[1]
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NUCLEOTIDE SEQUENCE (ISOFORM 1).
DOI=10.1021/bi00163a002; PubMed=1457396 [NCBI, ExPASy, EBI, Israel, Japan]
Fu Y.,
Weissbach L.,
Plant P.W.,
Oddoux C.,
Cao Y.,
Liang T.J.,
Roy S.N.,
Redman C.M.,
Grieninger G.;
"Carboxy-terminal-extended variant of the human fibrinogen alpha subunit: a novel exon conferring marked homology to beta and gamma subunits.";
Biochemistry 31:11968-11972(1992).
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[2]
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NUCLEOTIDE SEQUENCE (ISOFORM 1).
Chung D.W.,
Grieninger G.;
"Fibrinogen DNA and protein sequences.";
(In) Ebert R.F. (eds.); Index of variant human fibrinogens, pp.13-24, CRC Press, Boca Raton (1994).
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[3]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS VAL-6; ALA-331 AND ALA-456.
SeattleSNPs program for genomic applications;
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
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[4]
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NUCLEOTIDE SEQUENCE OF 1-655 (ISOFORM 1).
TISSUE=Liver;
PubMed=2102623 [NCBI, ExPASy, EBI, Israel, Japan]
Chung D.W.,
Harris J.E.,
Davie E.W.;
"Nucleotide sequences of the three genes coding for human fibrinogen.";
Adv. Exp. Med. Biol. 281:39-48(1990).
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[5]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
PubMed=6575389 [NCBI, ExPASy, EBI, Israel, Japan]
Kant J.A.,
Lord S.T.,
Crabtree G.R.;
"Partial mRNA sequences for human A alpha, B beta, and gamma fibrinogen chains: evolutionary and functional implications.";
Proc. Natl. Acad. Sci. U.S.A. 80:3953-3957(1983).
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[6]
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NUCLEOTIDE SEQUENCE [MRNA] OF 1-629.
DOI=10.1021/bi00282a031; PubMed=6688355 [NCBI, ExPASy, EBI, Israel, Japan]
Rixon M.W.,
Chan W.-Y.,
Davie E.W.,
Chung D.W.;
"Characterization of a complementary deoxyribonucleic acid coding for the alpha chain of human fibrinogen.";
Biochemistry 22:3237-3244(1983).
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[7]
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PROTEIN SEQUENCE OF 20-629.
Henschen A.,
Lottspeich F.,
Southan C.,
Topfer-Petersen E.;
"Human fibrinogen: sequence, sulfur bridges, glycosylation and some structural variants.";
(In) Peeters H. (eds.); Protides of the biological fluids, Proc. 28th colloquium, pp.51-56, Pergamon Press, Oxford (1980).
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[8]
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PROTEIN SEQUENCE OF 20-629, AND DISULFIDE BONDS.
DOI=10.1021/bi00591a024; PubMed=518846 [NCBI, ExPASy, EBI, Israel, Japan]
Watt K.W.K.,
Cottrell B.A.,
Strong D.D.,
Doolittle R.F.;
"Amino acid sequence studies on the alpha chain of human fibrinogen. Overlapping sequences providing the complete sequence.";
Biochemistry 18:5410-5416(1979).
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[9]
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NUCLEOTIDE SEQUENCE [MRNA] OF 110-156.
DOI=10.1093/nar/11.21.7427; PubMed=6689067 [NCBI, ExPASy, EBI, Israel, Japan]
Imam A.M.A.,
Eaton M.A.W.,
Williamson R.,
Humphries S.;
"Isolation and characterisation of cDNA clones for the A alpha- and gamma-chains of human fibrinogen.";
Nucleic Acids Res. 11:7427-7434(1983).
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[10]
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NUCLEOTIDE SEQUENCE OF 605-644 (ISOFORM 2).
PubMed=6575700 [NCBI, ExPASy, EBI, Israel, Japan]
Chung D.W.,
Rixon M.W.,
Que B.G.,
Davie E.W.;
"Cloning of fibrinogen genes and their cDNA.";
Ann. N. Y. Acad. Sci. 408:449-456(1983).
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[11]
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PROTEIN SEQUENCE OF 20-35.
Blombaeck B.,
Blombaeck M.,
Grondahl N.J.,
Guthrie C.,
Hinton M.;
"Studies on fibrinopeptides from primates.";
Acta Chem. Scand. 19:1788-1789(1965).
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[12]
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CROSS-LINKING ACCEPTOR SITES.
DOI=10.1021/bi00591a023; PubMed=518845 [NCBI, ExPASy, EBI, Israel, Japan]
Cottrell B.A.,
Strong D.D.,
Watt K.W.K.,
Doolittle R.F.;
"Amino acid sequence studies on the alpha chain of human fibrinogen. Exact location of cross-linking acceptor sites.";
Biochemistry 18:5405-5410(1979).
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[13]
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CROSS-LINKING ACCEPTOR SITES.
PubMed=632262 [NCBI, ExPASy, EBI, Israel, Japan]
Fretto L.J.,
Ferguson E.W.,
Steinman H.M.,
McKee P.A.;
"Localization of the alpha-chain cross-link acceptor sites of human fibrin.";
J. Biol. Chem. 253:2184-2195(1978).
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[14]
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GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-686, AND MASS SPECTROMETRY.
TISSUE=Plasma;
DOI=10.1021/pr0502065; PubMed=16335952 [NCBI, ExPASy, EBI, Israel, Japan]
Liu T.,
Qian W.-J.,
Gritsenko M.A.,
Camp D.G. II,
Monroe M.E.,
Moore R.J.,
Smith R.D.;
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.";
J. Proteome Res. 4:2070-2080(2005).
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[15]
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DISULFIDE BONDS.
DOI=10.1016/0049-3848(76)90245-0; PubMed=936108 [NCBI, ExPASy, EBI, Israel, Japan]
Blombaeck B.,
Hessel B.,
Hogg D.;
"Disulfide bridges in NH2-terminal part of human fibrinogen.";
Thromb. Res. 8:639-658(1976).
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[16]
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REVIEW, ELECTRON MICROSCOPY, POLYMERIZATION, AND LIGANDS.
PubMed=6383194 [NCBI, ExPASy, EBI, Israel, Japan]
Doolittle R.F.;
"Fibrinogen and fibrin.";
Annu. Rev. Biochem. 53:195-229(1984).
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[17]
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CROSS-LINKING SITE FOR ALPHA-2-PLASMIN INHIBITOR.
PubMed=2877981 [NCBI, ExPASy, EBI, Israel, Japan]
Kimura S.,
Aoki N.;
"Cross-linking site in fibrinogen for alpha 2-plasmin inhibitor.";
J. Biol. Chem. 261:15591-15595(1986).
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[18]
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PHOSPHORYLATION.
DOI=10.1016/0006-291X(83)91247-0; PubMed=6318767 [NCBI, ExPASy, EBI, Israel, Japan]
Itarte E.,
Plana M.,
Guasch M.D.,
Martos C.;
"Phosphorylation of fibrinogen by casein kinase 1.";
Biochem. Biophys. Res. Commun. 117:631-636(1983).
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[19]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22, AND MASS SPECTROMETRY.
TISSUE=Pituitary;
DOI=10.1007/s11102-006-8916-x; PubMed=16807684 [NCBI, ExPASy, EBI, Israel, Japan]
Beranova-Giorgianni S.,
Zhao Y.,
Desiderio D.M.,
Giorgianni F.;
"Phosphoproteomic analysis of the human pituitary.";
Pituitary 9:109-120(2006).
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[20]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-277, AND MASS SPECTROMETRY.
DOI=10.1016/j.cell.2007.11.025; PubMed=18083107 [NCBI, ExPASy, EBI, Israel, Japan]
Rikova K.,
Guo A.,
Zeng Q.,
Possemato A.,
Yu J.,
Haack H.,
Nardone J.,
Lee K.,
Reeves C.,
Li Y.,
Hu Y.,
Tan Z.,
Stokes M.,
Sullivan L.,
Mitchell J.,
Wetzel R.,
Macneill J.,
Ren J.M.,
Yuan J., ![]()
Bakalarski C.E.,
Villen J.,
Kornhauser J.M.,
Smith B.,
Li D.,
Zhou X.,
Gygi S.P.,
Gu T.-L.,
Polakiewicz R.D.,
Rush J.,
Comb M.J.;
"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.";
Cell 131:1190-1203(2007).
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[21]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-364; THR-412; SER-524; SER-549 AND SER-609, AND MASS SPECTROMETRY.
TISSUE=Platelet;
DOI=10.1021/pr0704130; PubMed=18088087 [NCBI, ExPASy, EBI, Israel, Japan]
Zahedi R.P.,
Lewandrowski U.,
Wiesner J.,
Wortelkamp S.,
Moebius J.,
Schuetz C.,
Walter U.,
Gambaryan S.,
Sickmann A.;
"Phosphoproteome of resting human platelets.";
J. Proteome Res. 7:526-534(2008).
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[22]
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X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 26-39.
PubMed=1560020 [NCBI, ExPASy, EBI, Israel, Japan]
Martin P.D.,
Robertson W.,
Turk D.,
Huber R.,
Bode W.,
Edwards B.F.P.;
"The structure of residues 7-16 of the A alpha-chain of human fibrinogen bound to bovine thrombin at 2.3-A resolution.";
J. Biol. Chem. 267:7911-7920(1992).
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[23]
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X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 130-216.
DOI=10.1038/38947; PubMed=9333233 [NCBI, ExPASy, EBI, Israel, Japan]
Spraggon G.,
Everse S.J.,
Doolittle R.F.;
"Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin.";
Nature 389:455-462(1997).
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[24]
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X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 130-216.
DOI=10.1021/bi9804129; PubMed=9628725 [NCBI, ExPASy, EBI, Israel, Japan]
Everse S.J.,
Spraggon G.,
Veerapandian L.,
Riley M.,
Doolittle R.F.;
"Crystal structure of fragment double-D from human fibrin with two different bound ligands.";
Biochemistry 37:8637-8642(1998).
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[25]
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X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 670-866.
DOI=10.1073/pnas.95.16.9099; PubMed=9689040 [NCBI, ExPASy, EBI, Israel, Japan]
Spraggon G.,
Applegate D.,
Everse S.J.,
Zhang J.Z.,
Veerapandian L.,
Redman C.,
Doolittle R.F.,
Grieninger G.;
"Crystal structure of a recombinant alphaEC domain from human fibrinogen-420.";
Proc. Natl. Acad. Sci. U.S.A. 95:9099-9104(1998).
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[26]
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X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 130-216.
DOI=10.1021/bi982626w; PubMed=10074346 [NCBI, ExPASy, EBI, Israel, Japan]
Everse S.J.,
Spraggon G.,
Veerapandian L.,
Doolittle R.F.;
"Conformational changes in fragments D and double-D from human fibrin(ogen) upon binding the peptide ligand Gly-His-Arg-Pro-amide.";
Biochemistry 38:2941-2946(1999).
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[27]
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VARIANT KYOTO-2.
PubMed=2070049 [NCBI, ExPASy, EBI, Israel, Japan]
Yoshida N.,
Okuma M.,
Hirata H.,
Matsuda M.,
Yamazumi K.,
Asakura S.;
"Fibrinogen Kyoto II, a new congenitally abnormal molecule, characterized by the replacement of A alpha proline-18 by leucine.";
Blood 78:149-153(1991).
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[28]
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VARIANT LIMA.
PubMed=1634621 [NCBI, ExPASy, EBI, Israel, Japan]
Maekawa H.,
Yamazumi K.,
Muramatsu S.,
Kaneko M.,
Hirata H.,
Takahashi N.,
Arocha-Pinango C.L.,
Rodriguez S.,
Nagy H.,
Perez-Requejo J.L.,
Matsuda M.;
"Fibrinogen Lima: a homozygous dysfibrinogen with an A alpha-arginine-141 to serine substitution associated with extra N-glycosylation at A alpha-asparagine-139. Impaired fibrin gel formation but normal fibrin-facilitated plasminogen activation catalyzed by tissue-type plasminogen activator.";
J. Clin. Invest. 90:67-76(1992).
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[29]
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VARIANT CARACAS-2.
PubMed=1675636 [NCBI, ExPASy, EBI, Israel, Japan]
Maekawa H.,
Yamazumi K.,
Muramatsu S.,
Kaneko M.,
Hirata H.,
Takahashi N.,
de Bosch N.B.,
Carvajal Z.,
Ojeda A.,
Arocha-Pinango C.L.,
Matsuda M.;
"An A alpha Ser-434 to N-glycosylated Asn substitution in a dysfibrinogen, fibrinogen Caracas II, characterized by impaired fibrin gel formation.";
J. Biol. Chem. 266:11575-11581(1991).
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[30]
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VARIANT DUSART.
PubMed=8473507 [NCBI, ExPASy, EBI, Israel, Japan]
Koopman J.,
Haverkate F.,
Grimbergen J.,
Lord S.T.,
Mosesson M.W.,
Diorio J.P.,
Siebenlist K.S.,
Legrand C.,
Soria J.,
Soria C.,
Caen J.P.;
"Molecular basis for fibrinogen Dusart (A alpha 554 Arg-->Cys) and its association with abnormal fibrin polymerization and thrombophilia.";
J. Clin. Invest. 91:1637-1643(1993).
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[31]
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VARIANT RENAL AMYLOIDOSIS LEU-573.
DOI=10.1038/ng0393-252; PubMed=8097946 [NCBI, ExPASy, EBI, Israel, Japan]
Benson M.D.,
Liepnieks J.,
Uemichi T.,
Wheeler G.,
Correa R.;
"Hereditary renal amyloidosis associated with a mutant fibrinogen alpha-chain.";
Nat. Genet. 3:252-255(1993).
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[32]
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VARIANT OSAKA IV HIS-35.
DOI=10.1007/BF00308999; PubMed=8461606 [NCBI, ExPASy, EBI, Israel, Japan]
Yamazumi K.,
Terukina S.,
Matsuda M.,
Kanbayashi J.,
Sakon M.,
Tsujinaka T.;
"Fibrinogen Osaka IV: a congenital dysfibrinogenemia found in a patient originally reported in relation to surgery, now defined to have an A alpha arginine-16 to histidine substitution.";
Surg. Today 23:45-50(1993).
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[33]
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VARIANT CANTERBURY.
PubMed=8675656 [NCBI, ExPASy, EBI, Israel, Japan]
Brennan S.O.,
Hammonds B.,
George P.M.;
"Aberrant hepatic processing causes removal of activation peptide and primary polymerisation site from fibrinogen Canterbury (A-alpha 20 Val-to-Asp).";
J. Clin. Invest. 96:2854-2858(1995).
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[34]
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VARIANTS ALA-331 AND GLU-446.
DOI=10.1038/10290; PubMed=10391209 [NCBI, ExPASy, EBI, Israel, Japan]
Cargill M.,
Altshuler D.,
Ireland J.,
Sklar P.,
Ardlie K.,
Patil N.,
Shaw N.,
Lane C.R.,
Lim E.P.,
Kalyanaraman N.,
Nemesh J.,
Ziaugra L.,
Friedland L.,
Rolfe A.,
Warrington J.,
Lipshutz R.,
Daley G.Q.,
Lander E.S.;
"Characterization of single-nucleotide polymorphisms in coding regions of human genes.";
Nat. Genet. 22:231-238(1999).
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[35]
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ERRATUM.
Cargill M.,
Altshuler D.,
Ireland J.,
Sklar P.,
Ardlie K.,
Patil N.,
Shaw N.,
Lane C.R.,
Lim E.P.,
Kalyanaraman N.,
Nemesh J.,
Ziaugra L.,
Friedland L.,
Rolfe A.,
Warrington J.,
Lipshutz R.,
Daley G.Q.,
Lander E.S.;
Nat. Genet. 23:373-373(1999).
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