[1]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=205947 [NCBI, ExPASy, EBI, Israel, Japan]
Reddy V.B.,
Thimmappaya B.,
Dhar R.,
Subramanian K.N.,
Zain B.S.,
Pan J.,
Ghosh P.K.,
Celma M.L.,
Weissman S.M.;
"The genome of simian virus 40.";
Science 200:494-502(1978).
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[2]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND ACETYLATION AT MET-1.
STRAIN=776;
DOI=10.1038/273113a0; PubMed=205802 [NCBI, ExPASy, EBI, Israel, Japan]
Fiers W.,
Contreras R.,
Haegeman G.,
Rogiers R.,
van de Voorde A.,
van Heuverswyn H.,
van Herreweghe J.,
Volckaert G.,
Ysebaert M.;
"Complete nucleotide sequence of SV40 DNA.";
Nature 273:113-120(1978).
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[3]
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NUCLEAR LOCALIZATION SIGNAL.
DOI=10.1016/0092-8674(84)90457-4; PubMed=6096007 [NCBI, ExPASy, EBI, Israel, Japan]
Kalderon D.,
Roberts B.L.,
Richardson W.D.,
Smith A.E.;
"A short amino acid sequence able to specify nuclear location.";
Cell 39:499-509(1984).
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[4]
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ZINC-FINGER DOMAIN.
PubMed=2173794 [NCBI, ExPASy, EBI, Israel, Japan]
Hoess A.,
Moarefi I.F.,
Fanning E.,
Arthur A.K.;
"The finger domain of simian virus 40 large T antigen controls DNA-binding specificity.";
J. Virol. 64:6291-6296(1990).
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[5]
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ZINC-FINGER DOMAIN.
PubMed=1851875 [NCBI, ExPASy, EBI, Israel, Japan]
Loeber G.,
Stenger J.E.,
Ray S.,
Parsons R.E.,
Anderson M.E.,
Tegtmeyer P.;
"The zinc finger region of simian virus 40 large T antigen is needed for hexamer assembly and origin melting.";
J. Virol. 65:3167-3174(1991).
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[6]
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ASSOCIATION WITH HOST RB PROTEIN.
DOI=10.1016/0092-8674(88)90559-4; PubMed=2839300 [NCBI, ExPASy, EBI, Israel, Japan]
Decaprio J.A.,
Ludlow J.W.,
Figge J.,
Shew J.-Y.,
Huang C.-M.,
Lee W.-H.,
Marsilio E.,
Paucha E.,
Livingston D.M.;
"SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene.";
Cell 54:275-283(1988).
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[7]
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IN VITRO PHOSPHORYLATION.
DOI=10.1016/0042-6822(88)90653-8; PubMed=2838952 [NCBI, ExPASy, EBI, Israel, Japan]
Graesser F.A.,
Scheidmann K.H.,
Tuazon P.T.,
Traugh J.A.,
Walter G.;
"In vitro phosphorylation of SV40 large T antigen.";
Virology 165:13-22(1988).
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[8]
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PROTEIN SEQUENCE OF 102-118, AND PHOSPHORYLATION AT THR-124 BY CDC2.
DOI=10.1038/341503a0; PubMed=2552322 [NCBI, ExPASy, EBI, Israel, Japan]
McVey D.,
Brizuela L.,
Mohr I.,
Marshak D.R.,
Gluzman Y.,
Beach D.;
"Phosphorylation of large tumour antigen by cdc2 stimulates SV40 DNA replication.";
Nature 341:503-507(1989).
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[9]
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IN VITRO ACTIVATION OF DNA REPLICATION BY PP2A.
PubMed=2555176 [NCBI, ExPASy, EBI, Israel, Japan]
Virshup D.M.,
Kauffman M.G.,
Kelly T.J.;
"Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A.";
EMBO J. 8:3891-3898(1989).
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[10]
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REGULATION OF REPLICATION BY PHOSPHORYLATION.
DOI=10.1016/0092-8674(90)90179-I; PubMed=2160857 [NCBI, ExPASy, EBI, Israel, Japan]
Prives C.;
"The replication functions of SV40 T antigen are regulated by phosphorylation.";
Cell 61:735-738(1990).
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[11]
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DEPHOSPHORYLATION BY HOST PP2A.
PubMed=1848668 [NCBI, ExPASy, EBI, Israel, Japan]
Scheidtmann K.H.,
Mumby M.C.,
Rundell K.,
Walter G.;
"Dephosphorylation of simian virus 40 large-T antigen and p53 protein by protein phosphatase 2A: inhibition by small-t antigen.";
Mol. Cell. Biol. 11:1996-2003(1991).
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[12]
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SITES OF DEPHOSPHORYLATION BY HOST PP2A.
PubMed=1848320 [NCBI, ExPASy, EBI, Israel, Japan]
Scheidtmann K.H.,
Virshup D.M.,
Kelly T.J.;
"Protein phosphatase 2A dephosphorylates simian virus 40 large T antigen specifically at residues involved in regulation of DNA-binding activity.";
J. Virol. 65:2098-2101(1991).
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[13]
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INTERACTION WITH HUMAN RB1.
PubMed=1316611 [NCBI, ExPASy, EBI, Israel, Japan]
Chellappan S.,
Kraus V.B.,
Kroger B.,
Munger K.,
Howley P.M.,
Phelps W.C.,
Nevins J.R.;
"Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.";
Proc. Natl. Acad. Sci. U.S.A. 89:4549-4553(1992).
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[14]
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ACTIVATION OF REPLICATION BY PHOSPHORYLATION ON THR-124, AND MUTAGENESIS OF THR-124.
PubMed=8648725 [NCBI, ExPASy, EBI, Israel, Japan]
McVey D.,
Woelker B.,
Tegtmeyer P.;
"Mechanisms of simian virus 40 T-antigen activation by phosphorylation of threonine 124.";
J. Virol. 70:3887-3893(1996).
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[15]
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GLYCOSYLATION AT SER-111 AND SER-112, AND MUTAGENESIS OF SER-111 AND SER-112.
DOI=10.1093/glycob/8.4.383; PubMed=9499386 [NCBI, ExPASy, EBI, Israel, Japan]
Medina L.,
Grove K.,
Haltiwanger R.S.;
"SV40 large T antigen is modified with O-linked N-acetylglucosamine but not with other forms of glycosylation.";
Glycobiology 8:383-391(1998).
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[16]
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FUNCTION, AND INTERACTION WITH HOST HDAC1.
DOI=10.1093/nar/gkl1113; PubMed=17341466 [NCBI, ExPASy, EBI, Israel, Japan]
Valls E.,
Blanco-Garcia N.,
Aquizu N.,
Piedra D.,
Estaras C.,
de la Cruz X.,
Martinez-Balbas M.A.;
"Involvement of chromatin and histone deacetylation in SV40 T antigen Transcription; regulation.";
Nucleic Acids Res. 35:1958-1968(2007).
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[17]
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X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 7-117.
DOI=10.1093/emboj/20.1.295; PubMed=11226179 [NCBI, ExPASy, EBI, Israel, Japan]
Kim H.-Y.,
Ahn B.-Y.,
Cho Y.;
"Structural basis for the inactivation of retinoblastoma tumor suppressor by SV40 large T antigen.";
EMBO J. 20:295-304(2001).
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[18]
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X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 260-627.
DOI=10.1038/nature01691; PubMed=12774115 [NCBI, ExPASy, EBI, Israel, Japan]
Li D.,
Zhao R.,
Lilyestrom W.,
Gai D.,
Zhang R.,
DeCaprio J.A.,
Fanning E.,
Jochimiak A.,
Szakonyi G.,
Chen X.S.;
"Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen.";
Nature 423:512-518(2003).
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[19]
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X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 251-627.
DOI=10.1016/j.cell.2004.09.017; PubMed=15454080 [NCBI, ExPASy, EBI, Israel, Japan]
Gai D.,
Zhao R.,
Li D.,
Finkielstein C.V.,
Chen X.S.;
"Mechanisms of conformational change for a replicative hexameric helicase of SV40 large tumor antigen.";
Cell 119:47-60(2004).
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