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UniProtKB/Swiss-Prot entry P02763


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name A1AG1_HUMAN
Primary accession number P02763
Secondary accession number Q8TC16
Integrated into Swiss-Prot on July 21, 1986
Sequence was last modified on January 1, 1988 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 114)
Name and origin of the protein
Protein name Alpha-1-acid glycoprotein 1 [Precursor]
Synonyms AGP 1
Orosomucoid-1
OMD 1
Gene name
Name: ORM1
Synonyms: AGP1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2822385 [NCBI, ExPASy, EBI, Israel, Japan]
Dente L., Pizza M.G., Metspalu A., Cortese R.;
"Structure and expression of the genes coding for human alpha 1-acid glycoprotein.";
EMBO J. 6:2289-2296(1987).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/0378-1119(86)90051-X; PubMed=3770479 [NCBI, ExPASy, EBI, Israel, Japan]
Board P.G., Jones I.M., Bentley A.K.;
"Molecular cloning and nucleotide sequence of human alpha 1 acid glycoprotein cDNA.";
Gene 44:127-131(1986).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1093/nar/13.11.3941; PubMed=2409529 [NCBI, ExPASy, EBI, Israel, Japan]
Dente L., Ciliberto G., Cortese R.;
"Structure of the human alpha 1-acid glycoprotein gene: sequence homology with other human acute phase protein genes.";
Nucleic Acids Res. 13:3941-3952(1985).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-38.
TISSUE=Liver;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
PROTEIN SEQUENCE OF 19-129.
DOI=10.1021/bi00738a026; PubMed=4711474 [NCBI, ExPASy, EBI, Israel, Japan]
Schmid K., Kaufmann H., Isemura S., Bauer F., Emura J., Motoyama T., Ishiguro M., Nanno S.;
"Structure of alpha 1-acid glycoprotein. The complete amino acid sequence, multiple amino acid substitutions, and homology with the immunoglobulins.";
Biochemistry 12:2711-2724(1973).
[6]
PROTEIN SEQUENCE OF 129-201.
DOI=10.1021/bi00770a022; PubMed=4561179 [NCBI, ExPASy, EBI, Israel, Japan]
Ikenaka T., Ishiguro M., Emura J., Kaufmann H., Isemura S., Bauer W., Schmid K.;
"Isolation and partial characterization of the cyanogen bromide fragments of alpha 1-acid glycoprotein and the elucidation of the amino acid sequence of the carboxyl-terminal cyanogen bromide fragment.";
Biochemistry 11:3817-3829(1972).
[7]
DISULFIDE BONDS.
DOI=10.1021/bi00710a006; PubMed=4603214 [NCBI, ExPASy, EBI, Israel, Japan]
Schmid K., Buergi W., Collins J.H., Nanno S.;
"The disulfide bonds of alpha1-acid glycoprotein.";
Biochemistry 13:2694-2697(1974).
[8]
GLYCOSYLATION AT ASN-33; ASN-56; ASN-72; ASN-93 AND ASN-103.
PubMed=1567356 [NCBI, ExPASy, EBI, Israel, Japan]
Treuheit M.J., Costello C.E., Halsall H.B.;
"Analysis of the five glycosylation sites of human alpha 1-acid glycoprotein.";
Biochem. J. 283:105-112(1992).
[9]
GLYCOSYLATION AT ASN-33.
DOI=10.1038/nbt827; PubMed=12754519 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang H., Li X.-J., Martin D.B., Aebersold R.;
"Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.";
Nat. Biotechnol. 21:660-666(2003).
[10]
GLYCOSYLATION AT ASN-33; ASN-72 AND ASN-93, AND MASS SPECTROMETRY.
DOI=10.1021/pr034112b; PubMed=15253437 [NCBI, ExPASy, EBI, Israel, Japan]
Hagglund P., Bunkenborg J., Elortza F., Jensen O.N., Roepstorff P.;
"A new strategy for identification of N-glycosylated proteins and unambiguous assignment of their glycosylation sites using HILIC enrichment and partial deglycosylation.";
J. Proteome Res. 3:556-566(2004).
[11]
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-33 AND ASN-93, AND MASS SPECTROMETRY.
TISSUE=Bile;
DOI=10.1074/mcp.M400015-MCP200; PubMed=15084671 [NCBI, ExPASy, EBI, Israel, Japan]
Kristiansen T.Z., Bunkenborg J., Gronborg M., Molina H., Thuluvath P.J., Argani P., Goggins M.G., Maitra A., Pandey A.;
"A proteomic analysis of human bile.";
Mol. Cell. Proteomics 3:715-728(2004).
[12]
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-33; ASN-56; ASN-72; ASN-93 AND ASN-103, AND MASS SPECTROMETRY.
TISSUE=Plasma;
DOI=10.1002/pmic.200300556; PubMed=14760718 [NCBI, ExPASy, EBI, Israel, Japan]
Bunkenborg J., Pilch B.J., Podtelejnikov A.V., Wisniewski J.R.;
"Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.";
Proteomics 4:454-465(2004).
[13]
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-33; ASN-56; ASN-72; ASN-93 AND ASN-103, AND MASS SPECTROMETRY.
TISSUE=Plasma;
DOI=10.1021/pr0502065; PubMed=16335952 [NCBI, ExPASy, EBI, Israel, Japan]
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.;
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.";
J. Proteome Res. 4:2070-2080(2005).
[14]
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-93, AND MASS SPECTROMETRY.
TISSUE=Saliva;
DOI=10.1021/pr050492k; PubMed=16740002 [NCBI, ExPASy, EBI, Israel, Japan]
Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.;
"Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.";
J. Proteome Res. 5:1493-1503(2006).
[15]
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-93 AND ASN-103, AND MASS SPECTROMETRY.
TISSUE=Liver;
DOI=10.1021/pr8008012; PubMed=19159218 [NCBI, ExPASy, EBI, Israel, Japan]
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.";
J. Proteome Res. 8:651-661(2009).
[16]
3D-STRUCTURE MODELING.
Rojo-Dominguez A., Hernandez-Arana A.;
"Three-dimensional modeling of the protein moiety of human alpha1-acid glycoprotein, a lipocalin-family member.";
Protein Seq. Data Anal. 5:349-355(1993).
[17]
VARIANTS ARG-38 AND MET-174.
DOI=10.1007/s004390050378; PubMed=9050929 [NCBI, ExPASy, EBI, Israel, Japan]
Yuasa I., Umetsu K., Vogt U., Nakamura H., Nanba E., Tamaki N., Irizawa Y.;
"Human orosomucoid polymorphism: molecular basis of the three common ORM1 alleles, ORM1*F1, ORM1*F2, and ORM1*S.";
Hum. Genet. 99:393-398(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X02544; CAA26397.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M13692; AAA35515.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X05779; CAA29229.1; ALT_SEQ; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X05780; CAA29229.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X05781; CAA29229.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X05782; CAA29229.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X05783; CAA29229.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X05784; CAA29229.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X06676; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
X06680; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
BC026238; AAH26238.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00022429; -.
PIR A28346; OMHU1.
RefSeq NP_000598.2; -.
UniGene Hs.522356
3D structure databases
PDB
3BX6; X-ray; 1.80 A; A=19-201.[ExPASy / RCSB / EBI]
PDBsum 3BX6; -.
ModBase P02763.
Protein-protein interaction databases
IntAct P02763; 2.
PTM databases
GlycoSuiteDB P02763; -.
2D gel databases
SWISS-2DPAGE P02763; -.
Siena-2DPAGE P02763; -.
Organism-specific databases
GeneCards GC09P116125; -.
HGNC HGNC:8498; ORM1.
GenAtlas ORM1.
HPA CAB006265; -.
MIM 138600; gene. [NCBI / EBI]
PharmGKB PA260; -.
Gene expression databases
ArrayExpress P02763; -.
Bgee P02763; -.
CleanEx HS_ORM1; -.
GermOnline ENSG00000187681; Homo sapiens.
Ontologies
GO
GO:0005615; Cellular component: extracellular space (traceable author statement from ProtInc).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0006953; Biological process: acute-phase response (traceable author statement from ProtInc).
GO:0002682; Biological process: regulation of immune system process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR001500; A1A_glycop.
IPR012674; Calycin.
IPR002345; Lipocalin.
IPR000566; Lipocln_cytFABP.
Graphical view of domain structure.
Gene3D G3DSA:2.40.128.20; Calycin; 1.
PANTHER PTHR11967; A1A_glycop; 1.
Pfam PF00061; Lipocalin; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF036899; AGP; 1.
PRINTS PR00708; A1AGLPROTEIN.
PROSITE PS00213; LIPOCALIN; FALSE_NEG.
Proteomic databases
PeptideAtlas P02763; -.
PRIDE P02763; -.
Genome annotation databases
Ensembl ENSG00000187681; Homo sapiens. [Contig view]
GeneID 5004; -.
KEGG hsa:5004; -.
Phylogenomic databases
HOGENOM P02763; -.
HOVERGEN P02763; -.
Other
DrugBank DB01418; Acenocoumarol.
DB00802; Alfentanil.
DB01429; Aprindine.
DB00280; Disopyramide.
DB01359; Penbutolol.
DB00946; Phenprocoumon.
DB00908; Quinidine.
DB00706; Tamsulosin.
NextBio 19272; -.
SOURCE ORM1; Homo sapiens.
ProtoNet P02763.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Acute phase; Direct protein sequencing; Disulfide bond; Glycoprotein; Polymorphism; Pyrrolidone carboxylic acid; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
SIGNAL   1    18  18      
CHAIN   19   201  183     Alpha-1-acid glycoprotein 1. PRO_0000017860
MOD_RES   19    19        Pyrrolidone carboxylic acid. 
CARBOHYD   33    33        N-linked (GlcNAc...). 
CARBOHYD   56    56        N-linked (GlcNAc...). 
CARBOHYD   72    72        N-linked (GlcNAc...). 
CARBOHYD   93    93        N-linked (GlcNAc...). 
CARBOHYD   103   103        N-linked (GlcNAc...) [GlycoSuiteDB]. CAR_000170
DISULFID   23   165         
DISULFID   90   183         
VARIANT   38    38  1     Q -> R (in allele ORM1*S). VAR_013840 
VARIANT   167   167  1     R -> C (in dbSNP:rs3182034 [NCBI]). VAR_056166 
VARIANT   174   174  1     V -> M (in allele ORM1*F2; dbSNP:rs1126801 [NCBI]). VAR_013841 
CONFLICT   182   182        Missing (in Ref. 6; AA sequence). 
CONFLICT   193   193        Missing (in Ref. 6; AA sequence). 
Sequence information
Length: 201 AA [This is the length of the unprocessed precursor] Molecular weight: 23512 Da [This is the MW of the unprocessed precursor] CRC64: 63292233AD6EAD8B [This is a checksum on the sequence]
        10         20         30         40         50         60 
MALSWVLTVL SLLPLLEAQI PLCANLVPVP ITNATLDQIT GKWFYIASAF RNEEYNKSVQ 

        70         80         90        100        110        120 
EIQATFFYFT PNKTEDTIFL REYQTRQDQC IYNTTYLNVQ RENGTISRYV GGQEHFAHLL 

       130        140        150        160        170        180 
ILRDTKTYML AFDVNDEKNW GLSVYADKPE TTKEQLGEFY EALDCLRIPK SDVVYTDWKK 

       190        200 
DKCEPLEKQH EKERKQEEGE S 

P02763 in FASTA format

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