ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry P02668


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name CASK_BOVIN
Primary accession number P02668
Secondary accession numbers O46566 Q597F3 Q6U205 Q9N271 Q9TRQ3 Q9TV96 Q9TV97
Integrated into Swiss-Prot on July 21, 1986
Sequence was last modified on April 1, 1988 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 87)
Name and origin of the protein
Protein name Kappa-casein [Precursor]
Synonyms None
Contains Casoxin-C
Casoxin-6
Casoxin-A
Casoxin-B
Casoplatelin
Gene name
Name: CSN3
Synonyms: CSN10, CSNK
From
Bos taurus (Bovine) [TaxID: 9913] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (VARIANT A).
DOI=10.1093/nar/12.9.3895; PubMed=6328443 [NCBI, ExPASy, EBI, Israel, Japan]
Stewart A.F., Willis I.M., Mackinlay A.G.;
"Nucleotide sequences of bovine alpha S1- and kappa-casein cDNAs.";
Nucleic Acids Res. 12:3895-3907(1984).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (VARIANT B2).
PubMed=3582972 [NCBI, ExPASy, EBI, Israel, Japan]
Gorodetskii S.I., Kaledin A.S.;
"Nucleotide sequence of the cDNA of kappa casein in cows.";
Genetika 23:596-604(1987).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (VARIANT A).
PubMed=3208764 [NCBI, ExPASy, EBI, Israel, Japan]
Alexander L.J., Stewart A.F., McKinlay A.G., Kapelinskaya T.V., Tkach T.M., Gorodetsky S.I.;
"Isolation and characterization of the bovine kappa-casein gene.";
Eur. J. Biochem. 178:395-401(1988).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (VARIANTS A AND B).
TISSUE=Blood;
DOI=10.1111/j.1365-2052.2005.01260.x; PubMed=15771744 [NCBI, ExPASy, EBI, Israel, Japan]
Robitaille G., Britten M., Morisset J., Petitclerc D.;
"Polymorphism in the bovine kappa-casein (CSN3) gene and the 5'-flanking region: sequence analysis of CSN3 A and B alleles.";
Anim. Genet. 36:184-185(2005).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (VARIANT B).
STRAIN=Hereford;
TISSUE=Mammary gland;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
[6]
PROTEIN SEQUENCE OF 22-127 (VARIANT B).
PubMed=4577852 [NCBI, ExPASy, EBI, Israel, Japan]
Mercier J.-C., Brignon G., Ribadeau-Dumas B.;
"Primary structure of bovine kappa B casein. Complete sequence.";
Eur. J. Biochem. 35:222-235(1973).
[7]
PROTEIN SEQUENCE OF 22-126 (VARIANT A).
Jolles J., Schoentgen F., Alais C., Jolles P.;
"Studies on the primary structure of cow kappa-casein. The primary sequence of cow para-kappa-casein.";
Chimia 26:645-646(1972).
[8]
PROTEIN SEQUENCE OF 22-38 AND 97-116, INTERCHAIN DISULFIDE BONDS, AND MASS SPECTROMETRY.
PubMed=1628650 [NCBI, ExPASy, EBI, Israel, Japan]
Rasmussen L.K., Hoejrup P., Petersen T.E.;
"The multimeric structure and disulfide-bonding pattern of bovine kappa-casein.";
Eur. J. Biochem. 207:215-222(1992).
[9]
NUCLEOTIDE SEQUENCE [MRNA] OF 31-45.
PubMed=6897774 [NCBI, ExPASy, EBI, Israel, Japan]
Willis I.M., Stewart A.F., Caputo A., Thompson A.R., McKinlay A.G.;
"Construction and identification by partial nucleotide sequence analysis of bovine casein and beta-lactoglobulin cDNA clones.";
DNA 1:375-386(1982).
[10]
NUCLEOTIDE SEQUENCE OF 31-190 (VARIANTS F AND G).
STRAIN=Ayrshire, and Pinzgauer;
PubMed=8930077 [NCBI, ExPASy, EBI, Israel, Japan]
Prinzenberg E.M., Hiendleder S., Ikonen T., Erhardt G.;
"Molecular genetic characterization of new bovine kappa-casein alleles CSN3F and CSN3G and genotyping by PCR-RFLP.";
Anim. Genet. 27:347-349(1996).
[11]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 31-190 (VARIANT H).
STRAIN=Pinzgauer;
PubMed=10654430 [NCBI, ExPASy, EBI, Israel, Japan]
Prinzenberg E.M., Krause I., Erhardt G.;
"SSCP analysis at the bovine CSN3 locus discriminates six alleles corresponding to known protein variants (A, B, C, E, F, G) and three new DNA polymorphisms (H, I, A1).";
Anim. Biotechnol. 10:49-62(1999).
[12]
PROTEIN SEQUENCE OF 54-59.
PubMed=8161175 [NCBI, ExPASy, EBI, Israel, Japan]
Reid J.R., Coolbear T., Pillidge C.J., Pritchard G.G.;
"Specificity of hydrolysis of bovine kappa-casein by cell envelope-associated proteinases from Lactococcus lactis strains.";
Appl. Environ. Microbiol. 60:801-806(1994).
[13]
NUCLEOTIDE SEQUENCE [MRNA] OF 92-190 (VARIANT B2).
PubMed=6689612 [NCBI, ExPASy, EBI, Israel, Japan]
Gorodetskii S.I., Kershulyte D.R., Korobko V.G.;
"Primary structure of cDNA of Bos taurus kappa-casein macropeptide.";
Bioorg. Khim. 9:1693-1695(1983).
[14]
PARTIAL PROTEIN SEQUENCE (VARIANT A).
DOI=10.1002/hlca.19720550820; PubMed=4653404 [NCBI, ExPASy, EBI, Israel, Japan]
Jolles J., Schoentgen F., Alais C., Fiat A.-M., Jolles P.;
"Studies on the primary structure of cow kappa-casein. Structural features of para-kappa-casein; N-terminal sequence of kappa-caseinoglycopeptide studied with a sequencer.";
Helv. Chim. Acta 55:2872-2883(1972).
[15]
PROTEIN SEQUENCE OF 127-168 AND 187-190.
TISSUE=Colostrum;
PubMed=4407313 [NCBI, ExPASy, EBI, Israel, Japan]
Guerin J., Alais C., Jolles J., Jolles P.;
"Kappa-casein from bovine colostrum.";
Biochim. Biophys. Acta 351:325-332(1974).
[16]
PROTEIN SEQUENCE OF 128-190 (VARIANTS A AND B).
Grosclaude F., Mahe M.-F., Mercier J.-C., Ribadeau-Dumas B.;
"Localization of amino-acid substitutions that differenciate bovine kappa-casein variants A and B.";
Ann. Genet. Sel. Anim. 4:515-521(1972).
[17]
NUCLEOTIDE SEQUENCE OF 133-190 (VARIANT E).
PubMed=1683188 [NCBI, ExPASy, EBI, Israel, Japan]
Schlieben S., Erhardt G., Senft B.;
"Genotyping of bovine kappa-casein (kappa-CNA, kappa-CNB, kappa-CNC, kappa-CNE) following DNA sequence amplification and direct sequencing of kappa-CNE PCR product.";
Anim. Genet. 22:333-342(1991).
[18]
NUCLEOTIDE SEQUENCE OF 133-190 (VARIANTS A AND B).
Woollard J.R., Dentine M.R.;
Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.
[19]
GLYCOSYLATION AT THR-142; THR-152; THR-154; THR-157; THR-163 AND THR-186.
DOI=10.1093/glycob/4.6.837; PubMed=7734846 [NCBI, ExPASy, EBI, Israel, Japan]
Pisano A., Packer N.H., Redmond J.W., Williams K.L., Gooley A.A.;
"Characterization of O-linked glycosylation motifs in the glycopeptide domain of bovine kappa-casein.";
Glycobiology 4:837-844(1994).
[20]
GLYCOSYLATION AT THR-142; THR-152; THR-154; THR-157; THR-163 AND THR-186, AND PHOSPHORYLATION AT SER-148 AND SER-170.
DOI=10.1016/0021-9673(96)00122-7; PubMed=8817876 [NCBI, ExPASy, EBI, Israel, Japan]
Minkiewicz P., Slangen C.J., Lagerwerf F.M., Haverkamp J., Rollema H.S., Visser S.;
"Reversed-phase high-performance liquid chromatographic separation of bovine kappa-casein macropeptide and characterization of isolated fractions.";
J. Chromatogr. A 743:123-135(1996).
[21]
ACTIVITY OF CASOXINS.
PubMed=2760302 [NCBI, ExPASy, EBI, Israel, Japan]
Chiba H., Tani F., Yoshikawa M.;
"Opioid antagonist peptides derived from kappa-casein.";
J. Dairy Res. 56:363-366(1989).
[22]
ACTIVITY OF CASOPLATELIN.
PubMed=3732274 [NCBI, ExPASy, EBI, Israel, Japan]
Jolles P., Levy-Toledano S., Fiat A.-M., Soria C., Gillessen D., Thomaidis A., Dunn F.W., Caen J.P.;
"Analogy between fibrinogen and casein. Effect of an undecapeptide isolated from kappa-casein on platelet function.";
Eur. J. Biochem. 158:379-382(1986).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X00565; CAA25231.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M36641; AAA30433.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X14907; CAA33034.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X14908; CAA33034.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY380228; AAQ87922.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY380229; AAQ87923.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC102120; AAI02121.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
K01085; AAA30482.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF123250; AAD32139.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF123251; AAD32140.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF105260; AAF72097.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M38333; AAA30432.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF041482; AAB97519.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U84250; AAB47260.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U84251; AAB47261.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S02076; KKBOB.
RefSeq NP_776719.1; -.
UniGene Bt.49421
3D structure databases
DisProt DP00192; -.
ModBase P02668.
PTM databases
GlycoSuiteDB P02668; -.
Family and domain databases
InterPro IPR000117; Casein_kappa.
Graphical view of domain structure.
PANTHER PTHR11470; Casein_kappa; 1.
Pfam PF00997; Casein_kappa; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF002374; Casein_kappa; 1.
ProDom PD003689; Casein_kappa; 1.
[Domain structure / List of seq. sharing at least 1 domain]
BLOCKS P02668.
ProtoNet P02668.
Genome annotation databases
Ensembl ENSBTAG00000039787; Bos taurus. [Contig view]
GeneID 281728; -.
KEGG bta:281728; -.
Phylogenomic databases
HOVERGEN P02668; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Direct protein sequencing; Glycoprotein; Milk protein; Phosphoprotein; Pyrrolidone carboxylic acid; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    21  21      
CHAIN   22   190  169     Kappa-casein. PRO_0000004483
PEPTIDE   46    55  10     Casoxin-C. PRO_0000004484
PEPTIDE   54    59  6     Casoxin-6. PRO_0000004485
PEPTIDE   56    62  7     Casoxin-A. PRO_0000004486
PEPTIDE   79    82  4     Casoxin-B. PRO_0000004487
PEPTIDE   127   137  11     Casoplatelin. PRO_0000004488
SITE   126   127  2     Cleavage; by chymosin/rennin. 
MOD_RES   22    22        Pyrrolidone carboxylic acid. 
MOD_RES   148   148        Phosphoserine. 
MOD_RES   170   170        Phosphoserine. 
CARBOHYD   142   142        O-linked (GalNAc...). 
CARBOHYD   152   152        O-linked (GalNAc...). 
CARBOHYD   154   154        O-linked (GalNAc...). 
CARBOHYD   157   157        O-linked (GalNAc...). 
CARBOHYD   163   163        O-linked (GalNAc...). 
CARBOHYD   186   186        O-linked (GalNAc...); partial. 
DISULFID   32   109        Alternate. 
DISULFID   32    32        Interchain (with C-109); alternate. 
DISULFID   32    32        Interchain; alternate. 
DISULFID   109   109        Interchain (with C-32); alternate. 
DISULFID   109   109        Interchain; alternate. 
VARIANT   31    31  1     R -> H (in variant F). 
VARIANT   118   118  1     R -> C (in variant G). 
VARIANT   156   156  1     T -> I (in variant G and variant H). 
VARIANT   157   157  1     T -> I (in variant B and variant B2). 
VARIANT   169   169  1     D -> A (in variant B and variant B2). 
VARIANT   174   174  1     I -> T (in variant B2). 
VARIANT   176   176  1     S -> G (in variant E). 
CONFLICT   23    23        E -> Q (in Ref. 7; AA sequence). 
CONFLICT   26    26        Q -> E (in Ref. 7; AA sequence). 
CONFLICT   28    28        Q -> E (in Ref. 7; AA sequence). 
CONFLICT   102   102        N -> D (in Ref. 6; AA sequence). 
Sequence information
Length: 190 AA [This is the length of the unprocessed precursor] Molecular weight: 21269 Da [This is the MW of the unprocessed precursor] CRC64: F12D8310C3B93EDA [This is a checksum on the sequence]
        10         20         30         40         50         60 
MMKSFFLVVT ILALTLPFLG AQEQNQEQPI RCEKDERFFS DKIAKYIPIQ YVLSRYPSYG 

        70         80         90        100        110        120 
LNYYQQKPVA LINNQFLPYP YYAKPAAVRS PAQILQWQVL SNTVPAKSCQ AQPTTMARHP 

       130        140        150        160        170        180 
HPHLSFMAIP PKKNQDKTEI PTINTIASGE PTSTPTTEAV ESTVATLEDS PEVIESPPEI 

       190 
NTVQVTSTAV 

P02668 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by ch flag SIB Switzerland Mirror sites: Australia  Brazil  Canada  China  Korea
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!