELLTAGEK AIKNAPEILA LLTAVWLPKR VAVMHCKGHQ KDDAPTSTGN RRADEVAREV 

        70         80         90        100        110        120 
AIRPLSTQAT ISDAPDMPDT ETPQYSHVEE ALGHRLRGTK DSAGWWHLPD GRLLLPRAVG 

       130        140        150        160        170        180 
RKVLEQTHRA THLGESKLTE LVRKHYPICG IYRAARDITT RCVACAQVNP RAAPVEKGLN 

       190        200        210        220        230        240 
SRIRGAAPGE HWEVDFTEMI TAKGGYKYLL VLVDTFSGWV EAYPAKRETS QVVIKHLILD 

       250        260        270        280        290        300 
IIPRFGLPVQ IGSDNGPAFV AKVTQQLCEA LNVSWKLHCA YRPQSSGQVE RMNRTLKKAI 

       310        320        330        340        350        360 
AKLEDRDRRG LGLPPPSGFA PGTVYPGREG LSPFEILYGL KPPVVPRVGC DKLASITNQT 

       370        380        390        400        410        420 
LLKSLQALQA TRSLARAAAR PTAPERSSAR PYPTVPNLVT SFFVKKHDFQ QLGPRWDGPY 

       430        440        450        460        470 
TVVLSTPTAV KAAGKTPWIH YSRLKKAPDN QEEWTVSPTS DPLRVKLTRR AKP

P03360 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools